Chemicals used for the induction of Alzheimers disease-like cognitive dysfunctions in rodents
Alzheimer's disease (AD) is the most frequent and multifactorial form of dementia, characterised by multiple cognitive impairments and personality changes. Different methods including chemicals have been used to induce AD-like symptoms in rodent in order to screen many therapeutic drugs for a v...
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| Format: | Article |
| Language: | English |
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BioMedPress
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/80931/1/ALZHEIMER.pdf |
| _version_ | 1796980831042928640 |
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| author | Mahdi, Onesimus Baharuldin, Mohamad Taufik Hidayat Mohd Nor, Nurul Huda Musa Chiroma, Samaila Jagadeesan, Saravanan Mohd Moklas, Mohamad Aris |
| author_facet | Mahdi, Onesimus Baharuldin, Mohamad Taufik Hidayat Mohd Nor, Nurul Huda Musa Chiroma, Samaila Jagadeesan, Saravanan Mohd Moklas, Mohamad Aris |
| author_sort | Mahdi, Onesimus |
| collection | UPM |
| description | Alzheimer's disease (AD) is the most frequent and multifactorial form of dementia, characterised by multiple cognitive impairments and personality changes. Different methods including chemicals have been used to induce AD-like symptoms in rodent in order to screen many therapeutic drugs for a variety of cognitive dysfunctions. Articles from reliable databases such as Google Scholar, Science Direct, PubMed, Scopus, and Ovid were searched and retrieved with the following descriptors: 'Alzheimer's Disease', Cognitive impairments', Neurotoxins that induce AD', Alzheimerogenic chemicals', excitotoxins', Amyloid beta', neurofibrillary tangles. A number of chemicals have been
studied to develop an animal model of AD on the basis of their mechanism of action for cognitive dysfunctions. Some of such chemicals are Heavy metals, Scopolamine, Ethanol, Colchicine,
Streptozotocin, Lipopolysaccharide, and Okadaic acid among others, with a view to understanding the pathogenesis of this devastating disease. The purpose of this review is to put forward some AD pathophysiology including AD causative theories and also highlight some Alzheimerogenic chemicals for the purpose of enriching our existing knowledge. It is worth mentioning that not all the biochemical, histopathological, cognitive and behavioural abnormalities can be recapitulated. Nonetheless, experimental models of AD produced by chemicals offer insights to unravelling the pathogenesis of the disease. |
| first_indexed | 2024-03-06T10:28:50Z |
| format | Article |
| id | upm.eprints-80931 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:28:50Z |
| publishDate | 2019 |
| publisher | BioMedPress |
| record_format | dspace |
| spelling | upm.eprints-809312020-10-14T21:55:50Z http://psasir.upm.edu.my/id/eprint/80931/ Chemicals used for the induction of Alzheimers disease-like cognitive dysfunctions in rodents Mahdi, Onesimus Baharuldin, Mohamad Taufik Hidayat Mohd Nor, Nurul Huda Musa Chiroma, Samaila Jagadeesan, Saravanan Mohd Moklas, Mohamad Aris Alzheimer's disease (AD) is the most frequent and multifactorial form of dementia, characterised by multiple cognitive impairments and personality changes. Different methods including chemicals have been used to induce AD-like symptoms in rodent in order to screen many therapeutic drugs for a variety of cognitive dysfunctions. Articles from reliable databases such as Google Scholar, Science Direct, PubMed, Scopus, and Ovid were searched and retrieved with the following descriptors: 'Alzheimer's Disease', Cognitive impairments', Neurotoxins that induce AD', Alzheimerogenic chemicals', excitotoxins', Amyloid beta', neurofibrillary tangles. A number of chemicals have been studied to develop an animal model of AD on the basis of their mechanism of action for cognitive dysfunctions. Some of such chemicals are Heavy metals, Scopolamine, Ethanol, Colchicine, Streptozotocin, Lipopolysaccharide, and Okadaic acid among others, with a view to understanding the pathogenesis of this devastating disease. The purpose of this review is to put forward some AD pathophysiology including AD causative theories and also highlight some Alzheimerogenic chemicals for the purpose of enriching our existing knowledge. It is worth mentioning that not all the biochemical, histopathological, cognitive and behavioural abnormalities can be recapitulated. Nonetheless, experimental models of AD produced by chemicals offer insights to unravelling the pathogenesis of the disease. BioMedPress 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80931/1/ALZHEIMER.pdf Mahdi, Onesimus and Baharuldin, Mohamad Taufik Hidayat and Mohd Nor, Nurul Huda and Musa Chiroma, Samaila and Jagadeesan, Saravanan and Mohd Moklas, Mohamad Aris (2019) Chemicals used for the induction of Alzheimers disease-like cognitive dysfunctions in rodents. Biomedical Research and Therapy, 6 (11). pp. 3460-3484. ISSN 2198-4093 https://www.researchgate.net/publication/337591449_Chemicals_used_for_the_induction_of_Alzheimer's_disease-like_cognitive_dysfunctions_in_rodents 10.15419/bmrat.v6i11.575 |
| spellingShingle | Mahdi, Onesimus Baharuldin, Mohamad Taufik Hidayat Mohd Nor, Nurul Huda Musa Chiroma, Samaila Jagadeesan, Saravanan Mohd Moklas, Mohamad Aris Chemicals used for the induction of Alzheimers disease-like cognitive dysfunctions in rodents |
| title | Chemicals used for the induction of Alzheimers disease-like cognitive dysfunctions in rodents |
| title_full | Chemicals used for the induction of Alzheimers disease-like cognitive dysfunctions in rodents |
| title_fullStr | Chemicals used for the induction of Alzheimers disease-like cognitive dysfunctions in rodents |
| title_full_unstemmed | Chemicals used for the induction of Alzheimers disease-like cognitive dysfunctions in rodents |
| title_short | Chemicals used for the induction of Alzheimers disease-like cognitive dysfunctions in rodents |
| title_sort | chemicals used for the induction of alzheimers disease like cognitive dysfunctions in rodents |
| url | http://psasir.upm.edu.my/id/eprint/80931/1/ALZHEIMER.pdf |
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