Optimization of synthesis parameters of mesoporous silica nanoparticles based on ionic liquid by experimental design and its application as drug delivery agent
Optimization is a process utilized to discover the best condition to generate the best possible outcome. One of the common optimization method used in the field of chemistry is response surface methodology (RSM). This method consists of mathematical and statistical techniques which relate the respon...
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| Format: | Article |
| Language: | English |
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Hindawi
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81576/1/Optimization%20of%20synthesis%20parameters%20of%20mesoporous%20silica%20nanoparticles.pdf |
| _version_ | 1825951463359119360 |
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| author | Mohamed Isa, Eleen Dayana Ahmad, Haslina Abdul Rahman, Mohd Basyaruddin |
| author_facet | Mohamed Isa, Eleen Dayana Ahmad, Haslina Abdul Rahman, Mohd Basyaruddin |
| author_sort | Mohamed Isa, Eleen Dayana |
| collection | UPM |
| description | Optimization is a process utilized to discover the best condition to generate the best possible outcome. One of the common optimization method used in the field of chemistry is response surface methodology (RSM). This method consists of mathematical and statistical techniques which relate the responses with the variables of interest. There are many experimental designs in RSM, and one of the most common one is the Box-Behnken design (BBD). In this work, BBD was employed to analyze the main effects and interactions of the reaction temperature, amount of template, and amount of triethanolamine (TEA) on the two responses which are the surface area (SA) and particle size (PS) of ionic liquid templated mesoporous silica nanoparticles (MSNs). It was found that the SA and PS were fitted with linear and quadratic models, respectively. MSNs with the highest surface area (999.051 m2 g-1) was chosen for the application of drug delivery; thus, drug loading and drug release experiments were conducted. From these studies, it was found that 37% of drug (quercetin) was successfully encapsulated in MSN and, in 48 hours, 32% of the drug was released. |
| first_indexed | 2024-03-06T10:30:24Z |
| format | Article |
| id | upm.eprints-81576 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:30:24Z |
| publishDate | 2019 |
| publisher | Hindawi |
| record_format | dspace |
| spelling | upm.eprints-815762022-01-13T07:26:14Z http://psasir.upm.edu.my/id/eprint/81576/ Optimization of synthesis parameters of mesoporous silica nanoparticles based on ionic liquid by experimental design and its application as drug delivery agent Mohamed Isa, Eleen Dayana Ahmad, Haslina Abdul Rahman, Mohd Basyaruddin Optimization is a process utilized to discover the best condition to generate the best possible outcome. One of the common optimization method used in the field of chemistry is response surface methodology (RSM). This method consists of mathematical and statistical techniques which relate the responses with the variables of interest. There are many experimental designs in RSM, and one of the most common one is the Box-Behnken design (BBD). In this work, BBD was employed to analyze the main effects and interactions of the reaction temperature, amount of template, and amount of triethanolamine (TEA) on the two responses which are the surface area (SA) and particle size (PS) of ionic liquid templated mesoporous silica nanoparticles (MSNs). It was found that the SA and PS were fitted with linear and quadratic models, respectively. MSNs with the highest surface area (999.051 m2 g-1) was chosen for the application of drug delivery; thus, drug loading and drug release experiments were conducted. From these studies, it was found that 37% of drug (quercetin) was successfully encapsulated in MSN and, in 48 hours, 32% of the drug was released. Hindawi 2019-03-24 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81576/1/Optimization%20of%20synthesis%20parameters%20of%20mesoporous%20silica%20nanoparticles.pdf Mohamed Isa, Eleen Dayana and Ahmad, Haslina and Abdul Rahman, Mohd Basyaruddin (2019) Optimization of synthesis parameters of mesoporous silica nanoparticles based on ionic liquid by experimental design and its application as drug delivery agent. Journal of Nanomaterials, 2019. art. no. 4982054. pp. 1-9. ISSN 1687-4110; ESSN:1687-4129 https://www.hindawi.com/journals/jnm/2019/4982054/ 10.1155/2019/4982054 |
| spellingShingle | Mohamed Isa, Eleen Dayana Ahmad, Haslina Abdul Rahman, Mohd Basyaruddin Optimization of synthesis parameters of mesoporous silica nanoparticles based on ionic liquid by experimental design and its application as drug delivery agent |
| title | Optimization of synthesis parameters of mesoporous silica nanoparticles based on ionic liquid by experimental design and its application as drug delivery agent |
| title_full | Optimization of synthesis parameters of mesoporous silica nanoparticles based on ionic liquid by experimental design and its application as drug delivery agent |
| title_fullStr | Optimization of synthesis parameters of mesoporous silica nanoparticles based on ionic liquid by experimental design and its application as drug delivery agent |
| title_full_unstemmed | Optimization of synthesis parameters of mesoporous silica nanoparticles based on ionic liquid by experimental design and its application as drug delivery agent |
| title_short | Optimization of synthesis parameters of mesoporous silica nanoparticles based on ionic liquid by experimental design and its application as drug delivery agent |
| title_sort | optimization of synthesis parameters of mesoporous silica nanoparticles based on ionic liquid by experimental design and its application as drug delivery agent |
| url | http://psasir.upm.edu.my/id/eprint/81576/1/Optimization%20of%20synthesis%20parameters%20of%20mesoporous%20silica%20nanoparticles.pdf |
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