Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study
Allergic diseases are the most common chronic illness in childhood. Findings from developed countries have reported associations between Vitamin D levels during pregnancy and offspring allergy risk. This prospective cohort study aimed to determine the associations between maternal Vitamin D levels d...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Multidisciplinary Digital Publishing Institute
2020
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/86655/1/Maternal%20Vitamin%20D%20.pdf |
| _version_ | 1796981734075531264 |
|---|---|
| author | Woon, Fui Chee Chin, Yit Siew Ismail, Intan Hakimah Abdul Latiff, Amir Hamzah Batterham, Marijka Chan, Yoke Mun |
| author_facet | Woon, Fui Chee Chin, Yit Siew Ismail, Intan Hakimah Abdul Latiff, Amir Hamzah Batterham, Marijka Chan, Yoke Mun |
| author_sort | Woon, Fui Chee |
| collection | UPM |
| description | Allergic diseases are the most common chronic illness in childhood. Findings from developed countries have reported associations between Vitamin D levels during pregnancy and offspring allergy risk. This prospective cohort study aimed to determine the associations between maternal Vitamin D levels during late pregnancy and allergic diseases in Malaysian infants during the first year of life. Serum 25(OH)D concentrations of 380 pregnant women in the third trimester were measured using a chemiluminescent immunoassay. Children’s allergic outcomes were assessed at 3, 6, and 12 months based on parental reports. Specific IgE antibodies against food and inhalant allergens were measured in infants at 12 months of age. A total of 43.2% pregnant women were Vitamin D deficient (<30 nmol/L) and 56.8% were nondeficient (≥30 nmol/L). A total of 27.6% of the infants had eczema, 6.1% had wheeze, 27.4% had food sensitization, 10.8% had inhalant allergen sensitization, and 3.8% had IgE-mediated food allergy during the first year of life. Compared with the nondeficient group, maternal Vitamin D deficiency in late pregnancy was not associated with any allergic outcomes after adjustment for potential confounding factors. In conclusion, the present study does not support an association between maternal Vitamin D levels in late pregnancy and allergic outcomes during the first year of life. |
| first_indexed | 2024-03-06T10:41:59Z |
| format | Article |
| id | upm.eprints-86655 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:41:59Z |
| publishDate | 2020 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-866552021-11-05T02:13:58Z http://psasir.upm.edu.my/id/eprint/86655/ Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study Woon, Fui Chee Chin, Yit Siew Ismail, Intan Hakimah Abdul Latiff, Amir Hamzah Batterham, Marijka Chan, Yoke Mun Allergic diseases are the most common chronic illness in childhood. Findings from developed countries have reported associations between Vitamin D levels during pregnancy and offspring allergy risk. This prospective cohort study aimed to determine the associations between maternal Vitamin D levels during late pregnancy and allergic diseases in Malaysian infants during the first year of life. Serum 25(OH)D concentrations of 380 pregnant women in the third trimester were measured using a chemiluminescent immunoassay. Children’s allergic outcomes were assessed at 3, 6, and 12 months based on parental reports. Specific IgE antibodies against food and inhalant allergens were measured in infants at 12 months of age. A total of 43.2% pregnant women were Vitamin D deficient (<30 nmol/L) and 56.8% were nondeficient (≥30 nmol/L). A total of 27.6% of the infants had eczema, 6.1% had wheeze, 27.4% had food sensitization, 10.8% had inhalant allergen sensitization, and 3.8% had IgE-mediated food allergy during the first year of life. Compared with the nondeficient group, maternal Vitamin D deficiency in late pregnancy was not associated with any allergic outcomes after adjustment for potential confounding factors. In conclusion, the present study does not support an association between maternal Vitamin D levels in late pregnancy and allergic outcomes during the first year of life. Multidisciplinary Digital Publishing Institute 2020-08-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86655/1/Maternal%20Vitamin%20D%20.pdf Woon, Fui Chee and Chin, Yit Siew and Ismail, Intan Hakimah and Abdul Latiff, Amir Hamzah and Batterham, Marijka and Chan, Yoke Mun (2020) Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study. Nutrients, 12 (8). art. no. 2418. pp. 1-12. ISSN 2072-6643 https://www.mdpi.com/2072-6643/12/8/2418 10.3390/nu12082418 |
| spellingShingle | Woon, Fui Chee Chin, Yit Siew Ismail, Intan Hakimah Abdul Latiff, Amir Hamzah Batterham, Marijka Chan, Yoke Mun Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study |
| title | Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study |
| title_full | Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study |
| title_fullStr | Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study |
| title_full_unstemmed | Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study |
| title_short | Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study |
| title_sort | maternal vitamin d levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life a birth cohort study |
| url | http://psasir.upm.edu.my/id/eprint/86655/1/Maternal%20Vitamin%20D%20.pdf |
| work_keys_str_mv | AT woonfuichee maternalvitamindlevelsduringlatepregnancyandriskofallergicdiseasesandsensitizationduringthefirstyearoflifeabirthcohortstudy AT chinyitsiew maternalvitamindlevelsduringlatepregnancyandriskofallergicdiseasesandsensitizationduringthefirstyearoflifeabirthcohortstudy AT ismailintanhakimah maternalvitamindlevelsduringlatepregnancyandriskofallergicdiseasesandsensitizationduringthefirstyearoflifeabirthcohortstudy AT abdullatiffamirhamzah maternalvitamindlevelsduringlatepregnancyandriskofallergicdiseasesandsensitizationduringthefirstyearoflifeabirthcohortstudy AT batterhammarijka maternalvitamindlevelsduringlatepregnancyandriskofallergicdiseasesandsensitizationduringthefirstyearoflifeabirthcohortstudy AT chanyokemun maternalvitamindlevelsduringlatepregnancyandriskofallergicdiseasesandsensitizationduringthefirstyearoflifeabirthcohortstudy |