Induction of endoplasmic reticulum stress pathway by green tea epigallocatechin-3-gallate (EGCG) in colorectal cancer cells: activation of PERK/p-eIF2α/ATF4 and IRE1α

Induction of endoplasmic reticulum stress pathway by green tea epigallocatechin-3-gallate (EGCG) in colorectal cancer cells: activation of PERK/p-eIF2α/ATF4 and IRE1α

Epigallocatechin-3-gallate (EGCG) is the most abundant bioactive polyphenolic compound among the green tea constituents and has been identified as a potential anticancer agent in colorectal cancer (CRC) studies. This study was aimed to determine the mechanism of actions of EGCG when targeting the en...

Full description

Bibliographic Details
Main Authors:	Md Nesran, Zarith Nameyrra, Shafie, Nurul Husna, Ishak, Amirah Haziyah, Mohd Esa, Norhaizan, Ismail, Amin, Md Tohid, Siti Farah
Format:	Article
Language:	English
Published:	Hindawi 2019
Online Access:	http://psasir.upm.edu.my/id/eprint/80246/1/Induction%20of%20endoplasmic%20reticulum%20stress%20pathway%20by%20green%20tea.pdf

Similar Items

Iron chelation properties of green tea Epigallocatechin-3-Gallate (EGCG) in colorectal cancer cells: analysis on Tfr/Fth regulations and molecular docking
by: Md Nesran, Zarith Nameyrra, et al.
Published: (2020)

Role of epigallocatechin-3-gallate from green tea in iron chelation and endoplasmic reticulum stress pathway in colorectal cancer cells
by: Md Nesran, Zarith Nameyra
Published: (2018)

Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways
by: Wang Lihuai, et al.
Published: (2023-10-01)

PCV2 and PRV Coinfection Induces Endoplasmic Reticulum Stress via PERK-eIF2α-ATF4-CHOP and IRE1-XBP1-EDEM Pathways
by: Si Chen, et al.
Published: (2022-04-01)

Characterization of the Synergistic Antioxidant Activity of Epigallocatechin Gallate (EGCG) and Kaempferol
by: Qiang Zhang, et al.
Published: (2023-07-01)

Mechanism of (−)-epigallocatechin gallate (EGCG) dimerization by low-temperature plasma
by: Seungil Park, et al.
Published: (2022-09-01)

Antioxidant and antiviral activities of lipophilic epigallocatechin gallate (EGCG) derivatives
by: Ying Zhong, et al.
Published: (2012-01-01)

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility
by: Mimi A. Trinh, et al.
Published: (2012-06-01)

Epigallocatechin-3-Gallate Reduces Cd-Induced Developmental Toxicity of Bodysize in <i>Caenorhabditis elegans</i> via the PEK-1/eIF-2α/ATF-4 Pathway
by: Shuanghui Wang, et al.
Published: (2023-08-01)

Melatonin Inhibits Glucose-Induced Apoptosis in Osteoblastic Cell Line Through PERK-eIF2α-ATF4 Pathway
by: Renyi Zhou, et al.
Published: (2020-12-01)

Screening of epigallocatechin-3-gallate (EGCG) content in camellia sinensis products
by: Amran, Syazwani Itri, et al.
Published: (2018)

Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
by: Hiba Siblini, et al.
Published: (2023-01-01)

Protective Effects of Epigallocatechin Gallate (EGCG) on Endometrial, Breast, and Ovarian Cancers
by: Yun-Ju Huang, et al.
Published: (2020-10-01)

The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment
by: Víctor Marín, et al.
Published: (2023-06-01)

Topical Epigallocatechin Gallate (EGCG) 1% for Chronic Plantar Ulcers in Leprosy
by: Riyana Noor Oktaviyanti, et al.
Published: (2020-07-01)

Synthesis and Biological Testing of Novel Glucosylated Epigallocatechin Gallate (EGCG) Derivatives
by: Xin Zhang, et al.
Published: (2016-05-01)

Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway
by: Jing Sun, et al.
Published: (2021-09-01)

Monoalkylated Epigallocatechin-3-gallate (C18-EGCG) as Novel Lipophilic EGCG Derivative: Characterization and Antioxidant Evaluation
by: Cristina Minnelli, et al.
Published: (2020-03-01)

Screening of epigallocatechin-3-gallate (egcg) content in commercialized camellia sinensis products
by: Amran, Syazwani Itri, et al.
Published: (2018)

Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets
by: Wamidh H. Talib, et al.
Published: (2024-03-01)

Green Tea Catechin (-)-Epigallocatechin-3-Gallate (EGCG) Facilitates Fracture Healing
by: Sung-Yen Lin, et al.
Published: (2020-04-01)

Effects of epigallocatechin-3-gallate (EGCG) on the developmental competence of parthenogenetic embryos in pig
by: Zhao Namula, et al.
Published: (2010-11-01)

Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)
by: Mario Lorenz, et al.
Published: (2017-05-01)

In Vitro Evaluation of the Antiviral Activity of the Synthetic Epigallocatechin Gallate Analog-Epigallocatechin Gallate (EGCG) Palmitate against Porcine Reproductive and Respiratory Syndrome Virus
by: Chunjian Zhao, et al.
Published: (2014-02-01)

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase
by: Merlot, Angelica M., et al.
Published: (2016)

Sinulariolide Induced Hepatocellular Carcinoma Apoptosis through Activation of Mitochondrial-Related Apoptotic and PERK/eIF2α/ATF4/CHOP Pathway
by: Yu-Jen Wu, et al.
Published: (2013-08-01)

Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma
by: Sanghwa Kim, et al.
Published: (2021-04-01)

Identification of Epigallocatechin-3-Gallate (EGCG) from Green Tea Using Mass Spectrometry
by: Iyyakkannu Sivanesan, et al.
Published: (2022-08-01)

The Potential of Epigallocatechin-3-gallate (EGCG) as Complementary Medicine for the Treatment of Inflammatory Bowel Disease
by: Sabrina Schnur, et al.
Published: (2023-05-01)

The Potential of Epigallocatechin Gallate (EGCG) in Targeting Autophagy for Cancer Treatment: A Narrative Review
by: Elena Ferrari, et al.
Published: (2022-05-01)

Efficacy of topical epigallocatechin gallate (EGCG) 1% on the healing of chronic plantar ulcers in leprosy
by: C. R. S. Prakoeswa, et al.
Published: (2021-11-01)

Effect of Epigallocatechin gallate (EGCG) on Production of Dendritic Cells from Peripheral Blood Monocytes
by: Mohammad Ali Mofid Nakhaei, et al.
Published: (2020-11-01)

Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells
by: Terryn Christine, et al.
Published: (2008-04-01)

Computational and Biochemical Discovery of RSK2 as a Novel Target for Epigallocatechin Gallate (EGCG).
by: Hanyong Chen, et al.
Published: (2015-01-01)

Protective effects of epigallocatechin gallate (EGCG) derivatives on azoxymethane-induced colonic carcinogenesis in mice
by: Ying Zhong, et al.
Published: (2012-01-01)

ERH Interacts With EIF2α and Regulates the EIF2α/ATF4/CHOP Pathway in Bladder Cancer Cells
by: Kun Pang, et al.
Published: (2022-06-01)

Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized mice
by: Qianqian Zhang, et al.
Published: (2023-05-01)

Novel Epigallocatechin-3-Gallate (EGCG)-Loaded Mesoporous Bioglass Scaffolds for Bone Recruitment Applications
by: Shih-Fu Ou, et al.
Published: (2020-12-01)

Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age
by: Ashley Payne, et al.
Published: (2022-02-01)

The Green Tea Polyphenol Epigallocatechin-Gallate (EGCG) Interferes with Microcin E492 Amyloid Formation
by: Paulina Aguilera, et al.
Published: (2023-10-01)