Respiratory health among office workers in Malaysia and endotoxin and (1,3)-b-glucan in office dust
Objective: To examine the associations between endotoxin and (1,3)-β-glucan concentrations in office dust and respiratory symptoms and airway inflammation among 695 office workers in Malaysia. Methods: Health data were collected using a questionnaire, sensitisation testing and measurement of fractio...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
International Union Against Tuberculosis and Lung Disease
2019
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/82001/1/Respiratory%20health%20among%20office%20workers%20in%20Malaysia%20and%20endotoxin%20and%20%281%2C3%29-%20%CE%B2%20-glucan%20in%20office%20dust.pdf |
| _version_ | 1796980987353104384 |
|---|---|
| author | Lim, Fang Lee Hashim, Zailina Thian, Leslie Lung Than Md Said, Salmiah Hashim, Jamal Norbäck, Dan |
| author_facet | Lim, Fang Lee Hashim, Zailina Thian, Leslie Lung Than Md Said, Salmiah Hashim, Jamal Norbäck, Dan |
| author_sort | Lim, Fang Lee |
| collection | UPM |
| description | Objective: To examine the associations between endotoxin and (1,3)-β-glucan concentrations in office dust and respiratory symptoms and airway inflammation among 695 office workers in Malaysia. Methods: Health data were collected using a questionnaire, sensitisation testing and measurement of fractional exhaled nitric oxide (FeNO). Indoor temperature, relative air humidity (RH) and carbon dioxide (CO 2) were measured in the offices and settled dust was vacuumed and analysed for endotoxin and (1,3)-β-glucan concentrations. Associations were analysed by two level multiple logistic regression. Results: Overall, 9.6% of the workers had doctor-diagnosed asthma, 15.5% had wheeze, 18.4% had daytime attacks of breathlessness and 25.8% had elevated FeNO (≥25 ppb). The median levels in office dust were 11.3 EU/mg endotoxin and 62.9 ng/g (1,3)-β-glucan. After adjusting for personal and home environment factors, endotoxin concentration in dust was associated with wheeze (P = 0.02) and rhino conjunctivitis (P = 0.007). The amount of surface dust (P = 0.04) and (1,3)-β-glucan concentration dust (P = 0.03) were associated with elevated FeNO. Conclusion: Endotoxin in office dust could be a risk factor for wheeze and rhino conjunctivitis among office workers in mechanically ventilated offices in a tropical country. The amount of dust and (1,3)-β-glucan (a marker of indoor mould exposure) were associated with Th2 driven airway inflammation. |
| first_indexed | 2024-03-06T10:31:07Z |
| format | Article |
| id | upm.eprints-82001 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:31:07Z |
| publishDate | 2019 |
| publisher | International Union Against Tuberculosis and Lung Disease |
| record_format | dspace |
| spelling | upm.eprints-820012021-08-13T09:48:34Z http://psasir.upm.edu.my/id/eprint/82001/ Respiratory health among office workers in Malaysia and endotoxin and (1,3)-b-glucan in office dust Lim, Fang Lee Hashim, Zailina Thian, Leslie Lung Than Md Said, Salmiah Hashim, Jamal Norbäck, Dan Objective: To examine the associations between endotoxin and (1,3)-β-glucan concentrations in office dust and respiratory symptoms and airway inflammation among 695 office workers in Malaysia. Methods: Health data were collected using a questionnaire, sensitisation testing and measurement of fractional exhaled nitric oxide (FeNO). Indoor temperature, relative air humidity (RH) and carbon dioxide (CO 2) were measured in the offices and settled dust was vacuumed and analysed for endotoxin and (1,3)-β-glucan concentrations. Associations were analysed by two level multiple logistic regression. Results: Overall, 9.6% of the workers had doctor-diagnosed asthma, 15.5% had wheeze, 18.4% had daytime attacks of breathlessness and 25.8% had elevated FeNO (≥25 ppb). The median levels in office dust were 11.3 EU/mg endotoxin and 62.9 ng/g (1,3)-β-glucan. After adjusting for personal and home environment factors, endotoxin concentration in dust was associated with wheeze (P = 0.02) and rhino conjunctivitis (P = 0.007). The amount of surface dust (P = 0.04) and (1,3)-β-glucan concentration dust (P = 0.03) were associated with elevated FeNO. Conclusion: Endotoxin in office dust could be a risk factor for wheeze and rhino conjunctivitis among office workers in mechanically ventilated offices in a tropical country. The amount of dust and (1,3)-β-glucan (a marker of indoor mould exposure) were associated with Th2 driven airway inflammation. International Union Against Tuberculosis and Lung Disease 2019-11 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/82001/1/Respiratory%20health%20among%20office%20workers%20in%20Malaysia%20and%20endotoxin%20and%20%281%2C3%29-%20%CE%B2%20-glucan%20in%20office%20dust.pdf Lim, Fang Lee and Hashim, Zailina and Thian, Leslie Lung Than and Md Said, Salmiah and Hashim, Jamal and Norbäck, Dan (2019) Respiratory health among office workers in Malaysia and endotoxin and (1,3)-b-glucan in office dust. International Journal of Tuberculosis and Lung Disease, 23 (11). pp. 1171-1177. ISSN 1027-3719; ESSN: 1815-7920 https://pubmed.ncbi.nlm.nih.gov/31718753/ 10.5588/ijtld.18.0668 |
| spellingShingle | Lim, Fang Lee Hashim, Zailina Thian, Leslie Lung Than Md Said, Salmiah Hashim, Jamal Norbäck, Dan Respiratory health among office workers in Malaysia and endotoxin and (1,3)-b-glucan in office dust |
| title | Respiratory health among office workers in Malaysia and endotoxin and (1,3)-b-glucan in office dust |
| title_full | Respiratory health among office workers in Malaysia and endotoxin and (1,3)-b-glucan in office dust |
| title_fullStr | Respiratory health among office workers in Malaysia and endotoxin and (1,3)-b-glucan in office dust |
| title_full_unstemmed | Respiratory health among office workers in Malaysia and endotoxin and (1,3)-b-glucan in office dust |
| title_short | Respiratory health among office workers in Malaysia and endotoxin and (1,3)-b-glucan in office dust |
| title_sort | respiratory health among office workers in malaysia and endotoxin and 1 3 b glucan in office dust |
| url | http://psasir.upm.edu.my/id/eprint/82001/1/Respiratory%20health%20among%20office%20workers%20in%20Malaysia%20and%20endotoxin%20and%20%281%2C3%29-%20%CE%B2%20-glucan%20in%20office%20dust.pdf |
| work_keys_str_mv | AT limfanglee respiratoryhealthamongofficeworkersinmalaysiaandendotoxinand13bglucaninofficedust AT hashimzailina respiratoryhealthamongofficeworkersinmalaysiaandendotoxinand13bglucaninofficedust AT thianleslielungthan respiratoryhealthamongofficeworkersinmalaysiaandendotoxinand13bglucaninofficedust AT mdsaidsalmiah respiratoryhealthamongofficeworkersinmalaysiaandendotoxinand13bglucaninofficedust AT hashimjamal respiratoryhealthamongofficeworkersinmalaysiaandendotoxinand13bglucaninofficedust AT norbackdan respiratoryhealthamongofficeworkersinmalaysiaandendotoxinand13bglucaninofficedust |