Iron-associated protein interaction networks reveal the key functional modules related to survival and virulence of Pasteurella multocida
Pasteurella multocida causes respiratory infectious diseases in a multitude of birds and mammals. A number of virulence-associated genes were reported across different strains of P. multocida, including those involved in the iron transport and metabolism. Comparative iron-associated genes of P. mult...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/80330/1/Iron-associated%20protein%20interaction%20networks%20reveal%20the%20key%20functional%20modules%20related%20to%20survival%20and%20virulence%20of%20Pasteurella%20multocida.pdf |
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| author | Jatuponwiphat, Theeraphol Chumnanpuen, Pramote Othman, Siti Sarah E-kobon, Teerasak Vongsangnak, Wanwipa |
| author_facet | Jatuponwiphat, Theeraphol Chumnanpuen, Pramote Othman, Siti Sarah E-kobon, Teerasak Vongsangnak, Wanwipa |
| author_sort | Jatuponwiphat, Theeraphol |
| collection | UPM |
| description | Pasteurella multocida causes respiratory infectious diseases in a multitude of birds and mammals. A number of virulence-associated genes were reported across different strains of P. multocida, including those involved in the iron transport and metabolism. Comparative iron-associated genes of P. multocida among different animal hosts towards their interaction networks have not been fully revealed. Therefore, this study aimed to identify the iron-associated genes from core- and pan-genomes of fourteen P. multocida strains and to construct iron-associated protein interaction networks using genome-scale network analysis which might be associated with the virulence. Results showed that these fourteen strains had 1587 genes in the core-genome and 3400 genes constituting their pan-genome. Out of these, 2651 genes associated with iron transport and metabolism were selected to construct the protein interaction networks and 361 genes were incorporated into the iron-associated protein interaction network (iPIN) consisting of nine different iron-associated functional modules. After comparing with the virulence factor database (VFDB), 21 virulence-associated proteins were determined and 11 of these belonged to the heme biosynthesis module. From this study, the core heme biosynthesis module and the core outer membrane hemoglobin receptor HgbA were proposed as candidate targets to design novel antibiotics and vaccines for preventing pasteurellosis across the serotypes or animal hosts for enhanced precision agriculture to ensure sustainability in food security. |
| first_indexed | 2024-03-06T10:27:53Z |
| format | Article |
| id | upm.eprints-80330 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:27:53Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-803302020-10-21T19:27:03Z http://psasir.upm.edu.my/id/eprint/80330/ Iron-associated protein interaction networks reveal the key functional modules related to survival and virulence of Pasteurella multocida Jatuponwiphat, Theeraphol Chumnanpuen, Pramote Othman, Siti Sarah E-kobon, Teerasak Vongsangnak, Wanwipa Pasteurella multocida causes respiratory infectious diseases in a multitude of birds and mammals. A number of virulence-associated genes were reported across different strains of P. multocida, including those involved in the iron transport and metabolism. Comparative iron-associated genes of P. multocida among different animal hosts towards their interaction networks have not been fully revealed. Therefore, this study aimed to identify the iron-associated genes from core- and pan-genomes of fourteen P. multocida strains and to construct iron-associated protein interaction networks using genome-scale network analysis which might be associated with the virulence. Results showed that these fourteen strains had 1587 genes in the core-genome and 3400 genes constituting their pan-genome. Out of these, 2651 genes associated with iron transport and metabolism were selected to construct the protein interaction networks and 361 genes were incorporated into the iron-associated protein interaction network (iPIN) consisting of nine different iron-associated functional modules. After comparing with the virulence factor database (VFDB), 21 virulence-associated proteins were determined and 11 of these belonged to the heme biosynthesis module. From this study, the core heme biosynthesis module and the core outer membrane hemoglobin receptor HgbA were proposed as candidate targets to design novel antibiotics and vaccines for preventing pasteurellosis across the serotypes or animal hosts for enhanced precision agriculture to ensure sustainability in food security. Elsevier 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80330/1/Iron-associated%20protein%20interaction%20networks%20reveal%20the%20key%20functional%20modules%20related%20to%20survival%20and%20virulence%20of%20Pasteurella%20multocida.pdf Jatuponwiphat, Theeraphol and Chumnanpuen, Pramote and Othman, Siti Sarah and E-kobon, Teerasak and Vongsangnak, Wanwipa (2019) Iron-associated protein interaction networks reveal the key functional modules related to survival and virulence of Pasteurella multocida. Microbial Pathogenesis, 127. pp. 257-226. ISSN 0882-4010 https://pubmed.ncbi.nlm.nih.gov/30550841/ 10.1016/j.micpath.2018.12.013 |
| spellingShingle | Jatuponwiphat, Theeraphol Chumnanpuen, Pramote Othman, Siti Sarah E-kobon, Teerasak Vongsangnak, Wanwipa Iron-associated protein interaction networks reveal the key functional modules related to survival and virulence of Pasteurella multocida |
| title | Iron-associated protein interaction networks reveal the key functional modules related to survival and virulence of Pasteurella multocida |
| title_full | Iron-associated protein interaction networks reveal the key functional modules related to survival and virulence of Pasteurella multocida |
| title_fullStr | Iron-associated protein interaction networks reveal the key functional modules related to survival and virulence of Pasteurella multocida |
| title_full_unstemmed | Iron-associated protein interaction networks reveal the key functional modules related to survival and virulence of Pasteurella multocida |
| title_short | Iron-associated protein interaction networks reveal the key functional modules related to survival and virulence of Pasteurella multocida |
| title_sort | iron associated protein interaction networks reveal the key functional modules related to survival and virulence of pasteurella multocida |
| url | http://psasir.upm.edu.my/id/eprint/80330/1/Iron-associated%20protein%20interaction%20networks%20reveal%20the%20key%20functional%20modules%20related%20to%20survival%20and%20virulence%20of%20Pasteurella%20multocida.pdf |
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