Cytomegalovirus replication steps and the actions of antiviral drugs
Human cytomegalovirus (HCMV) is a beta herpesvirus that inflicts an active infection in the fetus and immunosuppressive patients. The virus encodes many proteins that work together with cellular factors to achieve virus replication. In addition to vaccines, antiviral drugs can be deployed to manipul...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Bentham Science Publishers
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72163/1/Cytomegalovirus%20replication%20steps%20and%20the%20actions%20of%20antiviral%20drugs.pdf |
| _version_ | 1825950040540053504 |
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| author | Abdullah, Ashwaq Ahmed Balakrishnan, Krishnan Nair Bala, Jamilu Abubakar Abdullah, Faez Firdaus Jesse Allaudin, Zeenatul Nazariah Abdullah, Rasedee Noordin, Mohamed Mustapha Mohd Lila, Mohd Azmi |
| author_facet | Abdullah, Ashwaq Ahmed Balakrishnan, Krishnan Nair Bala, Jamilu Abubakar Abdullah, Faez Firdaus Jesse Allaudin, Zeenatul Nazariah Abdullah, Rasedee Noordin, Mohamed Mustapha Mohd Lila, Mohd Azmi |
| author_sort | Abdullah, Ashwaq Ahmed |
| collection | UPM |
| description | Human cytomegalovirus (HCMV) is a beta herpesvirus that inflicts an active infection in the fetus and immunosuppressive patients. The virus encodes many proteins that work together with cellular factors to achieve virus replication. In addition to vaccines, antiviral drugs can be deployed to manipulate how the virus replicates and minimize its pathogenicity. The five antiviral drugs approved by the Food and Drug Administration (FDA) have shown adverse reactions and the antiviral drug resistance were reported. Hence, this warrants the need for urgent development of a novel antiviral drug. Detailed understanding of the virus replication steps and how cellular signals interact with these steps will be key for pharmacological developments of for anti HCMV drugs. This review summarized all the drugs that target the virus proteins and cell signals that mediate CMV replication. |
| first_indexed | 2024-03-06T10:08:32Z |
| format | Article |
| id | upm.eprints-72163 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:08:32Z |
| publishDate | 2018 |
| publisher | Bentham Science Publishers |
| record_format | dspace |
| spelling | upm.eprints-721632020-03-05T02:34:03Z http://psasir.upm.edu.my/id/eprint/72163/ Cytomegalovirus replication steps and the actions of antiviral drugs Abdullah, Ashwaq Ahmed Balakrishnan, Krishnan Nair Bala, Jamilu Abubakar Abdullah, Faez Firdaus Jesse Allaudin, Zeenatul Nazariah Abdullah, Rasedee Noordin, Mohamed Mustapha Mohd Lila, Mohd Azmi Human cytomegalovirus (HCMV) is a beta herpesvirus that inflicts an active infection in the fetus and immunosuppressive patients. The virus encodes many proteins that work together with cellular factors to achieve virus replication. In addition to vaccines, antiviral drugs can be deployed to manipulate how the virus replicates and minimize its pathogenicity. The five antiviral drugs approved by the Food and Drug Administration (FDA) have shown adverse reactions and the antiviral drug resistance were reported. Hence, this warrants the need for urgent development of a novel antiviral drug. Detailed understanding of the virus replication steps and how cellular signals interact with these steps will be key for pharmacological developments of for anti HCMV drugs. This review summarized all the drugs that target the virus proteins and cell signals that mediate CMV replication. Bentham Science Publishers 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72163/1/Cytomegalovirus%20replication%20steps%20and%20the%20actions%20of%20antiviral%20drugs.pdf Abdullah, Ashwaq Ahmed and Balakrishnan, Krishnan Nair and Bala, Jamilu Abubakar and Abdullah, Faez Firdaus Jesse and Allaudin, Zeenatul Nazariah and Abdullah, Rasedee and Noordin, Mohamed Mustapha and Mohd Lila, Mohd Azmi (2018) Cytomegalovirus replication steps and the actions of antiviral drugs. Anti-Infective Agents, 16 (2). 80 - 95. ISSN 2211-3525; ESSN: 2211-3533 http://www.eurekaselect.com/163113/article 10.2174/2211352516666180619155021 |
| spellingShingle | Abdullah, Ashwaq Ahmed Balakrishnan, Krishnan Nair Bala, Jamilu Abubakar Abdullah, Faez Firdaus Jesse Allaudin, Zeenatul Nazariah Abdullah, Rasedee Noordin, Mohamed Mustapha Mohd Lila, Mohd Azmi Cytomegalovirus replication steps and the actions of antiviral drugs |
| title | Cytomegalovirus replication steps and the actions of antiviral drugs |
| title_full | Cytomegalovirus replication steps and the actions of antiviral drugs |
| title_fullStr | Cytomegalovirus replication steps and the actions of antiviral drugs |
| title_full_unstemmed | Cytomegalovirus replication steps and the actions of antiviral drugs |
| title_short | Cytomegalovirus replication steps and the actions of antiviral drugs |
| title_sort | cytomegalovirus replication steps and the actions of antiviral drugs |
| url | http://psasir.upm.edu.my/id/eprint/72163/1/Cytomegalovirus%20replication%20steps%20and%20the%20actions%20of%20antiviral%20drugs.pdf |
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