Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection
Gastrointestinal nematode infection is one of the major diseases affecting small ruminants. Although some breeds of goats are quite resistant, many breeds of goats are relatively susceptible. This study used a combined parasitological, immunological, bioinformatic and statistical approach to examine...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/73295/1/GOAT.pdf |
| _version_ | 1796979558973440000 |
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| author | Md Isa, Nur Mahiza Basripuzi, N. Hayyan Salisi, Mohd Shahrom Busin, Valentina Cairns, Callum Jenvey, Caitlin Stear, Michael J. |
| author_facet | Md Isa, Nur Mahiza Basripuzi, N. Hayyan Salisi, Mohd Shahrom Busin, Valentina Cairns, Callum Jenvey, Caitlin Stear, Michael J. |
| author_sort | Md Isa, Nur Mahiza |
| collection | UPM |
| description | Gastrointestinal nematode infection is one of the major diseases affecting small ruminants. Although some breeds of goats are quite resistant, many breeds of goats are relatively susceptible. This study used a combined parasitological, immunological, bioinformatic and statistical approach to examine the role of goat IgA and eosinophils in protection against Teladorsagia circumcincta. Molecular modelling suggested that the transmembrane domain of the high affinity IgA receptor was dysfunctional in goats. Statistical analyses failed to find any association in naturally infected goats between high IgA or eosinophil responses and low faecal egg counts. Together these results indicate that IgA and eosinophil responses against T. circumcincta are less effective in goats than sheep. |
| first_indexed | 2024-03-06T10:10:41Z |
| format | Article |
| id | upm.eprints-73295 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:10:41Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-732952020-11-30T08:23:03Z http://psasir.upm.edu.my/id/eprint/73295/ Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection Md Isa, Nur Mahiza Basripuzi, N. Hayyan Salisi, Mohd Shahrom Busin, Valentina Cairns, Callum Jenvey, Caitlin Stear, Michael J. Gastrointestinal nematode infection is one of the major diseases affecting small ruminants. Although some breeds of goats are quite resistant, many breeds of goats are relatively susceptible. This study used a combined parasitological, immunological, bioinformatic and statistical approach to examine the role of goat IgA and eosinophils in protection against Teladorsagia circumcincta. Molecular modelling suggested that the transmembrane domain of the high affinity IgA receptor was dysfunctional in goats. Statistical analyses failed to find any association in naturally infected goats between high IgA or eosinophil responses and low faecal egg counts. Together these results indicate that IgA and eosinophil responses against T. circumcincta are less effective in goats than sheep. Elsevier 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73295/1/GOAT.pdf Md Isa, Nur Mahiza and Basripuzi, N. Hayyan and Salisi, Mohd Shahrom and Busin, Valentina and Cairns, Callum and Jenvey, Caitlin and Stear, Michael J. (2018) Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection. Veterinary Parasitology, 264. 18 - 25. ISSN 0304-4017; ESSN: 1873-2550 https://www.sciencedirect.com/science/article/abs/pii/S0304401718303510#! 10.1016/j.vetpar.2018.10.014 |
| spellingShingle | Md Isa, Nur Mahiza Basripuzi, N. Hayyan Salisi, Mohd Shahrom Busin, Valentina Cairns, Callum Jenvey, Caitlin Stear, Michael J. Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection |
| title | Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection |
| title_full | Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection |
| title_fullStr | Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection |
| title_full_unstemmed | Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection |
| title_short | Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection |
| title_sort | boer goats appear to lack a functional iga and eosinophil response against natural nematode infection |
| url | http://psasir.upm.edu.my/id/eprint/73295/1/GOAT.pdf |
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