Long-term impact of bariatric surgery in diabetic nephropathy
Background: Bariatric surgery has been shown to improve and resolve diabetes. However, limited literature about its impact on end-organ complications of diabetes is available. The aim of this study was to examine the long-term effect of bariatric surgery on albuminuria. Methods: We studied 101 pa...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2019
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/81246/1/BARIATIC.pdf |
| _version_ | 1796980882337169408 |
|---|---|
| author | Young, LeAnne Nor Hanipah, Zubaidah Brethauer, Stacy A. Schauer, Philip R. Aminian, Ali |
| author_facet | Young, LeAnne Nor Hanipah, Zubaidah Brethauer, Stacy A. Schauer, Philip R. Aminian, Ali |
| author_sort | Young, LeAnne |
| collection | UPM |
| description | Background: Bariatric surgery has been shown to improve and resolve diabetes. However, limited literature about its impact on end-organ complications of diabetes is available. The aim of this study was to examine the long-term effect of bariatric surgery on albuminuria.
Methods: We studied 101 patients with pre-operative diabetes and albuminuria [defined as urine albumin:creatinine ratio (uACR) > 30 mg/g] who underwent bariatric surgery at an academic center from 2005 to 2014.
Results: Fifty-seven patients (56%) were female with a mean age of 53 (± 11) years. The mean pre-operative BMI and glycated hemoglobin (HbA1c) were 43.1 (± 7.6) kg/m2 and 8.4 (± 1.8)%, respectively. The median pre-operative uACR was 80.0 (45.0-231.0) mg/g. Bariatric procedures included Roux-en-Y gastric bypass (n = 75, 74%) and sleeve gastrectomy (n = 26, 26%). The mean follow-up period was 61 (± 29) months. At last follow-up, the mean BMI was 33.8 (± 8.3) kg/m2. The overall glycemic control improved after bariatric surgery. At last follow-up, 73% had good glycemic control (HbA1c < 7%) and 27% met diabetes remission criteria. The mean HbA1c at last follow-up was 6.7 (± 1.0)% and the median uACR was 30 (IQR 7-94) mg/g. Albuminuria improved in 77% and resolved in 51% of patients at long-term.
Conclusions: Bariatric surgery has a significantly positive impact on albuminuria in patients with obesity and type 2 diabetes. Our data showed almost an 80% improvement in albuminuria at the short- and long-term period after bariatric surgery. |
| first_indexed | 2024-03-06T10:29:35Z |
| format | Article |
| id | upm.eprints-81246 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:29:35Z |
| publishDate | 2019 |
| publisher | Springer |
| record_format | dspace |
| spelling | upm.eprints-812462021-06-16T02:34:45Z http://psasir.upm.edu.my/id/eprint/81246/ Long-term impact of bariatric surgery in diabetic nephropathy Young, LeAnne Nor Hanipah, Zubaidah Brethauer, Stacy A. Schauer, Philip R. Aminian, Ali Background: Bariatric surgery has been shown to improve and resolve diabetes. However, limited literature about its impact on end-organ complications of diabetes is available. The aim of this study was to examine the long-term effect of bariatric surgery on albuminuria. Methods: We studied 101 patients with pre-operative diabetes and albuminuria [defined as urine albumin:creatinine ratio (uACR) > 30 mg/g] who underwent bariatric surgery at an academic center from 2005 to 2014. Results: Fifty-seven patients (56%) were female with a mean age of 53 (± 11) years. The mean pre-operative BMI and glycated hemoglobin (HbA1c) were 43.1 (± 7.6) kg/m2 and 8.4 (± 1.8)%, respectively. The median pre-operative uACR was 80.0 (45.0-231.0) mg/g. Bariatric procedures included Roux-en-Y gastric bypass (n = 75, 74%) and sleeve gastrectomy (n = 26, 26%). The mean follow-up period was 61 (± 29) months. At last follow-up, the mean BMI was 33.8 (± 8.3) kg/m2. The overall glycemic control improved after bariatric surgery. At last follow-up, 73% had good glycemic control (HbA1c < 7%) and 27% met diabetes remission criteria. The mean HbA1c at last follow-up was 6.7 (± 1.0)% and the median uACR was 30 (IQR 7-94) mg/g. Albuminuria improved in 77% and resolved in 51% of patients at long-term. Conclusions: Bariatric surgery has a significantly positive impact on albuminuria in patients with obesity and type 2 diabetes. Our data showed almost an 80% improvement in albuminuria at the short- and long-term period after bariatric surgery. Springer 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81246/1/BARIATIC.pdf Young, LeAnne and Nor Hanipah, Zubaidah and Brethauer, Stacy A. and Schauer, Philip R. and Aminian, Ali (2019) Long-term impact of bariatric surgery in diabetic nephropathy. Surgical Endoscopy and Other Interventional Techniques, 33 (5). pp. 1654-1660. ISSN 0930-2794 ; ESSN:1432-2218 https://pubmed.ncbi.nlm.nih.gov/30251143/ 10.1007/s00464-018-6458-8 |
| spellingShingle | Young, LeAnne Nor Hanipah, Zubaidah Brethauer, Stacy A. Schauer, Philip R. Aminian, Ali Long-term impact of bariatric surgery in diabetic nephropathy |
| title | Long-term impact of bariatric surgery in diabetic nephropathy |
| title_full | Long-term impact of bariatric surgery in diabetic nephropathy |
| title_fullStr | Long-term impact of bariatric surgery in diabetic nephropathy |
| title_full_unstemmed | Long-term impact of bariatric surgery in diabetic nephropathy |
| title_short | Long-term impact of bariatric surgery in diabetic nephropathy |
| title_sort | long term impact of bariatric surgery in diabetic nephropathy |
| url | http://psasir.upm.edu.my/id/eprint/81246/1/BARIATIC.pdf |
| work_keys_str_mv | AT youngleanne longtermimpactofbariatricsurgeryindiabeticnephropathy AT norhanipahzubaidah longtermimpactofbariatricsurgeryindiabeticnephropathy AT brethauerstacya longtermimpactofbariatricsurgeryindiabeticnephropathy AT schauerphilipr longtermimpactofbariatricsurgeryindiabeticnephropathy AT aminianali longtermimpactofbariatricsurgeryindiabeticnephropathy |