Lactococcus lactis: LAB model organism for bacteria-mediated therapeutic strategies
Lactococcus lactis is a well-characterized, food-grade lactic acid bacterium (LAB) with generally recognized as safe (GRAS) status. Better understanding of this bacterium at a molecular level has led to the development of unprecedented genetic tools that enable the expression of heterologous protein...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/74817/1/Lactococcus%20lactis.pdf |
| _version_ | 1825950381581008896 |
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| author | Faudzi, Hanis Faroque, Habibah Suet, Lin Chia Abdul Rahim, Raha Othman, Siti Sarah |
| author_facet | Faudzi, Hanis Faroque, Habibah Suet, Lin Chia Abdul Rahim, Raha Othman, Siti Sarah |
| author_sort | Faudzi, Hanis |
| collection | UPM |
| description | Lactococcus lactis is a well-characterized, food-grade lactic acid bacterium (LAB) with generally recognized as safe (GRAS) status. Better understanding of this bacterium at a molecular level has led to the development of unprecedented genetic tools that enable the expression of heterologous proteins. Subsequently, the ability of L. lactis to express and deliver these proteins to eukaryotic hosts presents a promising approach to achieve potent treatments for various diseases. Here, we have reviewed the characteristics of L. lactis and the expression systems established for this LAB model organism. We also described the experimental applications of L. lactis in disease therapy, especially its role as a vector in vaccination strategies. |
| first_indexed | 2024-03-06T10:13:44Z |
| format | Article |
| id | upm.eprints-74817 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:13:44Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | upm.eprints-748172020-03-17T08:12:12Z http://psasir.upm.edu.my/id/eprint/74817/ Lactococcus lactis: LAB model organism for bacteria-mediated therapeutic strategies Faudzi, Hanis Faroque, Habibah Suet, Lin Chia Abdul Rahim, Raha Othman, Siti Sarah Lactococcus lactis is a well-characterized, food-grade lactic acid bacterium (LAB) with generally recognized as safe (GRAS) status. Better understanding of this bacterium at a molecular level has led to the development of unprecedented genetic tools that enable the expression of heterologous proteins. Subsequently, the ability of L. lactis to express and deliver these proteins to eukaryotic hosts presents a promising approach to achieve potent treatments for various diseases. Here, we have reviewed the characteristics of L. lactis and the expression systems established for this LAB model organism. We also described the experimental applications of L. lactis in disease therapy, especially its role as a vector in vaccination strategies. 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/74817/1/Lactococcus%20lactis.pdf Faudzi, Hanis and Faroque, Habibah and Suet, Lin Chia and Abdul Rahim, Raha and Othman, Siti Sarah (2018) Lactococcus lactis: LAB model organism for bacteria-mediated therapeutic strategies. Asia-Pacific Journal of Molecular Biology and Biotechnology, 26 (1). pp. 1-10. ISSN 0128-7451 10.35118/apjmbb.2018.026.1.01 |
| spellingShingle | Faudzi, Hanis Faroque, Habibah Suet, Lin Chia Abdul Rahim, Raha Othman, Siti Sarah Lactococcus lactis: LAB model organism for bacteria-mediated therapeutic strategies |
| title | Lactococcus lactis: LAB model organism for bacteria-mediated therapeutic strategies |
| title_full | Lactococcus lactis: LAB model organism for bacteria-mediated therapeutic strategies |
| title_fullStr | Lactococcus lactis: LAB model organism for bacteria-mediated therapeutic strategies |
| title_full_unstemmed | Lactococcus lactis: LAB model organism for bacteria-mediated therapeutic strategies |
| title_short | Lactococcus lactis: LAB model organism for bacteria-mediated therapeutic strategies |
| title_sort | lactococcus lactis lab model organism for bacteria mediated therapeutic strategies |
| url | http://psasir.upm.edu.my/id/eprint/74817/1/Lactococcus%20lactis.pdf |
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