Development, characterisation and translocation of valproic acid-encapsulated nanoemulsion across blood-brain barrier
Valproic acid (VPA) is a widely used antiepileptic drug (AED) for epilepsy especially in generalized and absence seizures. However, VPA has high plasma protein binding (90 % - 95 %) so only low amount of free VPA were able to reach the brain. An increase in therapeutic dose is not feasible as it wil...
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| Format: | Thesis |
| Language: | English |
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2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/70689/1/FPSK%28P%29%202017%2013%20-%20IR.pdf |