Annexin A2 extracellular translocation and virus interaction: a potential target for antivirus‐drug discovery
Annexin A2 is a membrane scaffolding and binding protein, which mediated various cellular events. Its functions are generally affected by cellular localization. In the cytoplasm, they interacted with different phospholipid membranes in Ca2+‐dependent manner and play vital roles including actin bindi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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John Wiley and Sons
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/80651/1/ANNEXIN.pdf |
| _version_ | 1825951326304993280 |
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| author | Chee, Hui Yee Ling, King Hwa Aliyu, Isah Abubakar Md Hashim, Nur Fariesha |
| author_facet | Chee, Hui Yee Ling, King Hwa Aliyu, Isah Abubakar Md Hashim, Nur Fariesha |
| author_sort | Chee, Hui Yee |
| collection | UPM |
| description | Annexin A2 is a membrane scaffolding and binding protein, which mediated various cellular events. Its functions are generally affected by cellular localization. In the cytoplasm, they interacted with different phospholipid membranes in Ca2+‐dependent manner and play vital roles including actin binding, remodeling and dynamics, cytoskeletal rearrangement, and lipid‐raft microdomain formation. However, upon cell exposure to certain stimuli, annexin A2 translocates to the external leaflets of the plasma membrane where annexin A2 was recently reported to serve as a virus receptor, play an important role in the formation of virus replication complex, or implicated in virus assembly and budding. Here, we review some of annexin A2 roles in virus infections and the potentiality of targeting annexin A2 in the design of novel and promising antivirus agent that may have a broader consequence in virus therapy. |
| first_indexed | 2024-03-06T10:28:19Z |
| format | Article |
| id | upm.eprints-80651 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:28:19Z |
| publishDate | 2019 |
| publisher | John Wiley and Sons |
| record_format | dspace |
| spelling | upm.eprints-806512020-11-09T15:22:12Z http://psasir.upm.edu.my/id/eprint/80651/ Annexin A2 extracellular translocation and virus interaction: a potential target for antivirus‐drug discovery Chee, Hui Yee Ling, King Hwa Aliyu, Isah Abubakar Md Hashim, Nur Fariesha Annexin A2 is a membrane scaffolding and binding protein, which mediated various cellular events. Its functions are generally affected by cellular localization. In the cytoplasm, they interacted with different phospholipid membranes in Ca2+‐dependent manner and play vital roles including actin binding, remodeling and dynamics, cytoskeletal rearrangement, and lipid‐raft microdomain formation. However, upon cell exposure to certain stimuli, annexin A2 translocates to the external leaflets of the plasma membrane where annexin A2 was recently reported to serve as a virus receptor, play an important role in the formation of virus replication complex, or implicated in virus assembly and budding. Here, we review some of annexin A2 roles in virus infections and the potentiality of targeting annexin A2 in the design of novel and promising antivirus agent that may have a broader consequence in virus therapy. John Wiley and Sons 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80651/1/ANNEXIN.pdf Chee, Hui Yee and Ling, King Hwa and Aliyu, Isah Abubakar and Md Hashim, Nur Fariesha (2019) Annexin A2 extracellular translocation and virus interaction: a potential target for antivirus‐drug discovery. Reviews in Medical Virology, 29 (3). ISSN 1052-9276; ESSN: 10991654 https://onlinelibrary.wiley.com/doi/abs/10.1002/rmv.2038 10.1002/rmv.2038 |
| spellingShingle | Chee, Hui Yee Ling, King Hwa Aliyu, Isah Abubakar Md Hashim, Nur Fariesha Annexin A2 extracellular translocation and virus interaction: a potential target for antivirus‐drug discovery |
| title | Annexin A2 extracellular translocation and virus interaction: a potential target for antivirus‐drug discovery |
| title_full | Annexin A2 extracellular translocation and virus interaction: a potential target for antivirus‐drug discovery |
| title_fullStr | Annexin A2 extracellular translocation and virus interaction: a potential target for antivirus‐drug discovery |
| title_full_unstemmed | Annexin A2 extracellular translocation and virus interaction: a potential target for antivirus‐drug discovery |
| title_short | Annexin A2 extracellular translocation and virus interaction: a potential target for antivirus‐drug discovery |
| title_sort | annexin a2 extracellular translocation and virus interaction a potential target for antivirus drug discovery |
| url | http://psasir.upm.edu.my/id/eprint/80651/1/ANNEXIN.pdf |
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