Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control...
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Format: | Article |
Language: | English |
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Online Journal of Veterinary Research
2009
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Online Access: | http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf |
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author | Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy |
author_facet | Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy |
author_sort | Khin, Myat Nwe |
collection | UPM |
description | This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control untreated calves were kept separate. After 6 weeks, all calves were challenged intra-tracheally with 107 CFU/mL of live wild-type P. multocida B:2. At Post-Mortem none of the vaccinated or mingled calves had lesions whereas controls revealed pulmonary petechial haemorrhages with acute pneumonia patches with neutrophils. Both exposed and commingled calves showed significantly (p<0.05) higher levels of serum IgG. P. multocida B:2 were successfully isolated only from the control calves of Group 3. These findings suggest that intranasal exposures to live attenuated P. multocida B:2 prevented infection by wild-type P. multocida B:2 and may have protected susceptible calves. |
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format | Article |
id | upm.eprints-7064 |
institution | Universiti Putra Malaysia |
language | English |
last_indexed | 2024-03-06T07:11:08Z |
publishDate | 2009 |
publisher | Online Journal of Veterinary Research |
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spelling | upm.eprints-70642016-11-22T01:09:45Z http://psasir.upm.edu.my/id/eprint/7064/ Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control untreated calves were kept separate. After 6 weeks, all calves were challenged intra-tracheally with 107 CFU/mL of live wild-type P. multocida B:2. At Post-Mortem none of the vaccinated or mingled calves had lesions whereas controls revealed pulmonary petechial haemorrhages with acute pneumonia patches with neutrophils. Both exposed and commingled calves showed significantly (p<0.05) higher levels of serum IgG. P. multocida B:2 were successfully isolated only from the control calves of Group 3. These findings suggest that intranasal exposures to live attenuated P. multocida B:2 prevented infection by wild-type P. multocida B:2 and may have protected susceptible calves. Online Journal of Veterinary Research 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf Khin, Myat Nwe and Saad, Mohd Zamri and Mohamed Mustapha, Noordin and Abd Wahid, Mohd Effendy (2009) Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves. Online Journal of Veterinary Research, 13 (2). pp. 65-72. ISSN 1328-925X http://onljvetres.com/pasteurellaabs2009.htm |
spellingShingle | Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
title | Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
title_full | Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
title_fullStr | Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
title_full_unstemmed | Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
title_short | Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
title_sort | effect of intranasal attenuated pasteurella multocida b 2 on haemorrhagic septicaemia in calves |
url | http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf |
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