Synthesis and optimization of chitosan nanoparticles loaded with l-ascorbic acid and thymoquinone
The combination of compounds with different classes (hydrophobic and hydrophilic characters) in single chitosan carrier is a challenge due to the hydrophilicity of chitosan. Utilization of l-ascorbic acid (LAA) and thymoquinone (TQ) compounds as effective antioxidants is marred by poor bioavailabili...
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| Format: | Article |
| Language: | English |
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MDPI
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/74055/1/Synthesis%20and%20optimization%20of%20chitosan%20nanoparticles%20loaded%20with%20l-ascorbic%20acid%20and%20thymoquinone.pdf |
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| author | Othman, Nurhanisah Masarudin, Mas Jaffri Cha, Yee Kuen Dasuan, Nurul Azira Abdullah, Luqman Chuah Md. Jamil, Siti Nurul Ain |
| author_facet | Othman, Nurhanisah Masarudin, Mas Jaffri Cha, Yee Kuen Dasuan, Nurul Azira Abdullah, Luqman Chuah Md. Jamil, Siti Nurul Ain |
| author_sort | Othman, Nurhanisah |
| collection | UPM |
| description | The combination of compounds with different classes (hydrophobic and hydrophilic characters) in single chitosan carrier is a challenge due to the hydrophilicity of chitosan. Utilization of l-ascorbic acid (LAA) and thymoquinone (TQ) compounds as effective antioxidants is marred by poor bioavailability and uptake. Nanoparticles (NPs) solved the problem by functioning as a carrier for them because they have high surface areas for more efficient delivery and uptake by cells. This research, therefore, synthesized chitosan NPs (CNPs) containing LAA and TQ, CNP-LAA-TQ via ionic gelation routes as the preparation is non-toxic. They were characterized using electron microscopy, zetasizer, UV–VIS spectrophotometry, and infrared spectroscopy. The optimum CNP-LAA-TQ size produced was 141.5 ± 7.8 nm, with a polydispersity index (PDI) of 0.207 ± 0.013. The encapsulation efficiency of CNP-LAA-TQ was 22.8 ± 3.2% for LAA and 35.6 ± 3.6% for TQ. Combined hydrophilic LAA and hydrophobic TQ proved that a myriad of highly efficacious compounds with poor systemic uptake could be encapsulated together in NP systems to increase their pharmaceutical efficiency, indirectly contributing to the advancement of medical and pharmaceutical sectors. |
| first_indexed | 2024-03-06T10:12:23Z |
| format | Article |
| id | upm.eprints-74055 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:12:23Z |
| publishDate | 2018 |
| publisher | MDPI |
| record_format | dspace |
| spelling | upm.eprints-740552020-04-28T03:41:01Z http://psasir.upm.edu.my/id/eprint/74055/ Synthesis and optimization of chitosan nanoparticles loaded with l-ascorbic acid and thymoquinone Othman, Nurhanisah Masarudin, Mas Jaffri Cha, Yee Kuen Dasuan, Nurul Azira Abdullah, Luqman Chuah Md. Jamil, Siti Nurul Ain The combination of compounds with different classes (hydrophobic and hydrophilic characters) in single chitosan carrier is a challenge due to the hydrophilicity of chitosan. Utilization of l-ascorbic acid (LAA) and thymoquinone (TQ) compounds as effective antioxidants is marred by poor bioavailability and uptake. Nanoparticles (NPs) solved the problem by functioning as a carrier for them because they have high surface areas for more efficient delivery and uptake by cells. This research, therefore, synthesized chitosan NPs (CNPs) containing LAA and TQ, CNP-LAA-TQ via ionic gelation routes as the preparation is non-toxic. They were characterized using electron microscopy, zetasizer, UV–VIS spectrophotometry, and infrared spectroscopy. The optimum CNP-LAA-TQ size produced was 141.5 ± 7.8 nm, with a polydispersity index (PDI) of 0.207 ± 0.013. The encapsulation efficiency of CNP-LAA-TQ was 22.8 ± 3.2% for LAA and 35.6 ± 3.6% for TQ. Combined hydrophilic LAA and hydrophobic TQ proved that a myriad of highly efficacious compounds with poor systemic uptake could be encapsulated together in NP systems to increase their pharmaceutical efficiency, indirectly contributing to the advancement of medical and pharmaceutical sectors. MDPI 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/74055/1/Synthesis%20and%20optimization%20of%20chitosan%20nanoparticles%20loaded%20with%20l-ascorbic%20acid%20and%20thymoquinone.pdf Othman, Nurhanisah and Masarudin, Mas Jaffri and Cha, Yee Kuen and Dasuan, Nurul Azira and Abdullah, Luqman Chuah and Md. Jamil, Siti Nurul Ain (2018) Synthesis and optimization of chitosan nanoparticles loaded with l-ascorbic acid and thymoquinone. Nanomaterials, 8 (920). pp. 1-19. ISSN 2079-4991; ESSN: 2079-4991 10.3390/nano8110920 |
| spellingShingle | Othman, Nurhanisah Masarudin, Mas Jaffri Cha, Yee Kuen Dasuan, Nurul Azira Abdullah, Luqman Chuah Md. Jamil, Siti Nurul Ain Synthesis and optimization of chitosan nanoparticles loaded with l-ascorbic acid and thymoquinone |
| title | Synthesis and optimization of chitosan nanoparticles loaded with l-ascorbic acid and thymoquinone |
| title_full | Synthesis and optimization of chitosan nanoparticles loaded with l-ascorbic acid and thymoquinone |
| title_fullStr | Synthesis and optimization of chitosan nanoparticles loaded with l-ascorbic acid and thymoquinone |
| title_full_unstemmed | Synthesis and optimization of chitosan nanoparticles loaded with l-ascorbic acid and thymoquinone |
| title_short | Synthesis and optimization of chitosan nanoparticles loaded with l-ascorbic acid and thymoquinone |
| title_sort | synthesis and optimization of chitosan nanoparticles loaded with l ascorbic acid and thymoquinone |
| url | http://psasir.upm.edu.my/id/eprint/74055/1/Synthesis%20and%20optimization%20of%20chitosan%20nanoparticles%20loaded%20with%20l-ascorbic%20acid%20and%20thymoquinone.pdf |
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