Diagnostic value of myocardial deformation pattern in children with noncompaction cardiomyopathy
The current echocardiographic diagnostic criteria for noncompaction cardiomyopathy (NCC) have variable sensitivity and low specificity. Moreover, there are limited data on the use of myocardial deformation imaging for early detection of myocardial dysfunction in children with NCC. We describe left v...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Springer Verlag
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72281/1/Diagnostic%20value%20of%20myocardial%20deformation%20pattern%20in%20children%20with%20noncompaction%20cardiomyopathy.pdf |
| _version_ | 1825950059139694592 |
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| author | Yubbu, Putri Nawaytou, Hythem M. Calderon Anyosa, Renzo Banerjee, Anirban |
| author_facet | Yubbu, Putri Nawaytou, Hythem M. Calderon Anyosa, Renzo Banerjee, Anirban |
| author_sort | Yubbu, Putri |
| collection | UPM |
| description | The current echocardiographic diagnostic criteria for noncompaction cardiomyopathy (NCC) have variable sensitivity and low specificity. Moreover, there are limited data on the use of myocardial deformation imaging for early detection of myocardial dysfunction in children with NCC. We describe left ventricular (LV) deformation patterns in children with NCC, with the goal of identifying a potential diagnostic pattern. We prospectively enrolled 30 children with NCC (47% male; mean age 7.2 years) and 30 age- and gender-matched controls. Extent and severity of non compaction in each segment were evaluated in LV 16-segment model. Regional (base, mid and apex) and segmental (16 segments) longitudinal strain (LS), circumferential strain (CS) and radial strain (RS) were measured using speckle tracking echocardiography. In all patients with NCC, regional and segmental CS and RS at the apex were significantly decreased compared to controls (CS apex: − 19.2 ± 5.4% vs. − 30.2 ± 6.9%, p < 0.001/RS apex: 23.5 ± 8.6% vs. 44.1 ± 14.5%, p < 0.001). Thirty percent (9/30) of patients had an EF < 50%. In these patients, there was additional decrease in CS in basal segments and in LS in basal, mid-cavity and apical segments (CS base: − 16.4 ± 4.7% vs. − 24.6 ± 3.9%, p < 0.001/LS (average all LV segments): − 13.9 ± 3.1% vs. − 20.7 ± 4.7%, p < 0.001). A cut-off value of CS at the apex of − 24.5% was a strong differentiating feature between patients with NCC and EF > 50% and controls (sensitivity: 87%, specificity 79%, AUC 0.88, p < 0.001). Children with NCC exhibit a deformation pattern characterized by decreased apical circumferential strain, which may serve as a potential diagnostic tool for NCC. The role of decreased global LV longitudinal and basal circumferential strain should be further evaluated as a potential prognostic tool. |
| first_indexed | 2024-03-06T10:08:49Z |
| format | Article |
| id | upm.eprints-72281 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:08:49Z |
| publishDate | 2018 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | upm.eprints-722812020-04-29T06:23:51Z http://psasir.upm.edu.my/id/eprint/72281/ Diagnostic value of myocardial deformation pattern in children with noncompaction cardiomyopathy Yubbu, Putri Nawaytou, Hythem M. Calderon Anyosa, Renzo Banerjee, Anirban The current echocardiographic diagnostic criteria for noncompaction cardiomyopathy (NCC) have variable sensitivity and low specificity. Moreover, there are limited data on the use of myocardial deformation imaging for early detection of myocardial dysfunction in children with NCC. We describe left ventricular (LV) deformation patterns in children with NCC, with the goal of identifying a potential diagnostic pattern. We prospectively enrolled 30 children with NCC (47% male; mean age 7.2 years) and 30 age- and gender-matched controls. Extent and severity of non compaction in each segment were evaluated in LV 16-segment model. Regional (base, mid and apex) and segmental (16 segments) longitudinal strain (LS), circumferential strain (CS) and radial strain (RS) were measured using speckle tracking echocardiography. In all patients with NCC, regional and segmental CS and RS at the apex were significantly decreased compared to controls (CS apex: − 19.2 ± 5.4% vs. − 30.2 ± 6.9%, p < 0.001/RS apex: 23.5 ± 8.6% vs. 44.1 ± 14.5%, p < 0.001). Thirty percent (9/30) of patients had an EF < 50%. In these patients, there was additional decrease in CS in basal segments and in LS in basal, mid-cavity and apical segments (CS base: − 16.4 ± 4.7% vs. − 24.6 ± 3.9%, p < 0.001/LS (average all LV segments): − 13.9 ± 3.1% vs. − 20.7 ± 4.7%, p < 0.001). A cut-off value of CS at the apex of − 24.5% was a strong differentiating feature between patients with NCC and EF > 50% and controls (sensitivity: 87%, specificity 79%, AUC 0.88, p < 0.001). Children with NCC exhibit a deformation pattern characterized by decreased apical circumferential strain, which may serve as a potential diagnostic tool for NCC. The role of decreased global LV longitudinal and basal circumferential strain should be further evaluated as a potential prognostic tool. Springer Verlag 2018-10 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72281/1/Diagnostic%20value%20of%20myocardial%20deformation%20pattern%20in%20children%20with%20noncompaction%20cardiomyopathy.pdf Yubbu, Putri and Nawaytou, Hythem M. and Calderon Anyosa, Renzo and Banerjee, Anirban (2018) Diagnostic value of myocardial deformation pattern in children with noncompaction cardiomyopathy. The International Journal of Cardiovascular Imaging, 34 (10). 1529 - 1539. ISSN 1569-5794; ESSN: 1573-0743 https://link.springer.com/article/10.1007/s10554-018-1367-4 10.1007/s10554-018-1367-4 |
| spellingShingle | Yubbu, Putri Nawaytou, Hythem M. Calderon Anyosa, Renzo Banerjee, Anirban Diagnostic value of myocardial deformation pattern in children with noncompaction cardiomyopathy |
| title | Diagnostic value of myocardial deformation pattern in children with noncompaction cardiomyopathy |
| title_full | Diagnostic value of myocardial deformation pattern in children with noncompaction cardiomyopathy |
| title_fullStr | Diagnostic value of myocardial deformation pattern in children with noncompaction cardiomyopathy |
| title_full_unstemmed | Diagnostic value of myocardial deformation pattern in children with noncompaction cardiomyopathy |
| title_short | Diagnostic value of myocardial deformation pattern in children with noncompaction cardiomyopathy |
| title_sort | diagnostic value of myocardial deformation pattern in children with noncompaction cardiomyopathy |
| url | http://psasir.upm.edu.my/id/eprint/72281/1/Diagnostic%20value%20of%20myocardial%20deformation%20pattern%20in%20children%20with%20noncompaction%20cardiomyopathy.pdf |
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