Mechanisms of oral bacterial virulence factors in pancreatic cancer
Pancreatic cancer is a highly lethal disease, and most patients remain asymptomatic until the disease enters advanced stages. There is lack of knowledge in the pathogenesis, effective prevention and early diagnosis of pancreatic cancer. Recently, bacteria were found in pancreatic tissue that has bee...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S. A.
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81325/1/Mechanisms%20of%20oral%20bacterial%20virulence%20factors%20in%20pancreatic%20cancer.pdf |
| _version_ | 1796980895737970688 |
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| author | Sun, Zhong Xiong, Cheng Long Teh, Seoh Wei Lim, Jonathan Chee Woei Kumar, Suresh Thilakavathy, Karuppiah |
| author_facet | Sun, Zhong Xiong, Cheng Long Teh, Seoh Wei Lim, Jonathan Chee Woei Kumar, Suresh Thilakavathy, Karuppiah |
| author_sort | Sun, Zhong |
| collection | UPM |
| description | Pancreatic cancer is a highly lethal disease, and most patients remain asymptomatic until the disease enters advanced stages. There is lack of knowledge in the pathogenesis, effective prevention and early diagnosis of pancreatic cancer. Recently, bacteria were found in pancreatic tissue that has been considered sterile before. The distribution of flora in pancreatic cancer tissue was reported to be different from normal pancreatic tissue. These abnormally distributed bacteria may be the risk factors for inducing pancreatic cancer. Therefore, studies on combined effect of multi-bacterial and multi-virulence factors may add to the knowledge of pancreatic cancer pathogenesis and aid in designing new preventive and therapeutic strategies. In this review, we outlined three oral bacteria associated with pancreatic cancer and their virulence factors linked with cancer. |
| first_indexed | 2024-03-06T10:29:46Z |
| format | Article |
| id | upm.eprints-81325 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:29:46Z |
| publishDate | 2019 |
| publisher | Frontiers Media S. A. |
| record_format | dspace |
| spelling | upm.eprints-813252021-02-23T18:25:46Z http://psasir.upm.edu.my/id/eprint/81325/ Mechanisms of oral bacterial virulence factors in pancreatic cancer Sun, Zhong Xiong, Cheng Long Teh, Seoh Wei Lim, Jonathan Chee Woei Kumar, Suresh Thilakavathy, Karuppiah Pancreatic cancer is a highly lethal disease, and most patients remain asymptomatic until the disease enters advanced stages. There is lack of knowledge in the pathogenesis, effective prevention and early diagnosis of pancreatic cancer. Recently, bacteria were found in pancreatic tissue that has been considered sterile before. The distribution of flora in pancreatic cancer tissue was reported to be different from normal pancreatic tissue. These abnormally distributed bacteria may be the risk factors for inducing pancreatic cancer. Therefore, studies on combined effect of multi-bacterial and multi-virulence factors may add to the knowledge of pancreatic cancer pathogenesis and aid in designing new preventive and therapeutic strategies. In this review, we outlined three oral bacteria associated with pancreatic cancer and their virulence factors linked with cancer. Frontiers Media S. A. 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81325/1/Mechanisms%20of%20oral%20bacterial%20virulence%20factors%20in%20pancreatic%20cancer.pdf Sun, Zhong and Xiong, Cheng Long and Teh, Seoh Wei and Lim, Jonathan Chee Woei and Kumar, Suresh and Thilakavathy, Karuppiah (2019) Mechanisms of oral bacterial virulence factors in pancreatic cancer. Frontiers in Cellular and Infection Microbiology, 9. art. no. 412. pp. 1-7. ISSN 2235-2988 https://www.frontiersin.org/articles/10.3389/fcimb.2019.00412/full 10.3389/fcimb.2019.00412 |
| spellingShingle | Sun, Zhong Xiong, Cheng Long Teh, Seoh Wei Lim, Jonathan Chee Woei Kumar, Suresh Thilakavathy, Karuppiah Mechanisms of oral bacterial virulence factors in pancreatic cancer |
| title | Mechanisms of oral bacterial virulence factors in pancreatic cancer |
| title_full | Mechanisms of oral bacterial virulence factors in pancreatic cancer |
| title_fullStr | Mechanisms of oral bacterial virulence factors in pancreatic cancer |
| title_full_unstemmed | Mechanisms of oral bacterial virulence factors in pancreatic cancer |
| title_short | Mechanisms of oral bacterial virulence factors in pancreatic cancer |
| title_sort | mechanisms of oral bacterial virulence factors in pancreatic cancer |
| url | http://psasir.upm.edu.my/id/eprint/81325/1/Mechanisms%20of%20oral%20bacterial%20virulence%20factors%20in%20pancreatic%20cancer.pdf |
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