Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb
Four carbazoles (girinimbine, mahanimbine, murrayafoline and murrayanine), isolated from Murraya koenigii, and one kavalactone (5,6-dehydrokawain) and one flavonoid (pinostrobin) isolated, from Alpinia mutica, were tested for their antitrypanosomal activity using in vitro cultured Trypanosoma evans...
| Những tác giả chính: | , , , |
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| Định dạng: | Bài viết |
| Ngôn ngữ: | English |
| Được phát hành: |
Malaysian Society of Parasitology and Tropical Medicine
2019
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| Truy cập trực tuyến: | http://psasir.upm.edu.my/id/eprint/80691/1/ROXB.pdf |
| _version_ | 1825951330591571968 |
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| author | Othman, Dyary Hiewa Abdul Kadir, Arifah Sukari, Mohd Aspollah Sharma, Reuben Sunil Kumar |
| author_facet | Othman, Dyary Hiewa Abdul Kadir, Arifah Sukari, Mohd Aspollah Sharma, Reuben Sunil Kumar |
| author_sort | Othman, Dyary Hiewa |
| collection | UPM |
| description | Four carbazoles (girinimbine, mahanimbine, murrayafoline and murrayanine), isolated from Murraya koenigii, and one kavalactone (5,6-dehydrokawain) and one flavonoid (pinostrobin) isolated, from Alpinia mutica, were tested for their antitrypanosomal activity
using in vitro cultured Trypanosoma evansi cell lines. The cytotoxic activities of these compounds were also investigated against mammalian Vero cells using the MTT (3-(4,5- Dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide)-cell proliferation assay. Three
carbazole compounds, namely mahanimbine, murrayafoline, and girinimbine, showed a potent antitrypanosomal activity, scoring a median inhibitory concentration (IC50) of 3.13, 6.35 and
10.16 µg/ml, respectively. Girinimbine was the least toxic to Vero cells, and the mean cytotoxic concentration (CC50) and the selectivity index (SI) of this compound were 745.58 ± 42.38 µg/
ml and 73.38, respectively. Girinimbine and the other carbazole compounds possess potential antitrypanosomal activity with comparably low toxicity against mammalian cells. Girinimbine,
in particular, is a good candidate to be further investigated as a potential antitrypanosomal agent using in vivo models. |
| first_indexed | 2024-03-06T10:28:23Z |
| format | Article |
| id | upm.eprints-80691 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:28:23Z |
| publishDate | 2019 |
| publisher | Malaysian Society of Parasitology and Tropical Medicine |
| record_format | dspace |
| spelling | upm.eprints-806912021-02-28T17:40:30Z http://psasir.upm.edu.my/id/eprint/80691/ Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb Othman, Dyary Hiewa Abdul Kadir, Arifah Sukari, Mohd Aspollah Sharma, Reuben Sunil Kumar Four carbazoles (girinimbine, mahanimbine, murrayafoline and murrayanine), isolated from Murraya koenigii, and one kavalactone (5,6-dehydrokawain) and one flavonoid (pinostrobin) isolated, from Alpinia mutica, were tested for their antitrypanosomal activity using in vitro cultured Trypanosoma evansi cell lines. The cytotoxic activities of these compounds were also investigated against mammalian Vero cells using the MTT (3-(4,5- Dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide)-cell proliferation assay. Three carbazole compounds, namely mahanimbine, murrayafoline, and girinimbine, showed a potent antitrypanosomal activity, scoring a median inhibitory concentration (IC50) of 3.13, 6.35 and 10.16 µg/ml, respectively. Girinimbine was the least toxic to Vero cells, and the mean cytotoxic concentration (CC50) and the selectivity index (SI) of this compound were 745.58 ± 42.38 µg/ ml and 73.38, respectively. Girinimbine and the other carbazole compounds possess potential antitrypanosomal activity with comparably low toxicity against mammalian cells. Girinimbine, in particular, is a good candidate to be further investigated as a potential antitrypanosomal agent using in vivo models. Malaysian Society of Parasitology and Tropical Medicine 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80691/1/ROXB.pdf Othman, Dyary Hiewa and Abdul Kadir, Arifah and Sukari, Mohd Aspollah and Sharma, Reuben Sunil Kumar (2019) Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb. Tropical Biomedicine, 36 (1). pp. 94-102. ISSN 0127-5720 https://www.researchgate.net/publication/329178514 |
| spellingShingle | Othman, Dyary Hiewa Abdul Kadir, Arifah Sukari, Mohd Aspollah Sharma, Reuben Sunil Kumar Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb |
| title | Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb |
| title_full | Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb |
| title_fullStr | Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb |
| title_full_unstemmed | Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb |
| title_short | Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb |
| title_sort | antitrypanosomal and cytotoxic activities of botanical extracts from murraya koenigii l and alpinia mutica roxb |
| url | http://psasir.upm.edu.my/id/eprint/80691/1/ROXB.pdf |
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