Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia
Increased ASM mass, primarily due to ASM hyperplasia, has been recognized as a hallmark of airway remodeling in asthma. Increased ASM mass is the major contributor to the airway narrowing, thus worsening the bronchoconstriction in response to stimuli. Inflammatory mediators and growth factors releas...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Research Foundation
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81053/1/ASM.pdf |
| _version_ | 1825951378430754816 |
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| author | Yap, Hui Min Israf Ali, Daud Ahmad Harith, Hanis Hazeera Tham, Chau Ling Sulaiman, Mohd Roslan |
| author_facet | Yap, Hui Min Israf Ali, Daud Ahmad Harith, Hanis Hazeera Tham, Chau Ling Sulaiman, Mohd Roslan |
| author_sort | Yap, Hui Min |
| collection | UPM |
| description | Increased ASM mass, primarily due to ASM hyperplasia, has been recognized as a hallmark of airway remodeling in asthma. Increased ASM mass is the major contributor to the airway narrowing, thus worsening the bronchoconstriction in response to stimuli. Inflammatory mediators and growth factors released during inflammation induce increased ASM mass surrounding airway wall via increased ASM proliferation, diminished ASM apoptosis and increased ASM migration. Several major pathways, such as MAPKs, PI3K/AKT, JAK2/STAT3 and Rho kinase, have been reported to regulate these cellular activities in ASM and were reported to be interrelated at certain points. This article aims to provide an overview of the signaling pathways/molecules involved in ASM hyperplasia as well as the mapping of the interplay/crosstalk between these major pathways in mediating ASM hyperplasia. A more comprehensive understanding of the complexity of cellular signaling in ASM cells will enable more specific and safer drug development in the control of asthma. |
| first_indexed | 2024-03-06T10:29:07Z |
| format | Article |
| id | upm.eprints-81053 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:29:07Z |
| publishDate | 2019 |
| publisher | Frontiers Research Foundation |
| record_format | dspace |
| spelling | upm.eprints-810532020-10-14T19:02:16Z http://psasir.upm.edu.my/id/eprint/81053/ Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia Yap, Hui Min Israf Ali, Daud Ahmad Harith, Hanis Hazeera Tham, Chau Ling Sulaiman, Mohd Roslan Increased ASM mass, primarily due to ASM hyperplasia, has been recognized as a hallmark of airway remodeling in asthma. Increased ASM mass is the major contributor to the airway narrowing, thus worsening the bronchoconstriction in response to stimuli. Inflammatory mediators and growth factors released during inflammation induce increased ASM mass surrounding airway wall via increased ASM proliferation, diminished ASM apoptosis and increased ASM migration. Several major pathways, such as MAPKs, PI3K/AKT, JAK2/STAT3 and Rho kinase, have been reported to regulate these cellular activities in ASM and were reported to be interrelated at certain points. This article aims to provide an overview of the signaling pathways/molecules involved in ASM hyperplasia as well as the mapping of the interplay/crosstalk between these major pathways in mediating ASM hyperplasia. A more comprehensive understanding of the complexity of cellular signaling in ASM cells will enable more specific and safer drug development in the control of asthma. Frontiers Research Foundation 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81053/1/ASM.pdf Yap, Hui Min and Israf Ali, Daud Ahmad and Harith, Hanis Hazeera and Tham, Chau Ling and Sulaiman, Mohd Roslan (2019) Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia. Frontiers in Pharmacology, 10. art. no. 1148. pp. 1-16. ISSN 1663-9812 https://www.frontiersin.org/articles/10.3389/fphar.2019.01148/full 10.3389/fphar.2019.01148 |
| spellingShingle | Yap, Hui Min Israf Ali, Daud Ahmad Harith, Hanis Hazeera Tham, Chau Ling Sulaiman, Mohd Roslan Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia |
| title | Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia |
| title_full | Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia |
| title_fullStr | Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia |
| title_full_unstemmed | Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia |
| title_short | Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia |
| title_sort | crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia |
| url | http://psasir.upm.edu.my/id/eprint/81053/1/ASM.pdf |
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