Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review
Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA sta...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Multidisciplinary Digital Publishing Institute (MDPI)
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/73291/1/BLOOD.pdf |
| _version_ | 1825950180724178944 |
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| author | Mat Daud, Zulfitri 'Azuan Karuppiah, Thilakavathy Narayanan, Sreelakshmi Sankara Chinna, Karuthan Abdul Gafor, Abdul Halim Khosla, Pramod Khor, Ban Hock Sundram, Kalyana |
| author_facet | Mat Daud, Zulfitri 'Azuan Karuppiah, Thilakavathy Narayanan, Sreelakshmi Sankara Chinna, Karuthan Abdul Gafor, Abdul Halim Khosla, Pramod Khor, Ban Hock Sundram, Kalyana |
| author_sort | Mat Daud, Zulfitri 'Azuan |
| collection | UPM |
| description | Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA status of DP from different countries, (ii) compare blood FA composition between healthy controls and DP, and (iii) evaluate FA profile and clinical endpoints in DP. Fifty-three articles from 1980 onwards, reporting FA profile in hemodialysis and peritoneal DP, were identified from PubMed, Embase, and the Cochrane library. Studies on pediatric, predialysis chronic kidney disease, acute kidney injury, and transplant patients were excluded. Moderate to high levels of n-3 polyunsaturated fatty acids (PUFA) were reported in Japan, Korea, Denmark, and Sweden. Compared to healthy adults, DP had lower proportions of n-3 and n-6 PUFA, but higher proportion of monounsaturated fatty acids. Two studies reported inverse associations between n-3 PUFAs and risks of sudden cardiac death, while one reported eicosapentaenoic acid + docosahexaenoic acid)/arachidonic acid ratio was inversely associated with cardiovascular events. The relationship between all-cause mortality and blood FA composition in DP remained inconclusive. The current evidence highlights a critical role for essential FA in nutritional management of DP. |
| first_indexed | 2024-03-06T10:10:41Z |
| format | Article |
| id | upm.eprints-73291 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:10:41Z |
| publishDate | 2018 |
| publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
| record_format | dspace |
| spelling | upm.eprints-732912020-11-30T08:32:51Z http://psasir.upm.edu.my/id/eprint/73291/ Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review Mat Daud, Zulfitri 'Azuan Karuppiah, Thilakavathy Narayanan, Sreelakshmi Sankara Chinna, Karuthan Abdul Gafor, Abdul Halim Khosla, Pramod Khor, Ban Hock Sundram, Kalyana Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA status of DP from different countries, (ii) compare blood FA composition between healthy controls and DP, and (iii) evaluate FA profile and clinical endpoints in DP. Fifty-three articles from 1980 onwards, reporting FA profile in hemodialysis and peritoneal DP, were identified from PubMed, Embase, and the Cochrane library. Studies on pediatric, predialysis chronic kidney disease, acute kidney injury, and transplant patients were excluded. Moderate to high levels of n-3 polyunsaturated fatty acids (PUFA) were reported in Japan, Korea, Denmark, and Sweden. Compared to healthy adults, DP had lower proportions of n-3 and n-6 PUFA, but higher proportion of monounsaturated fatty acids. Two studies reported inverse associations between n-3 PUFAs and risks of sudden cardiac death, while one reported eicosapentaenoic acid + docosahexaenoic acid)/arachidonic acid ratio was inversely associated with cardiovascular events. The relationship between all-cause mortality and blood FA composition in DP remained inconclusive. The current evidence highlights a critical role for essential FA in nutritional management of DP. Multidisciplinary Digital Publishing Institute (MDPI) 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73291/1/BLOOD.pdf Mat Daud, Zulfitri 'Azuan and Karuppiah, Thilakavathy and Narayanan, Sreelakshmi Sankara and Chinna, Karuthan and Abdul Gafor, Abdul Halim and Khosla, Pramod and Khor, Ban Hock and Sundram, Kalyana (2018) Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review. Nutrients, 10 (10). art. no. 1353. pp. 1-21. ISSN 2072-6643 https://pubmed.ncbi.nlm.nih.gov/30248953/ 10.3390/nu10101353 |
| spellingShingle | Mat Daud, Zulfitri 'Azuan Karuppiah, Thilakavathy Narayanan, Sreelakshmi Sankara Chinna, Karuthan Abdul Gafor, Abdul Halim Khosla, Pramod Khor, Ban Hock Sundram, Kalyana Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review |
| title | Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review |
| title_full | Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review |
| title_fullStr | Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review |
| title_full_unstemmed | Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review |
| title_short | Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review |
| title_sort | blood fatty acid status and clinical outcomes in dialysis patients a systematic review |
| url | http://psasir.upm.edu.my/id/eprint/73291/1/BLOOD.pdf |
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