The role, involvement and function(s) of interleukin-35 and interleukin-37 in disease pathogenesis
The recently identified cytokines—interleukin (IL)-35 and interleukin (IL)-37—have been described for their anti-inflammatory and immune-modulating actions in numerous inflammatory diseases, auto-immune disorders, malignancies, infectious diseases and sepsis. Either cytokine has been reported to be...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/74275/1/The%20role%2C%20involvement%20and%20function%28s%29%20of%20interleukin-35%20and%20interleukin-37%20in%20disease%20pathogenesis.pdf |
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| author | Bello, Ramatu Omenesa Chin, Voon Kin Abd Rachman Isnadi, Mohammad Faruq Abd Majid, Roslaini Abdullah, Maizaton Atmadini Lee, Tze Yan Zakaria, Zainul Amiruddin Hussain, Mohd Khairi Basir, Rusliza |
| author_facet | Bello, Ramatu Omenesa Chin, Voon Kin Abd Rachman Isnadi, Mohammad Faruq Abd Majid, Roslaini Abdullah, Maizaton Atmadini Lee, Tze Yan Zakaria, Zainul Amiruddin Hussain, Mohd Khairi Basir, Rusliza |
| author_sort | Bello, Ramatu Omenesa |
| collection | UPM |
| description | The recently identified cytokines—interleukin (IL)-35 and interleukin (IL)-37—have been described for their anti-inflammatory and immune-modulating actions in numerous inflammatory
diseases, auto-immune disorders, malignancies, infectious diseases and sepsis. Either cytokine has been reported to be reduced and in some cases elevated and consequently contributed towards disease pathogenesis. In view of the recent advances in utilizing cytokine profiles for the development of biological macromolecules, beneficial in the management of certain intractable immune-mediated disorders, these recently characterized cytokines (IL-35 and IL-37) offer potential as reasonable targets for the discovery of novel immune-modulating anti-inflammatory therapies. A detailed comprehension of their sophisticated regulatory mechanisms and patterns of expression may provide unique opportunities for clinical application as highly selective and target specific therapeutic agents. This review seeks to summarize the recent advancements in discerning the dynamics,
mechanisms, immunoregulatory and anti-inflammatory actions of IL-35 and IL-37 as they relate to disease pathogenesis. |
| first_indexed | 2024-03-06T10:12:47Z |
| format | Article |
| id | upm.eprints-74275 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:12:47Z |
| publishDate | 2018 |
| publisher | MDPI |
| record_format | dspace |
| spelling | upm.eprints-742752020-04-02T07:30:26Z http://psasir.upm.edu.my/id/eprint/74275/ The role, involvement and function(s) of interleukin-35 and interleukin-37 in disease pathogenesis Bello, Ramatu Omenesa Chin, Voon Kin Abd Rachman Isnadi, Mohammad Faruq Abd Majid, Roslaini Abdullah, Maizaton Atmadini Lee, Tze Yan Zakaria, Zainul Amiruddin Hussain, Mohd Khairi Basir, Rusliza The recently identified cytokines—interleukin (IL)-35 and interleukin (IL)-37—have been described for their anti-inflammatory and immune-modulating actions in numerous inflammatory diseases, auto-immune disorders, malignancies, infectious diseases and sepsis. Either cytokine has been reported to be reduced and in some cases elevated and consequently contributed towards disease pathogenesis. In view of the recent advances in utilizing cytokine profiles for the development of biological macromolecules, beneficial in the management of certain intractable immune-mediated disorders, these recently characterized cytokines (IL-35 and IL-37) offer potential as reasonable targets for the discovery of novel immune-modulating anti-inflammatory therapies. A detailed comprehension of their sophisticated regulatory mechanisms and patterns of expression may provide unique opportunities for clinical application as highly selective and target specific therapeutic agents. This review seeks to summarize the recent advancements in discerning the dynamics, mechanisms, immunoregulatory and anti-inflammatory actions of IL-35 and IL-37 as they relate to disease pathogenesis. MDPI 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/74275/1/The%20role%2C%20involvement%20and%20function%28s%29%20of%20interleukin-35%20and%20interleukin-37%20in%20disease%20pathogenesis.pdf Bello, Ramatu Omenesa and Chin, Voon Kin and Abd Rachman Isnadi, Mohammad Faruq and Abd Majid, Roslaini and Abdullah, Maizaton Atmadini and Lee, Tze Yan and Zakaria, Zainul Amiruddin and Hussain, Mohd Khairi and Basir, Rusliza (2018) The role, involvement and function(s) of interleukin-35 and interleukin-37 in disease pathogenesis. International Journal of Molecular Sciences, 19. art. no. 1149. pp. 1-28. ISSN 1661-6596; EISSN: 1422-0067 https://www.mdpi.com/journal/ijms 10.3390/ijms19041149 |
| spellingShingle | Bello, Ramatu Omenesa Chin, Voon Kin Abd Rachman Isnadi, Mohammad Faruq Abd Majid, Roslaini Abdullah, Maizaton Atmadini Lee, Tze Yan Zakaria, Zainul Amiruddin Hussain, Mohd Khairi Basir, Rusliza The role, involvement and function(s) of interleukin-35 and interleukin-37 in disease pathogenesis |
| title | The role, involvement and function(s) of interleukin-35 and interleukin-37 in disease pathogenesis |
| title_full | The role, involvement and function(s) of interleukin-35 and interleukin-37 in disease pathogenesis |
| title_fullStr | The role, involvement and function(s) of interleukin-35 and interleukin-37 in disease pathogenesis |
| title_full_unstemmed | The role, involvement and function(s) of interleukin-35 and interleukin-37 in disease pathogenesis |
| title_short | The role, involvement and function(s) of interleukin-35 and interleukin-37 in disease pathogenesis |
| title_sort | role involvement and function s of interleukin 35 and interleukin 37 in disease pathogenesis |
| url | http://psasir.upm.edu.my/id/eprint/74275/1/The%20role%2C%20involvement%20and%20function%28s%29%20of%20interleukin-35%20and%20interleukin-37%20in%20disease%20pathogenesis.pdf |
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