Biomaterials used in stem cell therapy for spinal cord injury
Spinal cord injury (SCI) is a common, severe damage to the central nervous system. Here, we discuss the use of biomaterials for stem cell transplantation in preclinical and clinical studies for the treatment of patients with SCI, because cell culture materials could influence the differentiation fat...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/80822/1/STEM.pdf |
| _version_ | 1825951345119592448 |
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| author | Higuchi, Akon Subbiah, Suresh Kumar Benelli, Giovanni Ling, Qing Dong Li, Hsing Fen Alarfaj, Abdullah A. Munusamy, Murugan A. Sung, Tzu Cheng Chang, Yung Murugan, Kadarkarai |
| author_facet | Higuchi, Akon Subbiah, Suresh Kumar Benelli, Giovanni Ling, Qing Dong Li, Hsing Fen Alarfaj, Abdullah A. Munusamy, Murugan A. Sung, Tzu Cheng Chang, Yung Murugan, Kadarkarai |
| author_sort | Higuchi, Akon |
| collection | UPM |
| description | Spinal cord injury (SCI) is a common, severe damage to the central nervous system. Here, we discuss the use of biomaterials for stem cell transplantation in preclinical and clinical studies for the treatment of patients with SCI, because cell culture materials could influence the differentiation fate of stem cells, and not act only as carriers or scaffolds for delivery of stem cells and their differentiated cells. Therefore, the effects of cell culture materials on stem cell differentiation fate have been discussed. A direct injection of stem cells is the easiest method to transplant stem cells into the site of SCI. However, the stem cell solution tends to leak out from the injection site. Biomaterials such as fibrin have been used to reduce scarring at the transplantation site and facilitate the integration of transplanted stem cells or progenitor cells in animal models of SCI. Transplantation of stem cells using biomaterials (scaffolds or hydrogels) has been reported to be effective for the treatment of SCI in animal models. It would be necessary to investigate the optimal chemical structure, porosity, and morphology of biomaterials used for the transplantation of stem cells. |
| first_indexed | 2024-03-06T10:28:36Z |
| format | Article |
| id | upm.eprints-80822 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:28:36Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-808222021-04-15T03:14:30Z http://psasir.upm.edu.my/id/eprint/80822/ Biomaterials used in stem cell therapy for spinal cord injury Higuchi, Akon Subbiah, Suresh Kumar Benelli, Giovanni Ling, Qing Dong Li, Hsing Fen Alarfaj, Abdullah A. Munusamy, Murugan A. Sung, Tzu Cheng Chang, Yung Murugan, Kadarkarai Spinal cord injury (SCI) is a common, severe damage to the central nervous system. Here, we discuss the use of biomaterials for stem cell transplantation in preclinical and clinical studies for the treatment of patients with SCI, because cell culture materials could influence the differentiation fate of stem cells, and not act only as carriers or scaffolds for delivery of stem cells and their differentiated cells. Therefore, the effects of cell culture materials on stem cell differentiation fate have been discussed. A direct injection of stem cells is the easiest method to transplant stem cells into the site of SCI. However, the stem cell solution tends to leak out from the injection site. Biomaterials such as fibrin have been used to reduce scarring at the transplantation site and facilitate the integration of transplanted stem cells or progenitor cells in animal models of SCI. Transplantation of stem cells using biomaterials (scaffolds or hydrogels) has been reported to be effective for the treatment of SCI in animal models. It would be necessary to investigate the optimal chemical structure, porosity, and morphology of biomaterials used for the transplantation of stem cells. Elsevier 2019-06 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80822/1/STEM.pdf Higuchi, Akon and Subbiah, Suresh Kumar and Benelli, Giovanni and Ling, Qing Dong and Li, Hsing Fen and Alarfaj, Abdullah A. and Munusamy, Murugan A. and Sung, Tzu Cheng and Chang, Yung and Murugan, Kadarkarai (2019) Biomaterials used in stem cell therapy for spinal cord injury. Progress in Materials Science, 103. pp. 374-424. ISSN 0079-6425; ESSN: 1873-2208 https://www.sciencedirect.com/science/article/pii/S0079642519300143 10.1016/j.pmatsci.2019.02.002 |
| spellingShingle | Higuchi, Akon Subbiah, Suresh Kumar Benelli, Giovanni Ling, Qing Dong Li, Hsing Fen Alarfaj, Abdullah A. Munusamy, Murugan A. Sung, Tzu Cheng Chang, Yung Murugan, Kadarkarai Biomaterials used in stem cell therapy for spinal cord injury |
| title | Biomaterials used in stem cell therapy for spinal cord injury |
| title_full | Biomaterials used in stem cell therapy for spinal cord injury |
| title_fullStr | Biomaterials used in stem cell therapy for spinal cord injury |
| title_full_unstemmed | Biomaterials used in stem cell therapy for spinal cord injury |
| title_short | Biomaterials used in stem cell therapy for spinal cord injury |
| title_sort | biomaterials used in stem cell therapy for spinal cord injury |
| url | http://psasir.upm.edu.my/id/eprint/80822/1/STEM.pdf |
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