Mechanistic understanding of curcumin’s therapeutic effects in lung cancer
Lung cancer is among the most common cancers with a high mortality rate worldwide. Despite the significant advances in diagnostic and therapeutic approaches, lung cancer prognoses and survival rates remain poor due to late diagnosis, drug resistance, and adverse effects. Therefore, new intervention...
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| Format: | Article |
| Language: | English |
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Multidisciplinary Digital Publishing Institute (MDPI)
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81326/1/Mechanistic%20understanding%20of%20curcumin%E2%80%99s%20therapeutic%20effects%20in%20lung%20cancer.pdf |
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| author | Wan Mohd Tajuddin, Wan Nur Baitty Lajis, Nordin H. Abas, Faridah Othman, Iekhsan Naidu, Rakesh |
| author_facet | Wan Mohd Tajuddin, Wan Nur Baitty Lajis, Nordin H. Abas, Faridah Othman, Iekhsan Naidu, Rakesh |
| author_sort | Wan Mohd Tajuddin, Wan Nur Baitty |
| collection | UPM |
| description | Lung cancer is among the most common cancers with a high mortality rate worldwide. Despite the significant advances in diagnostic and therapeutic approaches, lung cancer prognoses and survival rates remain poor due to late diagnosis, drug resistance, and adverse effects. Therefore, new intervention therapies, such as the use of natural compounds with decreased toxicities, have been considered in lung cancer therapy. Curcumin, a natural occurring polyphenol derived from turmeric (Curcuma longa) has been studied extensively in recent years for its therapeutic effects. It has been shown that curcumin demonstrates anti-cancer effects in lung cancer through various mechanisms, including inhibition of cell proliferation, invasion, and metastasis, induction of apoptosis, epigenetic alterations, and regulation of microRNA expression. Several in vitro and in vivo studies have shown that these mechanisms are modulated by multiple molecular targets such as STAT3, EGFR, FOXO3a, TGF-β, eIF2α, COX-2, Bcl-2, PI3KAkt/mTOR, ROS, Fas/FasL, Cdc42, E-cadherin, MMPs, and adiponectin. In addition, limitations, strategies to overcome curcumin bioavailability, and potential side effects as well as clinical trials were also reviewed. |
| first_indexed | 2024-03-06T10:29:47Z |
| format | Article |
| id | upm.eprints-81326 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:29:47Z |
| publishDate | 2019 |
| publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
| record_format | dspace |
| spelling | upm.eprints-813262021-02-23T18:16:40Z http://psasir.upm.edu.my/id/eprint/81326/ Mechanistic understanding of curcumin’s therapeutic effects in lung cancer Wan Mohd Tajuddin, Wan Nur Baitty Lajis, Nordin H. Abas, Faridah Othman, Iekhsan Naidu, Rakesh Lung cancer is among the most common cancers with a high mortality rate worldwide. Despite the significant advances in diagnostic and therapeutic approaches, lung cancer prognoses and survival rates remain poor due to late diagnosis, drug resistance, and adverse effects. Therefore, new intervention therapies, such as the use of natural compounds with decreased toxicities, have been considered in lung cancer therapy. Curcumin, a natural occurring polyphenol derived from turmeric (Curcuma longa) has been studied extensively in recent years for its therapeutic effects. It has been shown that curcumin demonstrates anti-cancer effects in lung cancer through various mechanisms, including inhibition of cell proliferation, invasion, and metastasis, induction of apoptosis, epigenetic alterations, and regulation of microRNA expression. Several in vitro and in vivo studies have shown that these mechanisms are modulated by multiple molecular targets such as STAT3, EGFR, FOXO3a, TGF-β, eIF2α, COX-2, Bcl-2, PI3KAkt/mTOR, ROS, Fas/FasL, Cdc42, E-cadherin, MMPs, and adiponectin. In addition, limitations, strategies to overcome curcumin bioavailability, and potential side effects as well as clinical trials were also reviewed. Multidisciplinary Digital Publishing Institute (MDPI) 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81326/1/Mechanistic%20understanding%20of%20curcumin%E2%80%99s%20therapeutic%20effects%20in%20lung%20cancer.pdf Wan Mohd Tajuddin, Wan Nur Baitty and Lajis, Nordin H. and Abas, Faridah and Othman, Iekhsan and Naidu, Rakesh (2019) Mechanistic understanding of curcumin’s therapeutic effects in lung cancer. Nutrients, 11 (12). art. no. 2989. pp. 1-29. ISSN 2072-6643 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950067/ 10.3390/nu11122989 |
| spellingShingle | Wan Mohd Tajuddin, Wan Nur Baitty Lajis, Nordin H. Abas, Faridah Othman, Iekhsan Naidu, Rakesh Mechanistic understanding of curcumin’s therapeutic effects in lung cancer |
| title | Mechanistic understanding of curcumin’s therapeutic effects in lung cancer |
| title_full | Mechanistic understanding of curcumin’s therapeutic effects in lung cancer |
| title_fullStr | Mechanistic understanding of curcumin’s therapeutic effects in lung cancer |
| title_full_unstemmed | Mechanistic understanding of curcumin’s therapeutic effects in lung cancer |
| title_short | Mechanistic understanding of curcumin’s therapeutic effects in lung cancer |
| title_sort | mechanistic understanding of curcumin s therapeutic effects in lung cancer |
| url | http://psasir.upm.edu.my/id/eprint/81326/1/Mechanistic%20understanding%20of%20curcumin%E2%80%99s%20therapeutic%20effects%20in%20lung%20cancer.pdf |
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