Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age
Exposure to secondhand smoke (SHS) can affect fetal brain development as well as subsequent neurodevelopment. This study aimed to determine the association between prenatal and postnatal SHS exposure with children's neurodevelopment at 2 years of age. Among 107 mother-child pairs from a Malaysi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72356/1/Early%20life%20secondhand%20smoke%20exposure%20assessed%20by%20hair%20nicotine%20biomarker%20.pdf |
| _version_ | 1825950071114432512 |
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| author | Mohamed, Nur Nadia Loy, See Ling Lim, Poh Ying Al Mamun, Abdullah Jan Mohamed, Hamid Jan |
| author_facet | Mohamed, Nur Nadia Loy, See Ling Lim, Poh Ying Al Mamun, Abdullah Jan Mohamed, Hamid Jan |
| author_sort | Mohamed, Nur Nadia |
| collection | UPM |
| description | Exposure to secondhand smoke (SHS) can affect fetal brain development as well as subsequent neurodevelopment. This study aimed to determine the association between prenatal and postnatal SHS exposure with children's neurodevelopment at 2 years of age. Among 107 mother-child pairs from a Malaysia prospective cohort, prenatal and postnatal SHS exposure was determined based on maternal and child hair nicotine concentrations. Multiple linear regressions were used to determine the association between prenatal and postnatal levels of nicotine in maternal and children's' hair with children's neurodevelopment. After adjustment for confounders, prenatal nicotine concentration levels were negatively associated with communication (β = − 2.059; p = 0.015) and fine motor skills (β = − 2.120; p = 0.002) while postnatal nicotine concentration levels were inversely associated with fine motors (β = − 0.124; p = 0.004) and problem solving skills (β = − 0.117; p = 0.013). In conclusion, this study suggests that early life exposure to SHS may affect children's neurodevelopment. |
| first_indexed | 2024-03-06T10:09:00Z |
| format | Article |
| id | upm.eprints-72356 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:09:00Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-723562020-05-19T02:52:11Z http://psasir.upm.edu.my/id/eprint/72356/ Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age Mohamed, Nur Nadia Loy, See Ling Lim, Poh Ying Al Mamun, Abdullah Jan Mohamed, Hamid Jan Exposure to secondhand smoke (SHS) can affect fetal brain development as well as subsequent neurodevelopment. This study aimed to determine the association between prenatal and postnatal SHS exposure with children's neurodevelopment at 2 years of age. Among 107 mother-child pairs from a Malaysia prospective cohort, prenatal and postnatal SHS exposure was determined based on maternal and child hair nicotine concentrations. Multiple linear regressions were used to determine the association between prenatal and postnatal levels of nicotine in maternal and children's' hair with children's neurodevelopment. After adjustment for confounders, prenatal nicotine concentration levels were negatively associated with communication (β = − 2.059; p = 0.015) and fine motor skills (β = − 2.120; p = 0.002) while postnatal nicotine concentration levels were inversely associated with fine motors (β = − 0.124; p = 0.004) and problem solving skills (β = − 0.117; p = 0.013). In conclusion, this study suggests that early life exposure to SHS may affect children's neurodevelopment. Elsevier 2018-01 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72356/1/Early%20life%20secondhand%20smoke%20exposure%20assessed%20by%20hair%20nicotine%20biomarker%20.pdf Mohamed, Nur Nadia and Loy, See Ling and Lim, Poh Ying and Al Mamun, Abdullah and Jan Mohamed, Hamid Jan (2018) Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age. Science of the Total Environment, 610-611. 147 - 153. ISSN 0048-9697; ESSN: 1879-1026 https://www.sciencedirect.com/science/article/pii/S0048969717320284 10.1016/j.scitotenv.2017.08.030 |
| spellingShingle | Mohamed, Nur Nadia Loy, See Ling Lim, Poh Ying Al Mamun, Abdullah Jan Mohamed, Hamid Jan Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age |
| title | Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age |
| title_full | Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age |
| title_fullStr | Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age |
| title_full_unstemmed | Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age |
| title_short | Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age |
| title_sort | early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children s neurodevelopment at 2 years of age |
| url | http://psasir.upm.edu.my/id/eprint/72356/1/Early%20life%20secondhand%20smoke%20exposure%20assessed%20by%20hair%20nicotine%20biomarker%20.pdf |
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