Renal ultrastructural alterations induced by various preparations of mefenamic acid
Mefenamic acid (MFA) treatment is associated with a number of cellular effects that potentiate the incidence of renal toxicity. The aim of this study is to investigate the potential ultrastructural alterations induced by various preparations of MFA (free MFA, MFA-Tween 80 liposomes, and MFA-DDC lipo...
| Principais autores: | , , , , |
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| Formato: | Artigo |
| Publicado em: |
Taylor & Francis
2020
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| _version_ | 1825952246470279168 |
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| author | Jarrar, Qais Bashir Hakim, Muhammad Nazrul Zakaria, Zainul Amiruddin Cheema, Manraj Singh Moshawih, Said |
| author_facet | Jarrar, Qais Bashir Hakim, Muhammad Nazrul Zakaria, Zainul Amiruddin Cheema, Manraj Singh Moshawih, Said |
| author_sort | Jarrar, Qais Bashir |
| collection | UPM |
| description | Mefenamic acid (MFA) treatment is associated with a number of cellular effects that potentiate the incidence of renal toxicity. The aim of this study is to investigate the potential ultrastructural alterations induced by various preparations of MFA (free MFA, MFA-Tween 80 liposomes, and MFA-DDC liposomes) on the renal tissues. Sprague-Dawley rats were subjected to a daily dose of MFA preparations for 28 days. Renal biopsies from all groups of rats under study were processed for transmission electron microscopic examination. The findings revealed that MFA preparations induced various ultrastructural alterations including mitochondrial injury, nuclear and lysosomal alterations, tubular cells steatosis, apoptotic activity, autophagy, and nucleophagy. These alterations were more clear in rats received free MFA, and MFA-Tween 80 liposomes than those received MFA-DDC liposomes. It is concluded that MFA-DDC liposomes are less potential to induce renal damage than free MFA and MFA-Tween 80 liposomes. Thus, MFA-DDC liposomes may offer an advantage of safe drug delivery. |
| first_indexed | 2024-03-06T10:42:03Z |
| format | Article |
| id | upm.eprints-86688 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T10:42:03Z |
| publishDate | 2020 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | upm.eprints-866882023-05-29T06:48:55Z http://psasir.upm.edu.my/id/eprint/86688/ Renal ultrastructural alterations induced by various preparations of mefenamic acid Jarrar, Qais Bashir Hakim, Muhammad Nazrul Zakaria, Zainul Amiruddin Cheema, Manraj Singh Moshawih, Said Mefenamic acid (MFA) treatment is associated with a number of cellular effects that potentiate the incidence of renal toxicity. The aim of this study is to investigate the potential ultrastructural alterations induced by various preparations of MFA (free MFA, MFA-Tween 80 liposomes, and MFA-DDC liposomes) on the renal tissues. Sprague-Dawley rats were subjected to a daily dose of MFA preparations for 28 days. Renal biopsies from all groups of rats under study were processed for transmission electron microscopic examination. The findings revealed that MFA preparations induced various ultrastructural alterations including mitochondrial injury, nuclear and lysosomal alterations, tubular cells steatosis, apoptotic activity, autophagy, and nucleophagy. These alterations were more clear in rats received free MFA, and MFA-Tween 80 liposomes than those received MFA-DDC liposomes. It is concluded that MFA-DDC liposomes are less potential to induce renal damage than free MFA and MFA-Tween 80 liposomes. Thus, MFA-DDC liposomes may offer an advantage of safe drug delivery. Taylor & Francis 2020-01 Article PeerReviewed Jarrar, Qais Bashir and Hakim, Muhammad Nazrul and Zakaria, Zainul Amiruddin and Cheema, Manraj Singh and Moshawih, Said (2020) Renal ultrastructural alterations induced by various preparations of mefenamic acid. Ultrastructural Pathology, 44 (1). pp. 1-11. ISSN 0191-3123; ESSN: 1521-0758 https://www.tandfonline.com/doi/abs/10.1080/01913123.2020.1717705 10.1080/01913123.2020.1717705 |
| spellingShingle | Jarrar, Qais Bashir Hakim, Muhammad Nazrul Zakaria, Zainul Amiruddin Cheema, Manraj Singh Moshawih, Said Renal ultrastructural alterations induced by various preparations of mefenamic acid |
| title | Renal ultrastructural alterations induced by various preparations of mefenamic acid |
| title_full | Renal ultrastructural alterations induced by various preparations of mefenamic acid |
| title_fullStr | Renal ultrastructural alterations induced by various preparations of mefenamic acid |
| title_full_unstemmed | Renal ultrastructural alterations induced by various preparations of mefenamic acid |
| title_short | Renal ultrastructural alterations induced by various preparations of mefenamic acid |
| title_sort | renal ultrastructural alterations induced by various preparations of mefenamic acid |
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