Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties
Several bioactive compounds from microalgae have demonstrated diverse biological activities with positive effects on human health. However, the potential of bioactive peptides as functional foods is still undervalued. Therefore, the exploration of microalgae strains as sources of bioactive peptides...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-Blackwell Publishing
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/80239/1/Indigenous%20marine%20diatoms%20as%20novel%20sources%20of%20bioactive%20peptides%20with%20antihypertensive%20and%20antioxidant%20properties.pdf |
| _version_ | 1796980749867417600 |
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| author | Barkia, Ines Al‐Haj, Lamya Abdul Hamid, Azizah Zakaria @ Ya, Muta Harah Saari, Nazamid Zadjali, Fahad |
| author_facet | Barkia, Ines Al‐Haj, Lamya Abdul Hamid, Azizah Zakaria @ Ya, Muta Harah Saari, Nazamid Zadjali, Fahad |
| author_sort | Barkia, Ines |
| collection | UPM |
| description | Several bioactive compounds from microalgae have demonstrated diverse biological activities with positive effects on human health. However, the potential of bioactive peptides as functional foods is still undervalued. Therefore, the exploration of microalgae strains as sources of bioactive peptides could reveal strong and unique bioactivities, especially when these marine sources have never been explored before. For this aim, protein extracts from six indigenous marine diatoms were subjected to enzymatic hydrolysis using four proteases (flavourzyme, pepsin, papain and trypsin). The hydrolysates were then tested for angiotensin converting enzyme (ACE)-inhibitory, antioxidant and antihypertensive properties. Results showed that papain hydrolysates from all microalgae strains exhibited strong ACE-inhibitory activities and antioxidant properties. In particular, protein hydrolysates from Bellerochea malleus were found to reduce blood pressure properties of 17 mmHg after 5 days of oral administration to SHR animals. These results revealed the potential of bioactive peptides from indigenous marine diatoms for use as functional foods or nutraceuticals. |
| first_indexed | 2024-03-06T10:27:38Z |
| format | Article |
| id | upm.eprints-80239 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:27:38Z |
| publishDate | 2019 |
| publisher | Wiley-Blackwell Publishing |
| record_format | dspace |
| spelling | upm.eprints-802392020-10-19T16:11:12Z http://psasir.upm.edu.my/id/eprint/80239/ Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties Barkia, Ines Al‐Haj, Lamya Abdul Hamid, Azizah Zakaria @ Ya, Muta Harah Saari, Nazamid Zadjali, Fahad Several bioactive compounds from microalgae have demonstrated diverse biological activities with positive effects on human health. However, the potential of bioactive peptides as functional foods is still undervalued. Therefore, the exploration of microalgae strains as sources of bioactive peptides could reveal strong and unique bioactivities, especially when these marine sources have never been explored before. For this aim, protein extracts from six indigenous marine diatoms were subjected to enzymatic hydrolysis using four proteases (flavourzyme, pepsin, papain and trypsin). The hydrolysates were then tested for angiotensin converting enzyme (ACE)-inhibitory, antioxidant and antihypertensive properties. Results showed that papain hydrolysates from all microalgae strains exhibited strong ACE-inhibitory activities and antioxidant properties. In particular, protein hydrolysates from Bellerochea malleus were found to reduce blood pressure properties of 17 mmHg after 5 days of oral administration to SHR animals. These results revealed the potential of bioactive peptides from indigenous marine diatoms for use as functional foods or nutraceuticals. Wiley-Blackwell Publishing 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80239/1/Indigenous%20marine%20diatoms%20as%20novel%20sources%20of%20bioactive%20peptides%20with%20antihypertensive%20and%20antioxidant%20properties.pdf Barkia, Ines and Al‐Haj, Lamya and Abdul Hamid, Azizah and Zakaria @ Ya, Muta Harah and Saari, Nazamid and Zadjali, Fahad (2019) Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties. International Journal of Food Science and Technology, 54 (5). pp. 1514-1522. ISSN 0950-5423; ESSN: 1365-2621 https://www.scopus.com/record/display.uri?eid=2-s2.0-85056117191&doi=10.1111%2fijfs.14006&origin=inward&txGid=ceed9509238d5bf9f4c94c6635a497ee 10.1111/ijfs.14006 |
| spellingShingle | Barkia, Ines Al‐Haj, Lamya Abdul Hamid, Azizah Zakaria @ Ya, Muta Harah Saari, Nazamid Zadjali, Fahad Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties |
| title | Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties |
| title_full | Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties |
| title_fullStr | Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties |
| title_full_unstemmed | Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties |
| title_short | Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties |
| title_sort | indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties |
| url | http://psasir.upm.edu.my/id/eprint/80239/1/Indigenous%20marine%20diatoms%20as%20novel%20sources%20of%20bioactive%20peptides%20with%20antihypertensive%20and%20antioxidant%20properties.pdf |
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