Tumour-associated macrophages (TAMs) in colon cancer and how to reeducate them
Tumour-associated macrophage (TAM) serves as the site in which most inflammatory cells coreside. It plays an important role in determining the progression and metastasis of a tumour. The characteristic of TAM is largely dependent on the stimuli present in its tumour microenvironment (TME). Under thi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/82446/1/Tumour-associated%20macrophages%202.pdf |
| _version_ | 1825951563695259648 |
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| author | Yahaya, Muhamad Afiq Faisal Mohd Lila, Mohd Azmi Ismail, Saila Zainol, Muhammad Faisal Nik Abd. Rahman, Nik Mohd Afizan |
| author_facet | Yahaya, Muhamad Afiq Faisal Mohd Lila, Mohd Azmi Ismail, Saila Zainol, Muhammad Faisal Nik Abd. Rahman, Nik Mohd Afizan |
| author_sort | Yahaya, Muhamad Afiq Faisal |
| collection | UPM |
| description | Tumour-associated macrophage (TAM) serves as the site in which most inflammatory cells coreside. It plays an important role in determining the progression and metastasis of a tumour. The characteristic of TAM is largely dependent on the stimuli present in its tumour microenvironment (TME). Under this environment, however, M2 macrophages are found to be in abundance compared to M1 macrophages which later promote tumour progression. Numerous studies have elucidated the relationship between TAM and the progression of tumour; hence, TAM has now been the subject of interest among researchers for anticancer therapy. This review discusses the role of TAM in colorectal cancer (CRC) and some of the potential candidates that could reeducate TAM to fight against CRC. It is with hope that this review will serve as the foundation in understanding TAM in CRC and helping other researchers to select the most suitable candidate to reeducate TAM that could assist in enhancing the tumouricidal activity of M1 macrophage and eventually repress the development of CRC. |
| first_indexed | 2024-03-06T10:31:53Z |
| format | Article |
| id | upm.eprints-82446 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:31:53Z |
| publishDate | 2019 |
| publisher | Hindawi |
| record_format | dspace |
| spelling | upm.eprints-824462021-09-29T06:20:36Z http://psasir.upm.edu.my/id/eprint/82446/ Tumour-associated macrophages (TAMs) in colon cancer and how to reeducate them Yahaya, Muhamad Afiq Faisal Mohd Lila, Mohd Azmi Ismail, Saila Zainol, Muhammad Faisal Nik Abd. Rahman, Nik Mohd Afizan Tumour-associated macrophage (TAM) serves as the site in which most inflammatory cells coreside. It plays an important role in determining the progression and metastasis of a tumour. The characteristic of TAM is largely dependent on the stimuli present in its tumour microenvironment (TME). Under this environment, however, M2 macrophages are found to be in abundance compared to M1 macrophages which later promote tumour progression. Numerous studies have elucidated the relationship between TAM and the progression of tumour; hence, TAM has now been the subject of interest among researchers for anticancer therapy. This review discusses the role of TAM in colorectal cancer (CRC) and some of the potential candidates that could reeducate TAM to fight against CRC. It is with hope that this review will serve as the foundation in understanding TAM in CRC and helping other researchers to select the most suitable candidate to reeducate TAM that could assist in enhancing the tumouricidal activity of M1 macrophage and eventually repress the development of CRC. Hindawi 2019-02 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/82446/1/Tumour-associated%20macrophages%202.pdf Yahaya, Muhamad Afiq Faisal and Mohd Lila, Mohd Azmi and Ismail, Saila and Zainol, Muhammad Faisal and Nik Abd. Rahman, Nik Mohd Afizan (2019) Tumour-associated macrophages (TAMs) in colon cancer and how to reeducate them. Journal of Immunology Research, 2019. art. no. 2368249. pp. 1-9. ISSN 2314-8861; ESSN: 2314-7156 https://www.hindawi.com/journals/jir/2019/2368249/ 10.1155/2019/2368249 |
| spellingShingle | Yahaya, Muhamad Afiq Faisal Mohd Lila, Mohd Azmi Ismail, Saila Zainol, Muhammad Faisal Nik Abd. Rahman, Nik Mohd Afizan Tumour-associated macrophages (TAMs) in colon cancer and how to reeducate them |
| title | Tumour-associated macrophages (TAMs) in colon cancer and how to reeducate them |
| title_full | Tumour-associated macrophages (TAMs) in colon cancer and how to reeducate them |
| title_fullStr | Tumour-associated macrophages (TAMs) in colon cancer and how to reeducate them |
| title_full_unstemmed | Tumour-associated macrophages (TAMs) in colon cancer and how to reeducate them |
| title_short | Tumour-associated macrophages (TAMs) in colon cancer and how to reeducate them |
| title_sort | tumour associated macrophages tams in colon cancer and how to reeducate them |
| url | http://psasir.upm.edu.my/id/eprint/82446/1/Tumour-associated%20macrophages%202.pdf |
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