FEV1 and total cardiovascular mortality and morbidity over an 18 years follow-up population-based prospective EPIC-NORFOLK study
Background Our study aimed to determine the association between forced expiratory volume in one second (FEV1) and subsequent fatal and non-fatal events in a general population. Methods The Norfolk (UK) based European Prospective Investigation into Cancer (EPIC-Norfolk) recruited 25,639 particip...
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| Format: | Article |
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BioMed Central
2019
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| _version_ | 1825951225362776064 |
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| author | Ching, Siew Mooi Chia, Yook Chin Lentjes, Marleen A. H. Luben, Robert Wareham, Nicholas Khaw, Kay Tee |
| author_facet | Ching, Siew Mooi Chia, Yook Chin Lentjes, Marleen A. H. Luben, Robert Wareham, Nicholas Khaw, Kay Tee |
| author_sort | Ching, Siew Mooi |
| collection | UPM |
| description | Background
Our study aimed to determine the association between forced expiratory volume in one second (FEV1) and subsequent fatal and non-fatal events in a general population.
Methods
The Norfolk (UK) based European Prospective Investigation into Cancer (EPIC-Norfolk) recruited 25,639 participants between 1993 and 1997. FEV1 measured by portable spirometry, was categorized into sex-specific quintiles. Mortality and morbidity from all causes, cardiovascular disease (CVD) and respiratory disease were collected from 1997 up to 2015. Cox proportional hazard regression analysis was used with adjustment for socio-economic factors, physical activity and co-morbidities.
Results
Mean age of the population was 58.7 ± 9.3 years, mean FEV1 for men was 294± 74 cL/s and 214± 52 cL/s for women. The adjusted hazard ratios for all-cause mortality for participants in the highest fifth of the FEV1 category was 0.63 (0.52, 0.76) for men and 0.62 (0.51, 0.76) for women compared to the lowest quintile. Adjusted HRs for every 70 cL/s increase in FEV1 among men and women were 0.77 (p < 0.001) and 0.68 (p < 0.001) for total mortality, 0.85 (p<0.001) and 0.77 (p<0.001) for CVD and 0.52 (p <0.001) and 0.42 (p <0.001) for respiratory disease.
Conclusions
Participants with higher FEV1 levels had a lower risk of CVD and all-cause mortality. Measuring the FEV1 with a portable handheld spirometry measurement may be used as a surrogate marker for cardiovascular risk. Every effort should be made to identify those with poorer lung function even in the absence of cardiovascular disease as they are at greater risk of total and CV mortality. |
| first_indexed | 2024-03-06T10:26:45Z |
| format | Article |
| id | upm.eprints-79893 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T10:26:45Z |
| publishDate | 2019 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | upm.eprints-798932023-03-23T03:02:47Z http://psasir.upm.edu.my/id/eprint/79893/ FEV1 and total cardiovascular mortality and morbidity over an 18 years follow-up population-based prospective EPIC-NORFOLK study Ching, Siew Mooi Chia, Yook Chin Lentjes, Marleen A. H. Luben, Robert Wareham, Nicholas Khaw, Kay Tee Background Our study aimed to determine the association between forced expiratory volume in one second (FEV1) and subsequent fatal and non-fatal events in a general population. Methods The Norfolk (UK) based European Prospective Investigation into Cancer (EPIC-Norfolk) recruited 25,639 participants between 1993 and 1997. FEV1 measured by portable spirometry, was categorized into sex-specific quintiles. Mortality and morbidity from all causes, cardiovascular disease (CVD) and respiratory disease were collected from 1997 up to 2015. Cox proportional hazard regression analysis was used with adjustment for socio-economic factors, physical activity and co-morbidities. Results Mean age of the population was 58.7 ± 9.3 years, mean FEV1 for men was 294± 74 cL/s and 214± 52 cL/s for women. The adjusted hazard ratios for all-cause mortality for participants in the highest fifth of the FEV1 category was 0.63 (0.52, 0.76) for men and 0.62 (0.51, 0.76) for women compared to the lowest quintile. Adjusted HRs for every 70 cL/s increase in FEV1 among men and women were 0.77 (p < 0.001) and 0.68 (p < 0.001) for total mortality, 0.85 (p<0.001) and 0.77 (p<0.001) for CVD and 0.52 (p <0.001) and 0.42 (p <0.001) for respiratory disease. Conclusions Participants with higher FEV1 levels had a lower risk of CVD and all-cause mortality. Measuring the FEV1 with a portable handheld spirometry measurement may be used as a surrogate marker for cardiovascular risk. Every effort should be made to identify those with poorer lung function even in the absence of cardiovascular disease as they are at greater risk of total and CV mortality. BioMed Central 2019 Article PeerReviewed Ching, Siew Mooi and Chia, Yook Chin and Lentjes, Marleen A. H. and Luben, Robert and Wareham, Nicholas and Khaw, Kay Tee (2019) FEV1 and total cardiovascular mortality and morbidity over an 18 years follow-up population-based prospective EPIC-NORFOLK study. BMC Public Health, 19. art. no. 501. ISSN 1471-2458 https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-019-6818-x 10.1186/s12889-019-6818-x |
| spellingShingle | Ching, Siew Mooi Chia, Yook Chin Lentjes, Marleen A. H. Luben, Robert Wareham, Nicholas Khaw, Kay Tee FEV1 and total cardiovascular mortality and morbidity over an 18 years follow-up population-based prospective EPIC-NORFOLK study |
| title | FEV1 and total cardiovascular mortality and morbidity over an 18 years follow-up population-based prospective EPIC-NORFOLK study |
| title_full | FEV1 and total cardiovascular mortality and morbidity over an 18 years follow-up population-based prospective EPIC-NORFOLK study |
| title_fullStr | FEV1 and total cardiovascular mortality and morbidity over an 18 years follow-up population-based prospective EPIC-NORFOLK study |
| title_full_unstemmed | FEV1 and total cardiovascular mortality and morbidity over an 18 years follow-up population-based prospective EPIC-NORFOLK study |
| title_short | FEV1 and total cardiovascular mortality and morbidity over an 18 years follow-up population-based prospective EPIC-NORFOLK study |
| title_sort | fev1 and total cardiovascular mortality and morbidity over an 18 years follow up population based prospective epic norfolk study |
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