In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor
A series of thirty-four diarylpentanoids derivatives were synthesized and evaluated for their α-glucosidase inhibitory activity. Eleven compounds (19, 20, 21, 24, 27, 28, 29, 31, 32, 33 and 34) were found to significantly inhibit α-glucosidase in which compounds 28, 31 and 32 demonstrated the highes...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/74616/1/In%20vitro%20and%20in%20silico.pdf |
| _version_ | 1796979744127844352 |
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| author | Leong, Sze Wei Abas, Faridah Lam, Kok Wai Yusoff, Khatijah |
| author_facet | Leong, Sze Wei Abas, Faridah Lam, Kok Wai Yusoff, Khatijah |
| author_sort | Leong, Sze Wei |
| collection | UPM |
| description | A series of thirty-four diarylpentanoids derivatives were synthesized and evaluated for their α-glucosidase inhibitory activity. Eleven compounds (19, 20, 21, 24, 27, 28, 29, 31, 32, 33 and 34) were found to significantly inhibit α-glucosidase in which compounds 28, 31 and 32 demonstrated the highest activity with IC50 values ranging from 14.1 to 15.1 µM. Structure-activity comparison shows that multiple hydroxy groups are essential for α-glucosidase inhibitory activity. Meanwhile, 3,4-dihydroxyphenyl and furanyl moieties were found to be crucial in improving α-glucosidase inhibition. Molecular docking analyses further confirmed the critical role of both 3,4-dihydroxyphenyl and furanyl moieties as they bound to α-glucosidase active site in different mode. Overall result suggests that diarylpentanoids with both five membered heterocyclic ring and polyhydroxyphenyl moiety could be a new lead design in the search of novel α-glucosidase inhibitor. |
| first_indexed | 2024-03-06T10:13:24Z |
| format | Article |
| id | upm.eprints-74616 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:13:24Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-746162020-12-10T20:51:02Z http://psasir.upm.edu.my/id/eprint/74616/ In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor Leong, Sze Wei Abas, Faridah Lam, Kok Wai Yusoff, Khatijah A series of thirty-four diarylpentanoids derivatives were synthesized and evaluated for their α-glucosidase inhibitory activity. Eleven compounds (19, 20, 21, 24, 27, 28, 29, 31, 32, 33 and 34) were found to significantly inhibit α-glucosidase in which compounds 28, 31 and 32 demonstrated the highest activity with IC50 values ranging from 14.1 to 15.1 µM. Structure-activity comparison shows that multiple hydroxy groups are essential for α-glucosidase inhibitory activity. Meanwhile, 3,4-dihydroxyphenyl and furanyl moieties were found to be crucial in improving α-glucosidase inhibition. Molecular docking analyses further confirmed the critical role of both 3,4-dihydroxyphenyl and furanyl moieties as they bound to α-glucosidase active site in different mode. Overall result suggests that diarylpentanoids with both five membered heterocyclic ring and polyhydroxyphenyl moiety could be a new lead design in the search of novel α-glucosidase inhibitor. Elsevier 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/74616/1/In%20vitro%20and%20in%20silico.pdf Leong, Sze Wei and Abas, Faridah and Lam, Kok Wai and Yusoff, Khatijah (2018) In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor. Bioorganic & Medicinal Chemistry Letters, 28 (3). 302 - 309. ISSN 0960-894X; ESSN:1464-3405 https://www.sciencedirect.com/science/article/abs/pii/S0960894X17312222#! 10.1016/j.bmcl.2017.12.048 |
| spellingShingle | Leong, Sze Wei Abas, Faridah Lam, Kok Wai Yusoff, Khatijah In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor |
| title | In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor |
| title_full | In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor |
| title_fullStr | In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor |
| title_full_unstemmed | In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor |
| title_short | In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor |
| title_sort | in vitro and in silico evaluations of diarylpentanoid series as a glucosidase inhibitor |
| url | http://psasir.upm.edu.my/id/eprint/74616/1/In%20vitro%20and%20in%20silico.pdf |
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