Co-culture systems for the production of secondary metabolites: current and future prospects

Microorganisms are the great sources of Natural Products (NPs); these are imperative to their survival apart from conferring competitiveness amongst each other within their environmental niches. Primary and secondary metabolites are the two major classes of NPs that help in cell development, where a...

Full description

Bibliographic Details
Main Authors: Zin, Quat Tan, Hui, Yin Leow, Lee, David Charles Weerasingam, Kanakeswary, Karisnan, Song, Adelene Ai Lian, Chun, Wai Mai, Wai, Sum Yap, Swee, Hua Erin Lim, Kok, Song Lai
Format: Article
Language:English
Published: Bentham Open 2019
Online Access:http://psasir.upm.edu.my/id/eprint/80952/1/MICRO.pdf
_version_ 1825951362384396288
author Zin, Quat Tan
Hui, Yin Leow
Lee, David Charles Weerasingam
Kanakeswary, Karisnan
Song, Adelene Ai Lian
Chun, Wai Mai
Wai, Sum Yap
Swee, Hua Erin Lim
Kok, Song Lai
author_facet Zin, Quat Tan
Hui, Yin Leow
Lee, David Charles Weerasingam
Kanakeswary, Karisnan
Song, Adelene Ai Lian
Chun, Wai Mai
Wai, Sum Yap
Swee, Hua Erin Lim
Kok, Song Lai
author_sort Zin, Quat Tan
collection UPM
description Microorganisms are the great sources of Natural Products (NPs); these are imperative to their survival apart from conferring competitiveness amongst each other within their environmental niches. Primary and secondary metabolites are the two major classes of NPs that help in cell development, where antimicrobial activity is closely linked with secondary metabolites. To capitalize on the effects of secondary metabolites, co-culture methods have been often used to develop an artificial microbial community that promotes the action of these metabolites. Different analytical techniques will subsequently be employed based on the metabolite specificity and sensitivity to further enhance the metabolite induction. Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography (GC)-MS are commonly used for metabolite separation while Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) have been used as tools to elucidate the structure of compounds. This review intends to discuss current systems in use for co-culture in addition to its advantages, with discourse into the investigation of specific techniques in use for the detailed study of secondary metabolites. Further advancements and focus on co-culture technologies are required to fully realize the massive potential in synthetic biological systems.
first_indexed 2024-03-06T10:28:52Z
format Article
id upm.eprints-80952
institution Universiti Putra Malaysia
language English
last_indexed 2024-03-06T10:28:52Z
publishDate 2019
publisher Bentham Open
record_format dspace
spelling upm.eprints-809522020-10-15T13:03:47Z http://psasir.upm.edu.my/id/eprint/80952/ Co-culture systems for the production of secondary metabolites: current and future prospects Zin, Quat Tan Hui, Yin Leow Lee, David Charles Weerasingam Kanakeswary, Karisnan Song, Adelene Ai Lian Chun, Wai Mai Wai, Sum Yap Swee, Hua Erin Lim Kok, Song Lai Microorganisms are the great sources of Natural Products (NPs); these are imperative to their survival apart from conferring competitiveness amongst each other within their environmental niches. Primary and secondary metabolites are the two major classes of NPs that help in cell development, where antimicrobial activity is closely linked with secondary metabolites. To capitalize on the effects of secondary metabolites, co-culture methods have been often used to develop an artificial microbial community that promotes the action of these metabolites. Different analytical techniques will subsequently be employed based on the metabolite specificity and sensitivity to further enhance the metabolite induction. Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography (GC)-MS are commonly used for metabolite separation while Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) have been used as tools to elucidate the structure of compounds. This review intends to discuss current systems in use for co-culture in addition to its advantages, with discourse into the investigation of specific techniques in use for the detailed study of secondary metabolites. Further advancements and focus on co-culture technologies are required to fully realize the massive potential in synthetic biological systems. Bentham Open 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80952/1/MICRO.pdf Zin, Quat Tan and Hui, Yin Leow and Lee, David Charles Weerasingam and Kanakeswary, Karisnan and Song, Adelene Ai Lian and Chun, Wai Mai and Wai, Sum Yap and Swee, Hua Erin Lim and Kok, Song Lai (2019) Co-culture systems for the production of secondary metabolites: current and future prospects. Open Biotechnology Journal, 13. pp. 18-26. ISSN 1874-0707 https://benthamopen.com/FULLTEXT/TOBIOTJ-13-18 10.2174/1874070701913010018
spellingShingle Zin, Quat Tan
Hui, Yin Leow
Lee, David Charles Weerasingam
Kanakeswary, Karisnan
Song, Adelene Ai Lian
Chun, Wai Mai
Wai, Sum Yap
Swee, Hua Erin Lim
Kok, Song Lai
Co-culture systems for the production of secondary metabolites: current and future prospects
title Co-culture systems for the production of secondary metabolites: current and future prospects
title_full Co-culture systems for the production of secondary metabolites: current and future prospects
title_fullStr Co-culture systems for the production of secondary metabolites: current and future prospects
title_full_unstemmed Co-culture systems for the production of secondary metabolites: current and future prospects
title_short Co-culture systems for the production of secondary metabolites: current and future prospects
title_sort co culture systems for the production of secondary metabolites current and future prospects
url http://psasir.upm.edu.my/id/eprint/80952/1/MICRO.pdf
work_keys_str_mv AT zinquattan coculturesystemsfortheproductionofsecondarymetabolitescurrentandfutureprospects
AT huiyinleow coculturesystemsfortheproductionofsecondarymetabolitescurrentandfutureprospects
AT leedavidcharlesweerasingam coculturesystemsfortheproductionofsecondarymetabolitescurrentandfutureprospects
AT kanakeswarykarisnan coculturesystemsfortheproductionofsecondarymetabolitescurrentandfutureprospects
AT songadeleneailian coculturesystemsfortheproductionofsecondarymetabolitescurrentandfutureprospects
AT chunwaimai coculturesystemsfortheproductionofsecondarymetabolitescurrentandfutureprospects
AT waisumyap coculturesystemsfortheproductionofsecondarymetabolitescurrentandfutureprospects
AT sweehuaerinlim coculturesystemsfortheproductionofsecondarymetabolitescurrentandfutureprospects
AT koksonglai coculturesystemsfortheproductionofsecondarymetabolitescurrentandfutureprospects