Clinicopathologic and radiographic features in 40 cats diagnosed with pulmonary and cutaneous Rhodococcus equi infection (2012-2018)
Objectives: This retrospective study aimed to describe clinical manifestations, diagnostic options, radiological features, therapeutic plans and outcomes for cats infected with Rhodococcus equi. Methods: Forty cats aged between 2 months and 11 years old (median 6 months) that were definitively diag...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sage Publications
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/80945/1/CAT.pdf |
| _version_ | 1796980833117011968 |
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| author | Aslam, Muhammad Waseem Lau, Seng Fong Chin, Chelly Sze Lee Ahmad, Nur Indah Rahman, Nor Alimah Kuppusamy, Krishnammah Omar, Sharina Radzi, Rozanaliza |
| author_facet | Aslam, Muhammad Waseem Lau, Seng Fong Chin, Chelly Sze Lee Ahmad, Nur Indah Rahman, Nor Alimah Kuppusamy, Krishnammah Omar, Sharina Radzi, Rozanaliza |
| author_sort | Aslam, Muhammad Waseem |
| collection | UPM |
| description | Objectives: This retrospective study aimed to describe clinical manifestations, diagnostic options, radiological
features, therapeutic plans and outcomes for cats infected with Rhodococcus equi. Methods: Forty cats aged between 2 months and 11 years old (median 6 months) that were definitively diagnosed with rhodococcosis between 2012 and 2018 were recruited in this study. Medical records were reviewed for information on signalment, history, clinical presentation, diagnostic testing, treatment plans and clinical outcomes. Results Of the 40 cats, 36 showed the pulmonary form of the disease, with 35 (87.5%) presenting with dyspnoea, while four cats presented with only cutaneous lesions. Mean body temperature was 38.7±0.2°C. Dyspnoea was noted in 87.5% of the cats. Leukocytosis (58.3%) with band neutrophilia (83.3%), monocytosis (58.3%) and thrombocytopenia (55.5%) were prominent findings in the haematology reports. Hyperproteinaemia (61.1%) with hypoalbuminaemia (22.2%) and hyperglobulinaemia (63.8%) with a low albumin:globulin ratio (38.9%) were prominent features of blood biochemistry reports. An alveolar–interstitial pattern was noted in 75% of prethoracocentesis radiographs. Pleural effusion, hepatomegaly, thoracic lymphadenopathy and atelectasis of any lung lobe were seen in 88.9%, 75%, 41.7% and 36.1% of cats, respectively. Overall, the mortality rate was 67.5% in both forms. Conclusions and relevance Clinicians should be aware that feline rhodococcosis manifests as a pulmonary disease at a much higher rate than previously reported. Further studies are required to address the epidemiology, pathophysiology, disease management and prognosis of feline rhodococcosis. The role of immunosuppression as a predisposing factor in feline rhodococcosis requires further investigation. |
| first_indexed | 2024-03-06T10:28:52Z |
| format | Article |
| id | upm.eprints-80945 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:28:52Z |
| publishDate | 2019 |
| publisher | Sage Publications |
| record_format | dspace |
| spelling | upm.eprints-809452020-10-15T12:58:06Z http://psasir.upm.edu.my/id/eprint/80945/ Clinicopathologic and radiographic features in 40 cats diagnosed with pulmonary and cutaneous Rhodococcus equi infection (2012-2018) Aslam, Muhammad Waseem Lau, Seng Fong Chin, Chelly Sze Lee Ahmad, Nur Indah Rahman, Nor Alimah Kuppusamy, Krishnammah Omar, Sharina Radzi, Rozanaliza Objectives: This retrospective study aimed to describe clinical manifestations, diagnostic options, radiological features, therapeutic plans and outcomes for cats infected with Rhodococcus equi. Methods: Forty cats aged between 2 months and 11 years old (median 6 months) that were definitively diagnosed with rhodococcosis between 2012 and 2018 were recruited in this study. Medical records were reviewed for information on signalment, history, clinical presentation, diagnostic testing, treatment plans and clinical outcomes. Results Of the 40 cats, 36 showed the pulmonary form of the disease, with 35 (87.5%) presenting with dyspnoea, while four cats presented with only cutaneous lesions. Mean body temperature was 38.7±0.2°C. Dyspnoea was noted in 87.5% of the cats. Leukocytosis (58.3%) with band neutrophilia (83.3%), monocytosis (58.3%) and thrombocytopenia (55.5%) were prominent findings in the haematology reports. Hyperproteinaemia (61.1%) with hypoalbuminaemia (22.2%) and hyperglobulinaemia (63.8%) with a low albumin:globulin ratio (38.9%) were prominent features of blood biochemistry reports. An alveolar–interstitial pattern was noted in 75% of prethoracocentesis radiographs. Pleural effusion, hepatomegaly, thoracic lymphadenopathy and atelectasis of any lung lobe were seen in 88.9%, 75%, 41.7% and 36.1% of cats, respectively. Overall, the mortality rate was 67.5% in both forms. Conclusions and relevance Clinicians should be aware that feline rhodococcosis manifests as a pulmonary disease at a much higher rate than previously reported. Further studies are required to address the epidemiology, pathophysiology, disease management and prognosis of feline rhodococcosis. The role of immunosuppression as a predisposing factor in feline rhodococcosis requires further investigation. Sage Publications 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80945/1/CAT.pdf Aslam, Muhammad Waseem and Lau, Seng Fong and Chin, Chelly Sze Lee and Ahmad, Nur Indah and Rahman, Nor Alimah and Kuppusamy, Krishnammah and Omar, Sharina and Radzi, Rozanaliza (2019) Clinicopathologic and radiographic features in 40 cats diagnosed with pulmonary and cutaneous Rhodococcus equi infection (2012-2018). Journal of Feline Medicine and Surgery, 22 (8). pp. 774-790. ISSN 1098-612X; ESSN: 1532-2750 https://journals.sagepub.com/doi/full/10.1177/1098612X19886395 10.1177/1098612X19886395 |
| spellingShingle | Aslam, Muhammad Waseem Lau, Seng Fong Chin, Chelly Sze Lee Ahmad, Nur Indah Rahman, Nor Alimah Kuppusamy, Krishnammah Omar, Sharina Radzi, Rozanaliza Clinicopathologic and radiographic features in 40 cats diagnosed with pulmonary and cutaneous Rhodococcus equi infection (2012-2018) |
| title | Clinicopathologic and radiographic features in 40 cats diagnosed with pulmonary and cutaneous Rhodococcus equi infection (2012-2018) |
| title_full | Clinicopathologic and radiographic features in 40 cats diagnosed with pulmonary and cutaneous Rhodococcus equi infection (2012-2018) |
| title_fullStr | Clinicopathologic and radiographic features in 40 cats diagnosed with pulmonary and cutaneous Rhodococcus equi infection (2012-2018) |
| title_full_unstemmed | Clinicopathologic and radiographic features in 40 cats diagnosed with pulmonary and cutaneous Rhodococcus equi infection (2012-2018) |
| title_short | Clinicopathologic and radiographic features in 40 cats diagnosed with pulmonary and cutaneous Rhodococcus equi infection (2012-2018) |
| title_sort | clinicopathologic and radiographic features in 40 cats diagnosed with pulmonary and cutaneous rhodococcus equi infection 2012 2018 |
| url | http://psasir.upm.edu.my/id/eprint/80945/1/CAT.pdf |
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