Estimating the refractive index of oxygenated and deoxygenated hemoglobin using genetic algorithm – support vector regression model
Background and objectives: The refractive index of hemoglobin plays important role in hematology due to its strong correlation with the pathophysiology of different diseases. Measurement of the real part of the refractive index remains a challenge due to strong absorption of the hemoglobin especiall...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72613/1/Estimating%20the%20refractive%20index%20of%20oxygenated%20and%20deoxygenated%20hemoglobin%20using%20genetic%20algorithm%20.pdf |
| _version_ | 1796979490172174336 |
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| author | Alade, Ibrahim Olanrewaju Bagudu, Aliyu Oyehan, Tajudeen A. Abd Rahman, Mohd Amiruddin Saleh, Tawfik A. Olatunjif, Sunday Olusanya |
| author_facet | Alade, Ibrahim Olanrewaju Bagudu, Aliyu Oyehan, Tajudeen A. Abd Rahman, Mohd Amiruddin Saleh, Tawfik A. Olatunjif, Sunday Olusanya |
| author_sort | Alade, Ibrahim Olanrewaju |
| collection | UPM |
| description | Background and objectives: The refractive index of hemoglobin plays important role in hematology due to its strong correlation with the pathophysiology of different diseases. Measurement of the real part of the refractive index remains a challenge due to strong absorption of the hemoglobin especially at relevant high physiological concentrations. So far, only a few studies on direct measurement of refractive index have been reported and there are no firm agreements on the reported values of refractive index of hemoglobin due to measurement artifacts. In addition, it is time consuming, laborious and expensive to perform several experiments to obtain the refractive index of hemoglobin. In this work, we proposed a very rapid and accurate computational intelligent approach using Genetic Algorithm/Support Vector Regression models to estimate the real part of the refractive index for oxygenated and deoxygenated hemoglobin samples. Methods: These models utilized experimental data of wavelengths and hemoglobin concentrations in building highly accurate Genetic Algorithm/Support Vector Regression model (GA-SVR).Results:The developed methodology showed high accuracy as indicated by the low root mean square error values of 4.65 × 10−4 and 4.62 × 10−4 for oxygenated and deoxygenated hemoglobin, respectively. In addition, the models exhibited 99.85 and 99.84% correlation coefficients (r) for the oxygenated and deoxygenated hemoglobin, thus, validating the strong agreement between the predicted and the experimental results. Conclusions: Due to the accuracy and relative simplicity of the proposed models, we envisage that these models would serve as important references for future studies on optical properties of blood. |
| first_indexed | 2024-03-06T10:09:41Z |
| format | Article |
| id | upm.eprints-72613 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:09:41Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-726132020-11-11T11:13:53Z http://psasir.upm.edu.my/id/eprint/72613/ Estimating the refractive index of oxygenated and deoxygenated hemoglobin using genetic algorithm – support vector regression model Alade, Ibrahim Olanrewaju Bagudu, Aliyu Oyehan, Tajudeen A. Abd Rahman, Mohd Amiruddin Saleh, Tawfik A. Olatunjif, Sunday Olusanya Background and objectives: The refractive index of hemoglobin plays important role in hematology due to its strong correlation with the pathophysiology of different diseases. Measurement of the real part of the refractive index remains a challenge due to strong absorption of the hemoglobin especially at relevant high physiological concentrations. So far, only a few studies on direct measurement of refractive index have been reported and there are no firm agreements on the reported values of refractive index of hemoglobin due to measurement artifacts. In addition, it is time consuming, laborious and expensive to perform several experiments to obtain the refractive index of hemoglobin. In this work, we proposed a very rapid and accurate computational intelligent approach using Genetic Algorithm/Support Vector Regression models to estimate the real part of the refractive index for oxygenated and deoxygenated hemoglobin samples. Methods: These models utilized experimental data of wavelengths and hemoglobin concentrations in building highly accurate Genetic Algorithm/Support Vector Regression model (GA-SVR).Results:The developed methodology showed high accuracy as indicated by the low root mean square error values of 4.65 × 10−4 and 4.62 × 10−4 for oxygenated and deoxygenated hemoglobin, respectively. In addition, the models exhibited 99.85 and 99.84% correlation coefficients (r) for the oxygenated and deoxygenated hemoglobin, thus, validating the strong agreement between the predicted and the experimental results. Conclusions: Due to the accuracy and relative simplicity of the proposed models, we envisage that these models would serve as important references for future studies on optical properties of blood. Elsevier 2018-09 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72613/1/Estimating%20the%20refractive%20index%20of%20oxygenated%20and%20deoxygenated%20hemoglobin%20using%20genetic%20algorithm%20.pdf Alade, Ibrahim Olanrewaju and Bagudu, Aliyu and Oyehan, Tajudeen A. and Abd Rahman, Mohd Amiruddin and Saleh, Tawfik A. and Olatunjif, Sunday Olusanya (2018) Estimating the refractive index of oxygenated and deoxygenated hemoglobin using genetic algorithm – support vector regression model. Computer Methods and Programs in Biomedicine, 163. 135 - 142. ISSN 0169-2607 https://www.sciencedirect.com/science/article/abs/pii/S0169260718301871 10.1016/j.cmpb.2018.05.029 |
| spellingShingle | Alade, Ibrahim Olanrewaju Bagudu, Aliyu Oyehan, Tajudeen A. Abd Rahman, Mohd Amiruddin Saleh, Tawfik A. Olatunjif, Sunday Olusanya Estimating the refractive index of oxygenated and deoxygenated hemoglobin using genetic algorithm – support vector regression model |
| title | Estimating the refractive index of oxygenated and deoxygenated hemoglobin using genetic algorithm – support vector regression model |
| title_full | Estimating the refractive index of oxygenated and deoxygenated hemoglobin using genetic algorithm – support vector regression model |
| title_fullStr | Estimating the refractive index of oxygenated and deoxygenated hemoglobin using genetic algorithm – support vector regression model |
| title_full_unstemmed | Estimating the refractive index of oxygenated and deoxygenated hemoglobin using genetic algorithm – support vector regression model |
| title_short | Estimating the refractive index of oxygenated and deoxygenated hemoglobin using genetic algorithm – support vector regression model |
| title_sort | estimating the refractive index of oxygenated and deoxygenated hemoglobin using genetic algorithm support vector regression model |
| url | http://psasir.upm.edu.my/id/eprint/72613/1/Estimating%20the%20refractive%20index%20of%20oxygenated%20and%20deoxygenated%20hemoglobin%20using%20genetic%20algorithm%20.pdf |
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