The role of PET/CT amyloid Imaging compared with Tc99m-HMPAO SPECT imaging for diagnosing Alzheimer's disease
Background: Imaging such as Tc99m-HMPAO single photon emission computed tomography (SPECT), and positron emission tomography/ computed tomography (PET/CT) amyloid scans are used to aid the diagnosis of Alzheimer’s disease (AD). Objective: We aimed to correlate the ability of these modalities to diff...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Malaysian Medical Association
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/74272/1/PET.pdf |
| _version_ | 1825950318369701888 |
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| author | Suppiah, Subapriya Siew, Mooi Ching Nordin, Abdul Jalil Vinjamuri, Sobhan |
| author_facet | Suppiah, Subapriya Siew, Mooi Ching Nordin, Abdul Jalil Vinjamuri, Sobhan |
| author_sort | Suppiah, Subapriya |
| collection | UPM |
| description | Background: Imaging such as Tc99m-HMPAO single photon emission computed tomography (SPECT), and positron emission tomography/ computed tomography (PET/CT) amyloid scans are used to aid the diagnosis of Alzheimer’s disease (AD). Objective: We aimed to correlate the ability of these modalities to differentiate Probable AD and Possible AD using the clinical diagnosis as a gold standard. We also investigated the correlation of severity of amyloid deposit in the brain with the diagnosis of AD. Methods: A retrospective study of 47 subjects (17 Probable AD and 30 Possible AD) who were referred for PET/CT amyloid scans to our centre was conducted. Hypoperfusion in the temporo-parietal lobes on Tc99m-HMPAO SPECT and loss of grey-white matter contrast in cortical regions on PET/CT Amyloid scans indicating the presence of amyloid β deposit were qualitatively interpreted as positive for AD. SPECT and PET/CT were also read in combination (Combo reading). The severity of amyloid β deposit was semiquantitatively assessed in a visual binary method using a scale of Grade 0-4. The severity of amyloid β deposit was assessed in a visual binary method and a semi-quantitative method using a scale of Grade 0-4.
Results: There was significant correlation of Tc99m-HMPAO
SPECT, PET/CT amyloid findings and Combo reading with AD. The sensitivity, specificity, PPV and NPV were 87.5%, 73.7%, 58.3% and 93.3% (SPECT); 62.5%, 77.4%, 58.8% and 80.0% (PET/CT) and 87.5%, 84.2%, 70.0% and 30.0% (Combo reading) respectively. The grade of amyloid deposition was not significantly correlated with AD (Spearman’s correlation, p=0.687). Conclusion: There is an incremental benefit in utilizing PET/CT amyloid imaging in cases with atypical presentation and indeterminate findings on conventional imaging of Alzheimer’s disease. |
| first_indexed | 2024-03-06T10:12:47Z |
| format | Article |
| id | upm.eprints-74272 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:12:47Z |
| publishDate | 2018 |
| publisher | Malaysian Medical Association |
| record_format | dspace |
| spelling | upm.eprints-742722021-06-21T05:49:21Z http://psasir.upm.edu.my/id/eprint/74272/ The role of PET/CT amyloid Imaging compared with Tc99m-HMPAO SPECT imaging for diagnosing Alzheimer's disease Suppiah, Subapriya Siew, Mooi Ching Nordin, Abdul Jalil Vinjamuri, Sobhan Background: Imaging such as Tc99m-HMPAO single photon emission computed tomography (SPECT), and positron emission tomography/ computed tomography (PET/CT) amyloid scans are used to aid the diagnosis of Alzheimer’s disease (AD). Objective: We aimed to correlate the ability of these modalities to differentiate Probable AD and Possible AD using the clinical diagnosis as a gold standard. We also investigated the correlation of severity of amyloid deposit in the brain with the diagnosis of AD. Methods: A retrospective study of 47 subjects (17 Probable AD and 30 Possible AD) who were referred for PET/CT amyloid scans to our centre was conducted. Hypoperfusion in the temporo-parietal lobes on Tc99m-HMPAO SPECT and loss of grey-white matter contrast in cortical regions on PET/CT Amyloid scans indicating the presence of amyloid β deposit were qualitatively interpreted as positive for AD. SPECT and PET/CT were also read in combination (Combo reading). The severity of amyloid β deposit was semiquantitatively assessed in a visual binary method using a scale of Grade 0-4. The severity of amyloid β deposit was assessed in a visual binary method and a semi-quantitative method using a scale of Grade 0-4. Results: There was significant correlation of Tc99m-HMPAO SPECT, PET/CT amyloid findings and Combo reading with AD. The sensitivity, specificity, PPV and NPV were 87.5%, 73.7%, 58.3% and 93.3% (SPECT); 62.5%, 77.4%, 58.8% and 80.0% (PET/CT) and 87.5%, 84.2%, 70.0% and 30.0% (Combo reading) respectively. The grade of amyloid deposition was not significantly correlated with AD (Spearman’s correlation, p=0.687). Conclusion: There is an incremental benefit in utilizing PET/CT amyloid imaging in cases with atypical presentation and indeterminate findings on conventional imaging of Alzheimer’s disease. Malaysian Medical Association 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/74272/1/PET.pdf Suppiah, Subapriya and Siew, Mooi Ching and Nordin, Abdul Jalil and Vinjamuri, Sobhan (2018) The role of PET/CT amyloid Imaging compared with Tc99m-HMPAO SPECT imaging for diagnosing Alzheimer's disease. Medical Journal of Malaysia, 73 (3). 141 -146. ISSN 0300-5283 https://europepmc.org/article/med/29962497 |
| spellingShingle | Suppiah, Subapriya Siew, Mooi Ching Nordin, Abdul Jalil Vinjamuri, Sobhan The role of PET/CT amyloid Imaging compared with Tc99m-HMPAO SPECT imaging for diagnosing Alzheimer's disease |
| title | The role of PET/CT amyloid Imaging compared with Tc99m-HMPAO SPECT imaging for diagnosing Alzheimer's disease |
| title_full | The role of PET/CT amyloid Imaging compared with Tc99m-HMPAO SPECT imaging for diagnosing Alzheimer's disease |
| title_fullStr | The role of PET/CT amyloid Imaging compared with Tc99m-HMPAO SPECT imaging for diagnosing Alzheimer's disease |
| title_full_unstemmed | The role of PET/CT amyloid Imaging compared with Tc99m-HMPAO SPECT imaging for diagnosing Alzheimer's disease |
| title_short | The role of PET/CT amyloid Imaging compared with Tc99m-HMPAO SPECT imaging for diagnosing Alzheimer's disease |
| title_sort | role of pet ct amyloid imaging compared with tc99m hmpao spect imaging for diagnosing alzheimer s disease |
| url | http://psasir.upm.edu.my/id/eprint/74272/1/PET.pdf |
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