Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology
Red palm oil (RPO) is a natural source of Vitamin E (70–80% tocotrienol). It is a potent natural antioxidant that can be used in skin-care products. Its antioxidant property protects skin from inflammation and aging. In our work, a tocotrienol-rich RPO-based nanoemulsion formulation was optimized us...
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| Format: | Article |
| Language: | English |
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Public Library of Science
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/75164/1/Optimization%20of%20process%20parameters%20in%20preparation%20of%20tocotrienol.pdf |
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| author | Chong, Wai Ting Tan, Chin Ping Cheah, Yoke Kqueen Lajis, Ahmad Firdaus Mat Dian, Noor Lida Habi Kanagaratnam, Sivaruby Lai, Oi Ming |
| author_facet | Chong, Wai Ting Tan, Chin Ping Cheah, Yoke Kqueen Lajis, Ahmad Firdaus Mat Dian, Noor Lida Habi Kanagaratnam, Sivaruby Lai, Oi Ming |
| author_sort | Chong, Wai Ting |
| collection | UPM |
| description | Red palm oil (RPO) is a natural source of Vitamin E (70–80% tocotrienol). It is a potent natural antioxidant that can be used in skin-care products. Its antioxidant property protects skin from inflammation and aging. In our work, a tocotrienol-rich RPO-based nanoemulsion formulation was optimized using response surface methodology (RSM) and formulated using high pressure homogenizer. Effect of the concentration of three independent variables [surfactant (5–15 wt%), co-solvent (10–30 wt%) and homogenization pressure (500–700 bar)] toward two response variables (droplet size, polydispersity index) was studied using central composite design (CCD) coupled to RSM. RSM analysis showed that the experimental data could be fitted into a second-order polynomial model and the coefficients of multiple determination (R2) is 0.9115. The optimized formulation of RPO-based nanoemulsion consisted of 6.09 wt% mixed surfactant [Tween 80/Span 80 (63:37, wt)], 20 wt% glycerol as a co-solvent via homogenization pressure (500 bar). The optimized tocotrienol-rich RPO-based nanoemulsion response values for droplet size and polydispersity index were 119.49nm and 0.286, respectively. The actual values of the formulated nanoemulsion were in good agreement with the predicted values obtained from RSM, thus the optimized compositions have the potential to be used as a nanoemulsion for cosmetic formulations. |
| first_indexed | 2024-03-06T10:14:21Z |
| format | Article |
| id | upm.eprints-75164 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:14:21Z |
| publishDate | 2018 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | upm.eprints-751642019-11-27T03:42:12Z http://psasir.upm.edu.my/id/eprint/75164/ Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology Chong, Wai Ting Tan, Chin Ping Cheah, Yoke Kqueen Lajis, Ahmad Firdaus Mat Dian, Noor Lida Habi Kanagaratnam, Sivaruby Lai, Oi Ming Red palm oil (RPO) is a natural source of Vitamin E (70–80% tocotrienol). It is a potent natural antioxidant that can be used in skin-care products. Its antioxidant property protects skin from inflammation and aging. In our work, a tocotrienol-rich RPO-based nanoemulsion formulation was optimized using response surface methodology (RSM) and formulated using high pressure homogenizer. Effect of the concentration of three independent variables [surfactant (5–15 wt%), co-solvent (10–30 wt%) and homogenization pressure (500–700 bar)] toward two response variables (droplet size, polydispersity index) was studied using central composite design (CCD) coupled to RSM. RSM analysis showed that the experimental data could be fitted into a second-order polynomial model and the coefficients of multiple determination (R2) is 0.9115. The optimized formulation of RPO-based nanoemulsion consisted of 6.09 wt% mixed surfactant [Tween 80/Span 80 (63:37, wt)], 20 wt% glycerol as a co-solvent via homogenization pressure (500 bar). The optimized tocotrienol-rich RPO-based nanoemulsion response values for droplet size and polydispersity index were 119.49nm and 0.286, respectively. The actual values of the formulated nanoemulsion were in good agreement with the predicted values obtained from RSM, thus the optimized compositions have the potential to be used as a nanoemulsion for cosmetic formulations. Public Library of Science 2018-08-24 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/75164/1/Optimization%20of%20process%20parameters%20in%20preparation%20of%20tocotrienol.pdf Chong, Wai Ting and Tan, Chin Ping and Cheah, Yoke Kqueen and Lajis, Ahmad Firdaus and Mat Dian, Noor Lida Habi and Kanagaratnam, Sivaruby and Lai, Oi Ming (2018) Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology. PLoS One, 13 (8). pp. 1-22. ISSN 1932-6203 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202771 10.1371/journal.pone.0202771 |
| spellingShingle | Chong, Wai Ting Tan, Chin Ping Cheah, Yoke Kqueen Lajis, Ahmad Firdaus Mat Dian, Noor Lida Habi Kanagaratnam, Sivaruby Lai, Oi Ming Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology |
| title | Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology |
| title_full | Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology |
| title_fullStr | Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology |
| title_full_unstemmed | Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology |
| title_short | Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology |
| title_sort | optimization of process parameters in preparation of tocotrienol rich red palm oil based nanoemulsion stabilized by tween80 span 80 using response surface methodology |
| url | http://psasir.upm.edu.my/id/eprint/75164/1/Optimization%20of%20process%20parameters%20in%20preparation%20of%20tocotrienol.pdf |
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