Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets
Immediate onset of action in a lot of cases is extensively used than ordinary therapy, however; produce tablets with acceptable features as tensile strength, suitable with acceptable industrial limits, reduced ordered unit segregation tendency, and rapidly or appropriate disintegration time, is a cl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IOP Publishing
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/79555/1/Effect%20of%20the%20applied%20pressure%20on%20the%20essential%20characteristics%20of%20sodium%20starch%20glycolate%20tablets.pdf |
| _version_ | 1796980634601652224 |
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| author | Mousa Al-Ibraheemi, Zahraa A. Mahdi, Ali Basim Taip, Farah Saleena Anuar, Mohd Shamsul |
| author_facet | Mousa Al-Ibraheemi, Zahraa A. Mahdi, Ali Basim Taip, Farah Saleena Anuar, Mohd Shamsul |
| author_sort | Mousa Al-Ibraheemi, Zahraa A. |
| collection | UPM |
| description | Immediate onset of action in a lot of cases is extensively used than ordinary therapy, however; produce tablets with acceptable features as tensile strength, suitable with acceptable industrial limits, reduced ordered unit segregation tendency, and rapidly or appropriate disintegration time, is a classic problem. Use disintegrant is considered one of corner stone to achieve pharmaceutical tablets that meet requirements of recommended tablet formulation in the markets. Sodium Starch Glycolate as an elastic material (super disintegrant) is the component of compacted tablets by direct compression in current work. Uniaxial compaction process was implemented by utilizing a universal testing machine. The tablets were compacted under applied load ranging from 75 to 375 MPa. A 13 mm diameter cylindrical die was used to characterize the compression behaviour of the 1.0 ± 0.01 g of material. Number of the evidences from this study is, the tabletted powder characteristics and the volume-pressure measurements relationship were investigated. The recommended tablet formulations were evaluated by using elastic relaxation, indirect tensile strength, friability, and disintegration tests. Applying load higher than 150 Mpa produces compacts with a longer disintegration time, low elastic relaxation, in addition to tensile strength and friability percentage identical to recommended tablets formulation in the markets. |
| first_indexed | 2024-03-06T10:25:57Z |
| format | Article |
| id | upm.eprints-79555 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:25:57Z |
| publishDate | 2019 |
| publisher | IOP Publishing |
| record_format | dspace |
| spelling | upm.eprints-795552021-06-28T09:54:45Z http://psasir.upm.edu.my/id/eprint/79555/ Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets Mousa Al-Ibraheemi, Zahraa A. Mahdi, Ali Basim Taip, Farah Saleena Anuar, Mohd Shamsul Immediate onset of action in a lot of cases is extensively used than ordinary therapy, however; produce tablets with acceptable features as tensile strength, suitable with acceptable industrial limits, reduced ordered unit segregation tendency, and rapidly or appropriate disintegration time, is a classic problem. Use disintegrant is considered one of corner stone to achieve pharmaceutical tablets that meet requirements of recommended tablet formulation in the markets. Sodium Starch Glycolate as an elastic material (super disintegrant) is the component of compacted tablets by direct compression in current work. Uniaxial compaction process was implemented by utilizing a universal testing machine. The tablets were compacted under applied load ranging from 75 to 375 MPa. A 13 mm diameter cylindrical die was used to characterize the compression behaviour of the 1.0 ± 0.01 g of material. Number of the evidences from this study is, the tabletted powder characteristics and the volume-pressure measurements relationship were investigated. The recommended tablet formulations were evaluated by using elastic relaxation, indirect tensile strength, friability, and disintegration tests. Applying load higher than 150 Mpa produces compacts with a longer disintegration time, low elastic relaxation, in addition to tensile strength and friability percentage identical to recommended tablets formulation in the markets. IOP Publishing 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/79555/1/Effect%20of%20the%20applied%20pressure%20on%20the%20essential%20characteristics%20of%20sodium%20starch%20glycolate%20tablets.pdf Mousa Al-Ibraheemi, Zahraa A. and Mahdi, Ali Basim and Taip, Farah Saleena and Anuar, Mohd Shamsul (2019) Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets. Journal of Physics: Conference Series, 1279. pp. 1-11. ISSN 1742-6588; ESSN: 1742-6596 https://iopscience.iop.org/article/10.1088/1742-6596/1279/1/012028/meta 10.1088/1742-6596/1279/1/012028 |
| spellingShingle | Mousa Al-Ibraheemi, Zahraa A. Mahdi, Ali Basim Taip, Farah Saleena Anuar, Mohd Shamsul Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets |
| title | Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets |
| title_full | Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets |
| title_fullStr | Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets |
| title_full_unstemmed | Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets |
| title_short | Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets |
| title_sort | effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets |
| url | http://psasir.upm.edu.my/id/eprint/79555/1/Effect%20of%20the%20applied%20pressure%20on%20the%20essential%20characteristics%20of%20sodium%20starch%20glycolate%20tablets.pdf |
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