Apoptosis as a mechanism of the cancer chemopreventive activity of glucosinolates: a review
Cruciferous vegetables are a rich source of glucosinolates that have established anti-carcinogenic activity. Naturally-occurring glucosinolates and their derivative isothiocyanates (ITCs), generated as a result of their enzymatic degradation catalysed by myrosinase, have been linked to low cancer in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Asian Pacific Organization for Cancer Prevention
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/73173/1/APOPTOSIS.pdf |
| _version_ | 1825950172794847232 |
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| author | Abdull Razis, Ahmad Faizal Arumugam, Asvinidevi |
| author_facet | Abdull Razis, Ahmad Faizal Arumugam, Asvinidevi |
| author_sort | Abdull Razis, Ahmad Faizal |
| collection | UPM |
| description | Cruciferous vegetables are a rich source of glucosinolates that have established anti-carcinogenic activity. Naturally-occurring glucosinolates and their derivative isothiocyanates (ITCs), generated as a result of their enzymatic degradation catalysed by myrosinase, have been linked to low cancer incidence in epidemiological studies, and in animal models isothiocyanates suppressed chemically-induced tumorigenesis. The prospective effect of isothiocyanates as anti-carcinogenic agent has been much explored as cytotoxic against wide array of cancer cell lines and being explored for the development of new anticancer drugs. However, the mechanisms of isothiocyanates in inducing
apoptosis against tumor cell lines are still largely disregarded. A number of mechanisms are believed to be involved in the glucosinolate-induced suppression of carcinogenesis, including the induction of apoptosis, biotransformation of xenobiotic metabolism, oxidative stress, alteration of caspase activity, angiogenesis, histone deacytylation and cell cycle arrest. The molecular mechanisms through which isothiocyanates stimulate apoptosis in cancer cell lines have not so far been clearly defined. This review summarizes the underlying mechanisms through which isothiocyanates modify the apoptotic pathway leading to cell death. |
| first_indexed | 2024-03-06T10:10:33Z |
| format | Article |
| id | upm.eprints-73173 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:10:33Z |
| publishDate | 2018 |
| publisher | Asian Pacific Organization for Cancer Prevention |
| record_format | dspace |
| spelling | upm.eprints-731732020-11-30T07:54:15Z http://psasir.upm.edu.my/id/eprint/73173/ Apoptosis as a mechanism of the cancer chemopreventive activity of glucosinolates: a review Abdull Razis, Ahmad Faizal Arumugam, Asvinidevi Cruciferous vegetables are a rich source of glucosinolates that have established anti-carcinogenic activity. Naturally-occurring glucosinolates and their derivative isothiocyanates (ITCs), generated as a result of their enzymatic degradation catalysed by myrosinase, have been linked to low cancer incidence in epidemiological studies, and in animal models isothiocyanates suppressed chemically-induced tumorigenesis. The prospective effect of isothiocyanates as anti-carcinogenic agent has been much explored as cytotoxic against wide array of cancer cell lines and being explored for the development of new anticancer drugs. However, the mechanisms of isothiocyanates in inducing apoptosis against tumor cell lines are still largely disregarded. A number of mechanisms are believed to be involved in the glucosinolate-induced suppression of carcinogenesis, including the induction of apoptosis, biotransformation of xenobiotic metabolism, oxidative stress, alteration of caspase activity, angiogenesis, histone deacytylation and cell cycle arrest. The molecular mechanisms through which isothiocyanates stimulate apoptosis in cancer cell lines have not so far been clearly defined. This review summarizes the underlying mechanisms through which isothiocyanates modify the apoptotic pathway leading to cell death. Asian Pacific Organization for Cancer Prevention 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73173/1/APOPTOSIS.pdf Abdull Razis, Ahmad Faizal and Arumugam, Asvinidevi (2018) Apoptosis as a mechanism of the cancer chemopreventive activity of glucosinolates: a review. Asian Pacific Journal of Cancer Prevention, 19 (6). 1439 - 1448. ISSN 1513-7368; ESSN: 2476-762X https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103590/pdf/APJCP-19-1439.pdf 10.22034/APJCP.2018.19.6.1439 |
| spellingShingle | Abdull Razis, Ahmad Faizal Arumugam, Asvinidevi Apoptosis as a mechanism of the cancer chemopreventive activity of glucosinolates: a review |
| title | Apoptosis as a mechanism of the cancer chemopreventive activity of glucosinolates: a review |
| title_full | Apoptosis as a mechanism of the cancer chemopreventive activity of glucosinolates: a review |
| title_fullStr | Apoptosis as a mechanism of the cancer chemopreventive activity of glucosinolates: a review |
| title_full_unstemmed | Apoptosis as a mechanism of the cancer chemopreventive activity of glucosinolates: a review |
| title_short | Apoptosis as a mechanism of the cancer chemopreventive activity of glucosinolates: a review |
| title_sort | apoptosis as a mechanism of the cancer chemopreventive activity of glucosinolates a review |
| url | http://psasir.upm.edu.my/id/eprint/73173/1/APOPTOSIS.pdf |
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