Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients
Context: Rash and oral mucositis are major non-haematological adverse events (AEs) of docetaxel, in addition to fatigue, nausea, vomiting and diarrhoea, which restrict the use of the drug in cancer therapy. Alpha-1-acid glycoprotein (AAG) is an acute phase reactant glycoprotein and is a primary carr...
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/73537/1/Plasma%20alpha-1-acid%20glycoprotein%20as%20a%20potential%20predictive%20biomarker%20for%20non-haematological%20adverse%20events%20of%20docetaxel%20in%20breast%20cancer%20patients.pdf |
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| author | Jabir, Rafid Salim Gwo, Fuang Ho Ahmad Annuar, Muhammad Azrif Stanslas, Johnson |
| author_facet | Jabir, Rafid Salim Gwo, Fuang Ho Ahmad Annuar, Muhammad Azrif Stanslas, Johnson |
| author_sort | Jabir, Rafid Salim |
| collection | UPM |
| description | Context: Rash and oral mucositis are major non-haematological adverse events (AEs) of docetaxel, in addition to fatigue, nausea, vomiting and diarrhoea, which restrict the use of the drug in cancer therapy. Alpha-1-acid glycoprotein (AAG) is an acute phase reactant glycoprotein and is a primary carrier of docetaxel in the blood. Docetaxel has extensive binding (>98%) to plasma proteins such as AAG, lipoproteins and albumin. Objective: To study the association between plasma AAG level and non-haematological AEs of docetaxel in Malaysian breast cancer patients of three major ethnic groups (Malays, Chinese and Indians). Materials and methods: One hundred and twenty Malaysian breast cancer patients receiving docetaxel as single agent chemotherapy were investigated for AAG plasma level using enzyme-linked immunosorbent assay technique. Toxicity assessment was determined using Common Terminology Criteria of Adverse Events v4.0. The association between AAG and toxicity were then established. Results: There was interethnic variation of plasma AAG level; it was 182 ± 85 mg/dl in Chinese, 237 ± 94 mg/dl in Malays and 240 ± 83 mg/dl in Indians. It was found that low plasma levels of AAG were significantly associated with oral mucositis and rash. Conclusions: This study proposes plasma AAG as a potential predictive biomarker of docetaxel non-haematological AEs namely oral mucositis and rash. |
| first_indexed | 2024-03-06T10:11:05Z |
| format | Article |
| id | upm.eprints-73537 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:11:05Z |
| publishDate | 2018 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | upm.eprints-735372020-06-08T18:50:56Z http://psasir.upm.edu.my/id/eprint/73537/ Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients Jabir, Rafid Salim Gwo, Fuang Ho Ahmad Annuar, Muhammad Azrif Stanslas, Johnson Context: Rash and oral mucositis are major non-haematological adverse events (AEs) of docetaxel, in addition to fatigue, nausea, vomiting and diarrhoea, which restrict the use of the drug in cancer therapy. Alpha-1-acid glycoprotein (AAG) is an acute phase reactant glycoprotein and is a primary carrier of docetaxel in the blood. Docetaxel has extensive binding (>98%) to plasma proteins such as AAG, lipoproteins and albumin. Objective: To study the association between plasma AAG level and non-haematological AEs of docetaxel in Malaysian breast cancer patients of three major ethnic groups (Malays, Chinese and Indians). Materials and methods: One hundred and twenty Malaysian breast cancer patients receiving docetaxel as single agent chemotherapy were investigated for AAG plasma level using enzyme-linked immunosorbent assay technique. Toxicity assessment was determined using Common Terminology Criteria of Adverse Events v4.0. The association between AAG and toxicity were then established. Results: There was interethnic variation of plasma AAG level; it was 182 ± 85 mg/dl in Chinese, 237 ± 94 mg/dl in Malays and 240 ± 83 mg/dl in Indians. It was found that low plasma levels of AAG were significantly associated with oral mucositis and rash. Conclusions: This study proposes plasma AAG as a potential predictive biomarker of docetaxel non-haematological AEs namely oral mucositis and rash. Taylor & Francis 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73537/1/Plasma%20alpha-1-acid%20glycoprotein%20as%20a%20potential%20predictive%20biomarker%20for%20non-haematological%20adverse%20events%20of%20docetaxel%20in%20breast%20cancer%20patients.pdf Jabir, Rafid Salim and Gwo, Fuang Ho and Ahmad Annuar, Muhammad Azrif and Stanslas, Johnson (2018) Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients. Biomarkers, 23 (2). 142 - 146. ISSN 1354-750X, ESSN: 1366-5804 10.1080/1354750X.2017.1334152 |
| spellingShingle | Jabir, Rafid Salim Gwo, Fuang Ho Ahmad Annuar, Muhammad Azrif Stanslas, Johnson Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients |
| title | Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients |
| title_full | Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients |
| title_fullStr | Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients |
| title_full_unstemmed | Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients |
| title_short | Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients |
| title_sort | plasma alpha 1 acid glycoprotein as a potential predictive biomarker for non haematological adverse events of docetaxel in breast cancer patients |
| url | http://psasir.upm.edu.my/id/eprint/73537/1/Plasma%20alpha-1-acid%20glycoprotein%20as%20a%20potential%20predictive%20biomarker%20for%20non-haematological%20adverse%20events%20of%20docetaxel%20in%20breast%20cancer%20patients.pdf |
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