The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis
Human cartilage contains multipotent stem cells, namely mesenchymal stem cells (MSCs) which are progenitors of connective tissue that play homeostatic and reparative roles. Although the major constituent cells in the cartilage are chondrocytes, they possess a limited regenerative ability, and as a r...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/77944/1/2020042010381637_MJMHS_0147.pdf |
| _version_ | 1825950938765983744 |
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| author | Al-Graittee, Satar Jabbar Rahi Ramasamy, Rajesh |
| author_facet | Al-Graittee, Satar Jabbar Rahi Ramasamy, Rajesh |
| author_sort | Al-Graittee, Satar Jabbar Rahi |
| collection | UPM |
| description | Human cartilage contains multipotent stem cells, namely mesenchymal stem cells (MSCs) which are progenitors of connective tissue that play homeostatic and reparative roles. Although the major constituent cells in the cartilage are chondrocytes, they possess a limited regenerative ability, and as a result, spontaneous cartilage repair by chondrocytes leads to the synthesis of fibrocartilage. Similarly, MSCs derived from articular cartilage of osteoarthritis patients have demonstrated inadequacy in cartilage repair. The role of MSCs in the pathophysiology of osteoarthritis (OA) is not entirely understood, whether the inflammatory milieu associated with OA joints affects the reparative properties of MSCs or the inherent defects of OA cartilage-derived MSCs impair the proper execution of the required immunosuppressive and reparative functions. Therefore, the current review explores the biological characteristics and features of MSCs derived from physiological state and OA condition with the aim of identifying how OA affects MSC functions as well as the role of MSCs in the pathophysiology of OA. |
| first_indexed | 2024-03-06T10:22:16Z |
| format | Article |
| id | upm.eprints-77944 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:22:16Z |
| publishDate | 2020 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-779442020-05-04T17:48:51Z http://psasir.upm.edu.my/id/eprint/77944/ The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis Al-Graittee, Satar Jabbar Rahi Ramasamy, Rajesh Human cartilage contains multipotent stem cells, namely mesenchymal stem cells (MSCs) which are progenitors of connective tissue that play homeostatic and reparative roles. Although the major constituent cells in the cartilage are chondrocytes, they possess a limited regenerative ability, and as a result, spontaneous cartilage repair by chondrocytes leads to the synthesis of fibrocartilage. Similarly, MSCs derived from articular cartilage of osteoarthritis patients have demonstrated inadequacy in cartilage repair. The role of MSCs in the pathophysiology of osteoarthritis (OA) is not entirely understood, whether the inflammatory milieu associated with OA joints affects the reparative properties of MSCs or the inherent defects of OA cartilage-derived MSCs impair the proper execution of the required immunosuppressive and reparative functions. Therefore, the current review explores the biological characteristics and features of MSCs derived from physiological state and OA condition with the aim of identifying how OA affects MSC functions as well as the role of MSCs in the pathophysiology of OA. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/77944/1/2020042010381637_MJMHS_0147.pdf Al-Graittee, Satar Jabbar Rahi and Ramasamy, Rajesh (2020) The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis. Malaysian Journal of Medicine and Health Sciences, 16 (2). pp. 262-268. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020042010381637_MJMHS_0147.pdf |
| spellingShingle | Al-Graittee, Satar Jabbar Rahi Ramasamy, Rajesh The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis |
| title | The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis |
| title_full | The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis |
| title_fullStr | The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis |
| title_full_unstemmed | The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis |
| title_short | The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis |
| title_sort | crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis |
| url | http://psasir.upm.edu.my/id/eprint/77944/1/2020042010381637_MJMHS_0147.pdf |
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