Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves

This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control...

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Main Authors: Khin, Myat Nwe, Saad, Mohd Zamri, Mohamed Mustapha, Noordin, Abd Wahid, Mohd Effendy
Format: Article
Language:English
Published: Online Journal of Veterinary Research 2009
Online Access:http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf
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author Khin, Myat Nwe
Saad, Mohd Zamri
Mohamed Mustapha, Noordin
Abd Wahid, Mohd Effendy
author_facet Khin, Myat Nwe
Saad, Mohd Zamri
Mohamed Mustapha, Noordin
Abd Wahid, Mohd Effendy
author_sort Khin, Myat Nwe
collection UPM
description This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control untreated calves were kept separate. After 6 weeks, all calves were challenged intra-tracheally with 107 CFU/mL of live wild-type P. multocida B:2. At Post-Mortem none of the vaccinated or mingled calves had lesions whereas controls revealed pulmonary petechial haemorrhages with acute pneumonia patches with neutrophils. Both exposed and commingled calves showed significantly (p<0.05) higher levels of serum IgG. P. multocida B:2 were successfully isolated only from the control calves of Group 3. These findings suggest that intranasal exposures to live attenuated P. multocida B:2 prevented infection by wild-type P. multocida B:2 and may have protected susceptible calves.
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spelling upm.eprints-70642016-11-22T01:09:45Z http://psasir.upm.edu.my/id/eprint/7064/ Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control untreated calves were kept separate. After 6 weeks, all calves were challenged intra-tracheally with 107 CFU/mL of live wild-type P. multocida B:2. At Post-Mortem none of the vaccinated or mingled calves had lesions whereas controls revealed pulmonary petechial haemorrhages with acute pneumonia patches with neutrophils. Both exposed and commingled calves showed significantly (p<0.05) higher levels of serum IgG. P. multocida B:2 were successfully isolated only from the control calves of Group 3. These findings suggest that intranasal exposures to live attenuated P. multocida B:2 prevented infection by wild-type P. multocida B:2 and may have protected susceptible calves. Online Journal of Veterinary Research 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf Khin, Myat Nwe and Saad, Mohd Zamri and Mohamed Mustapha, Noordin and Abd Wahid, Mohd Effendy (2009) Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves. Online Journal of Veterinary Research, 13 (2). pp. 65-72. ISSN 1328-925X http://onljvetres.com/pasteurellaabs2009.htm
spellingShingle Khin, Myat Nwe
Saad, Mohd Zamri
Mohamed Mustapha, Noordin
Abd Wahid, Mohd Effendy
Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
title Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
title_full Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
title_fullStr Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
title_full_unstemmed Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
title_short Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
title_sort effect of intranasal attenuated pasteurella multocida b 2 on haemorrhagic septicaemia in calves
url http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf
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