Antidiabetic and antioxidants activities of Clinacanthus nutans(Burm F.) Lindau leaves extracts
Clinacanthus nutans (Acanthaceae) is a local plant consumed as tisane in Indonesia and ‘ulam’ in Malaysia. This plant has been claimed for its ability to prevent many diseases including diabetes. However, the scientific proof on this claim is still lacking. Therefore, the present work study was des...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Universiti Putra Malaysia
2019
|
| _version_ | 1796980797973987328 |
|---|---|
| author | S., Murugesu A., Khatib Z., Ibrahim Q. U., Ahmed B. F., Uzir N. I., Nik Yusoff V., Perumal Abas, Faridah Shaari, Khozirah |
| author_facet | S., Murugesu A., Khatib Z., Ibrahim Q. U., Ahmed B. F., Uzir N. I., Nik Yusoff V., Perumal Abas, Faridah Shaari, Khozirah |
| author_sort | S., Murugesu |
| collection | UPM |
| description | Clinacanthus nutans (Acanthaceae) is a local plant consumed as tisane in Indonesia and ‘ulam’ in Malaysia. This plant has been claimed for its ability to prevent many diseases including
diabetes. However, the scientific proof on this claim is still lacking. Therefore, the present work study was designed to evaluate the antidiabetic potential and antioxidant capacity of C. nutans
leaves extracts using in vitro bioassay tests. The 80% methanolic crude extract of this plant was further partitioned using different polarity solvents namely hexane, hexane:ethyl acetate (1:1,
v/v), ethyl acetate, ethyl acetate:methanol (1:1, v/v), and methanol. All the sub-fractions were analysed for antioxidant effect via 2, 2-diphenyl-2-picrylhydrazil (DPPH) scavenging activity, ferric reducing power (FRAP) and xanthine oxidase (XO) assays followed by antidiabetic evaluation via α-glucosidase and dipeptidyl peptidase-IV (DPP-IV) inhibitory assays and glucose uptake experiment. The ethyl acetate fraction showed a good antioxidant potential while the hexane fraction exhibited high α-glucosidase and DPP-IV enzyme inhibition. The hexane fraction also improved glucose uptake in a dose-dependent manner. The present work
thus provides an informative data on the potential of C. nutans to be developed as a functional food in preventing diabetes. |
| first_indexed | 2024-03-06T10:28:21Z |
| format | Article |
| id | upm.eprints-80667 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T10:28:21Z |
| publishDate | 2019 |
| publisher | Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-806672023-01-26T01:58:45Z http://psasir.upm.edu.my/id/eprint/80667/ Antidiabetic and antioxidants activities of Clinacanthus nutans(Burm F.) Lindau leaves extracts S., Murugesu A., Khatib Z., Ibrahim Q. U., Ahmed B. F., Uzir N. I., Nik Yusoff V., Perumal Abas, Faridah Shaari, Khozirah Clinacanthus nutans (Acanthaceae) is a local plant consumed as tisane in Indonesia and ‘ulam’ in Malaysia. This plant has been claimed for its ability to prevent many diseases including diabetes. However, the scientific proof on this claim is still lacking. Therefore, the present work study was designed to evaluate the antidiabetic potential and antioxidant capacity of C. nutans leaves extracts using in vitro bioassay tests. The 80% methanolic crude extract of this plant was further partitioned using different polarity solvents namely hexane, hexane:ethyl acetate (1:1, v/v), ethyl acetate, ethyl acetate:methanol (1:1, v/v), and methanol. All the sub-fractions were analysed for antioxidant effect via 2, 2-diphenyl-2-picrylhydrazil (DPPH) scavenging activity, ferric reducing power (FRAP) and xanthine oxidase (XO) assays followed by antidiabetic evaluation via α-glucosidase and dipeptidyl peptidase-IV (DPP-IV) inhibitory assays and glucose uptake experiment. The ethyl acetate fraction showed a good antioxidant potential while the hexane fraction exhibited high α-glucosidase and DPP-IV enzyme inhibition. The hexane fraction also improved glucose uptake in a dose-dependent manner. The present work thus provides an informative data on the potential of C. nutans to be developed as a functional food in preventing diabetes. Universiti Putra Malaysia 2019 Article PeerReviewed S., Murugesu and A., Khatib and Z., Ibrahim and Q. U., Ahmed and B. F., Uzir and N. I., Nik Yusoff and V., Perumal and Abas, Faridah and Shaari, Khozirah (2019) Antidiabetic and antioxidants activities of Clinacanthus nutans(Burm F.) Lindau leaves extracts. International Food Research Journal, 26 (1). pp. 319-327. ISSN 1985-4668; ESSN: 2231-7546 http://www.ifrj.upm.edu.my/ifrj-2019-26-issue-1.html |
| spellingShingle | S., Murugesu A., Khatib Z., Ibrahim Q. U., Ahmed B. F., Uzir N. I., Nik Yusoff V., Perumal Abas, Faridah Shaari, Khozirah Antidiabetic and antioxidants activities of Clinacanthus nutans(Burm F.) Lindau leaves extracts |
| title | Antidiabetic and antioxidants activities of Clinacanthus nutans(Burm F.) Lindau leaves extracts |
| title_full | Antidiabetic and antioxidants activities of Clinacanthus nutans(Burm F.) Lindau leaves extracts |
| title_fullStr | Antidiabetic and antioxidants activities of Clinacanthus nutans(Burm F.) Lindau leaves extracts |
| title_full_unstemmed | Antidiabetic and antioxidants activities of Clinacanthus nutans(Burm F.) Lindau leaves extracts |
| title_short | Antidiabetic and antioxidants activities of Clinacanthus nutans(Burm F.) Lindau leaves extracts |
| title_sort | antidiabetic and antioxidants activities of clinacanthus nutans burm f lindau leaves extracts |
| work_keys_str_mv | AT smurugesu antidiabeticandantioxidantsactivitiesofclinacanthusnutansburmflindauleavesextracts AT akhatib antidiabeticandantioxidantsactivitiesofclinacanthusnutansburmflindauleavesextracts AT zibrahim antidiabeticandantioxidantsactivitiesofclinacanthusnutansburmflindauleavesextracts AT quahmed antidiabeticandantioxidantsactivitiesofclinacanthusnutansburmflindauleavesextracts AT bfuzir antidiabeticandantioxidantsactivitiesofclinacanthusnutansburmflindauleavesextracts AT ninikyusoff antidiabeticandantioxidantsactivitiesofclinacanthusnutansburmflindauleavesextracts AT vperumal antidiabeticandantioxidantsactivitiesofclinacanthusnutansburmflindauleavesextracts AT abasfaridah antidiabeticandantioxidantsactivitiesofclinacanthusnutansburmflindauleavesextracts AT shaarikhozirah antidiabeticandantioxidantsactivitiesofclinacanthusnutansburmflindauleavesextracts |