Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics
Curcuma species is a popular traditional folk medicine in India and Southeast Asia. This study aims to profile the metabolites in four Curcuma species, including C. zedoaria, C. xanthorrhiza, C. aeruginosa and C. mangga at three developmental stages (seven, eight and nine months old) using nuclear...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Academic Press
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81737/1/Phytochemical%20and%20bioactivity%20alterations.pdf |
| _version_ | 1825951483154137088 |
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| author | Awin, Tahani M. Mediani, Ahmed Maulidiani Leong, Sze Wei Mohd Faudzi, Siti Munirah Shaari, Khozirah Abas, Faridah |
| author_facet | Awin, Tahani M. Mediani, Ahmed Maulidiani Leong, Sze Wei Mohd Faudzi, Siti Munirah Shaari, Khozirah Abas, Faridah |
| author_sort | Awin, Tahani M. |
| collection | UPM |
| description | Curcuma species is a popular traditional folk medicine in India and Southeast Asia. This study aims to profile the
metabolites in four Curcuma species, including C. zedoaria, C. xanthorrhiza, C. aeruginosa and C. mangga at three
developmental stages (seven, eight and nine months old) using nuclear magnetic resonance (NMR)-based metabolomics. Principal component analysis (PCA) showed that there are metabolites changes due to the month of
harvest in each of the four species. A large quantity of curcumin and demethoxycurcumin contributed to the
separation of C. xanthorrhiza, whereas the diterpenoids, such as curcumanggoside, (E)-labda-8(17),12-diene15,16-dial, calcaratarin A and zerumin B were responsible for the discrimination of C. mangga. Eight-month-old
C. xanthorrhiza exhibited the highest nitric oxide (NO) inhibitory activity, while nine-month-old C. mangga
exhibited the highest α-glucosidase inhibitory activity. The correlation among the bioactivities and phytochemical constituents was determined using partial least square (PLS) analysis. Curcumin, demethoxycurcumin,
germacrone, zedoarol and xanthorrhizol were correlated with the NO inhibitory activity in C. xanthorrhiza,
whereas curcumanggoside, labda-8(17),12-diene-15,16-dial and zerumin B were correlated with the α-glucosidase inhibitory activity in C. mangga. From the phytochemical markers and metabolic changes among growth
stages of C. xanthorrhiza and C. mangga, the biosynthetic pathway was proposed to show the metabolites that
might contribute to their health benefits. |
| first_indexed | 2024-03-06T10:30:39Z |
| format | Article |
| id | upm.eprints-81737 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:30:39Z |
| publishDate | 2019 |
| publisher | Academic Press |
| record_format | dspace |
| spelling | upm.eprints-817372022-12-13T08:17:38Z http://psasir.upm.edu.my/id/eprint/81737/ Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics Awin, Tahani M. Mediani, Ahmed Maulidiani Leong, Sze Wei Mohd Faudzi, Siti Munirah Shaari, Khozirah Abas, Faridah Curcuma species is a popular traditional folk medicine in India and Southeast Asia. This study aims to profile the metabolites in four Curcuma species, including C. zedoaria, C. xanthorrhiza, C. aeruginosa and C. mangga at three developmental stages (seven, eight and nine months old) using nuclear magnetic resonance (NMR)-based metabolomics. Principal component analysis (PCA) showed that there are metabolites changes due to the month of harvest in each of the four species. A large quantity of curcumin and demethoxycurcumin contributed to the separation of C. xanthorrhiza, whereas the diterpenoids, such as curcumanggoside, (E)-labda-8(17),12-diene15,16-dial, calcaratarin A and zerumin B were responsible for the discrimination of C. mangga. Eight-month-old C. xanthorrhiza exhibited the highest nitric oxide (NO) inhibitory activity, while nine-month-old C. mangga exhibited the highest α-glucosidase inhibitory activity. The correlation among the bioactivities and phytochemical constituents was determined using partial least square (PLS) analysis. Curcumin, demethoxycurcumin, germacrone, zedoarol and xanthorrhizol were correlated with the NO inhibitory activity in C. xanthorrhiza, whereas curcumanggoside, labda-8(17),12-diene-15,16-dial and zerumin B were correlated with the α-glucosidase inhibitory activity in C. mangga. From the phytochemical markers and metabolic changes among growth stages of C. xanthorrhiza and C. mangga, the biosynthetic pathway was proposed to show the metabolites that might contribute to their health benefits. Academic Press 2019-04 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81737/1/Phytochemical%20and%20bioactivity%20alterations.pdf Awin, Tahani M. and Mediani, Ahmed and Maulidiani and Leong, Sze Wei and Mohd Faudzi, Siti Munirah and Shaari, Khozirah and Abas, Faridah (2019) Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics. Journal of Food Composition and Analysis, 77 (April 2019). pp. 66-76. ISSN 0889-1575; ESSN: 1096-0481 https://www.sciencedirect.com/science/article/pii/S0889157519300389 10.1016/j.jfca.2019.01.004 |
| spellingShingle | Awin, Tahani M. Mediani, Ahmed Maulidiani Leong, Sze Wei Mohd Faudzi, Siti Munirah Shaari, Khozirah Abas, Faridah Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics |
| title | Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics |
| title_full | Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics |
| title_fullStr | Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics |
| title_full_unstemmed | Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics |
| title_short | Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics |
| title_sort | phytochemical and bioactivity alterations of curcuma species harvested at different growth stages by nmr based metabolomics |
| url | http://psasir.upm.edu.my/id/eprint/81737/1/Phytochemical%20and%20bioactivity%20alterations.pdf |
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