Synthesis and characterisation of chitosan nanoparticle as a potential delivery carrier
Chitosan is a biodegradable, non-toxic polysaccharide that is extensively studied as a biocompatible vector for gene and drug delivery. However, the fabrication of chitosan nanoparticle (CNP) is usually encountered with a wide size distribution and poor particle stability, which unfortunately limits...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Malaysian Society for Molecular Biology and Biotechnology, Universiti Putra Malaysia
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/82331/1/Synthesis%20and%20characterisation%20of%20chitosan%20nanoparticle%20as%20a%20potential%20delivery%20carrier%20.pdf |
| _version_ | 1825951553684504576 |
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| author | Ibrahim, Noor Hidayah Masarudin, Mas Jaffri Omar, Abdul Rahman Bejo, Mohd Hair Abdul Rahim, Raha Mat Isa, Nurulfiza |
| author_facet | Ibrahim, Noor Hidayah Masarudin, Mas Jaffri Omar, Abdul Rahman Bejo, Mohd Hair Abdul Rahim, Raha Mat Isa, Nurulfiza |
| author_sort | Ibrahim, Noor Hidayah |
| collection | UPM |
| description | Chitosan is a biodegradable, non-toxic polysaccharide that is extensively studied as a biocompatible vector for gene and drug delivery. However, the fabrication of chitosan nanoparticle (CNP) is usually encountered with a wide size distribution and poor particle stability, which unfortunately limits their role for certain biological applications. This study reports the synthesis and characterisation of CNPs under optimised conditions. The CNPs were synthesised via ionic gelation process utilizing tripolyphosphate (TPP) as a cross-linking agent. The particle size and morphology of samples were subsequently evaluated using dynamic light scattering (DLS), electron microscopy and Fourier-transform infrared spectroscopy (FTIR). Findings arising from this study showed the optimised nanoparticles exhibited spherical shaped CNPs with a size range from 4 to 25nm which lays the foundation for further applications. |
| first_indexed | 2024-03-06T10:31:44Z |
| format | Article |
| id | upm.eprints-82331 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:31:44Z |
| publishDate | 2019 |
| publisher | Malaysian Society for Molecular Biology and Biotechnology, Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-823312021-08-11T06:19:37Z http://psasir.upm.edu.my/id/eprint/82331/ Synthesis and characterisation of chitosan nanoparticle as a potential delivery carrier Ibrahim, Noor Hidayah Masarudin, Mas Jaffri Omar, Abdul Rahman Bejo, Mohd Hair Abdul Rahim, Raha Mat Isa, Nurulfiza Chitosan is a biodegradable, non-toxic polysaccharide that is extensively studied as a biocompatible vector for gene and drug delivery. However, the fabrication of chitosan nanoparticle (CNP) is usually encountered with a wide size distribution and poor particle stability, which unfortunately limits their role for certain biological applications. This study reports the synthesis and characterisation of CNPs under optimised conditions. The CNPs were synthesised via ionic gelation process utilizing tripolyphosphate (TPP) as a cross-linking agent. The particle size and morphology of samples were subsequently evaluated using dynamic light scattering (DLS), electron microscopy and Fourier-transform infrared spectroscopy (FTIR). Findings arising from this study showed the optimised nanoparticles exhibited spherical shaped CNPs with a size range from 4 to 25nm which lays the foundation for further applications. Malaysian Society for Molecular Biology and Biotechnology, Universiti Putra Malaysia 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/82331/1/Synthesis%20and%20characterisation%20of%20chitosan%20nanoparticle%20as%20a%20potential%20delivery%20carrier%20.pdf Ibrahim, Noor Hidayah and Masarudin, Mas Jaffri and Omar, Abdul Rahman and Bejo, Mohd Hair and Abdul Rahim, Raha and Mat Isa, Nurulfiza (2019) Synthesis and characterisation of chitosan nanoparticle as a potential delivery carrier. Asia-Pacific Journal of Molecular Biology and Biotechnology, 27 (4). pp. 80-84. ISSN 0128-7451; ESSN: 2672-7277 http://www.msmbb.my/index.php/volume-27-2019 10.35118/apjmbb.2019.027.4.09 |
| spellingShingle | Ibrahim, Noor Hidayah Masarudin, Mas Jaffri Omar, Abdul Rahman Bejo, Mohd Hair Abdul Rahim, Raha Mat Isa, Nurulfiza Synthesis and characterisation of chitosan nanoparticle as a potential delivery carrier |
| title | Synthesis and characterisation of chitosan nanoparticle as a potential delivery carrier |
| title_full | Synthesis and characterisation of chitosan nanoparticle as a potential delivery carrier |
| title_fullStr | Synthesis and characterisation of chitosan nanoparticle as a potential delivery carrier |
| title_full_unstemmed | Synthesis and characterisation of chitosan nanoparticle as a potential delivery carrier |
| title_short | Synthesis and characterisation of chitosan nanoparticle as a potential delivery carrier |
| title_sort | synthesis and characterisation of chitosan nanoparticle as a potential delivery carrier |
| url | http://psasir.upm.edu.my/id/eprint/82331/1/Synthesis%20and%20characterisation%20of%20chitosan%20nanoparticle%20as%20a%20potential%20delivery%20carrier%20.pdf |
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