MRI findings of intracranial primary CNS lymphoma in immunocompetent patients: a Malaysian tertiary hospital experience
Introduction: The present study aimed to characterize the MRI features of intracranial primary central nervous system lymphoma (PCNSL) in the Malaysian population, and to compare the findings with other population-based studies. Methods: Twenty-four patients with histologically confirmed PCNSL fro...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/86843/1/2020011611510401_MJMHS_0317.pdf |
| _version_ | 1825952273726963712 |
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| author | Ab Rahman, Siti Soraya Muda, Ahmad Sobri |
| author_facet | Ab Rahman, Siti Soraya Muda, Ahmad Sobri |
| author_sort | Ab Rahman, Siti Soraya |
| collection | UPM |
| description | Introduction: The present study aimed to characterize the MRI features of intracranial primary central nervous system
lymphoma (PCNSL) in the Malaysian population, and to compare the findings with other population-based studies.
Methods: Twenty-four patients with histologically confirmed PCNSL from 2008 to 2014 were identified. Eighteen patients had MRI images at presentation available for review. The images were reviewed by two radiologists, noting the
number, size, location, signal characteristics, perilesional oedema and characteristics of enhancement of the lesions.
Results: Ten patients had solitary lesions, while 8 patients had multiple lesions with a total of 31 lesions. The lesions
were mostly located in the frontal lobe and basal ganglia. Most lesions were hypointense on T1 sequences, hyperintense on T2 sequences, with moderate to marked perilesional oedema. All lesions showed contrast enhancement.
Five lesions demonstrated the ‘notch sign’, 1 lesion showed ‘open-ring’ pattern of enhancement and 1 lesion had
a non-enhancing core. Seventeen lesions demonstrated an uneven enhancement pattern, mainly in lesions that are
abutting the ventricular margins. Conclusion: MRI findings of patients with PCNSL in our population concur with
other population-based studies. Enhancement patterns like the ‘notch sign’, ‘open-ring’, and uneven enhancement
are not uncommon in PCNSL. |
| first_indexed | 2024-03-06T10:42:28Z |
| format | Article |
| id | upm.eprints-86843 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:42:28Z |
| publishDate | 2020 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-868432021-10-11T02:35:05Z http://psasir.upm.edu.my/id/eprint/86843/ MRI findings of intracranial primary CNS lymphoma in immunocompetent patients: a Malaysian tertiary hospital experience Ab Rahman, Siti Soraya Muda, Ahmad Sobri Introduction: The present study aimed to characterize the MRI features of intracranial primary central nervous system lymphoma (PCNSL) in the Malaysian population, and to compare the findings with other population-based studies. Methods: Twenty-four patients with histologically confirmed PCNSL from 2008 to 2014 were identified. Eighteen patients had MRI images at presentation available for review. The images were reviewed by two radiologists, noting the number, size, location, signal characteristics, perilesional oedema and characteristics of enhancement of the lesions. Results: Ten patients had solitary lesions, while 8 patients had multiple lesions with a total of 31 lesions. The lesions were mostly located in the frontal lobe and basal ganglia. Most lesions were hypointense on T1 sequences, hyperintense on T2 sequences, with moderate to marked perilesional oedema. All lesions showed contrast enhancement. Five lesions demonstrated the ‘notch sign’, 1 lesion showed ‘open-ring’ pattern of enhancement and 1 lesion had a non-enhancing core. Seventeen lesions demonstrated an uneven enhancement pattern, mainly in lesions that are abutting the ventricular margins. Conclusion: MRI findings of patients with PCNSL in our population concur with other population-based studies. Enhancement patterns like the ‘notch sign’, ‘open-ring’, and uneven enhancement are not uncommon in PCNSL. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020-01 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86843/1/2020011611510401_MJMHS_0317.pdf Ab Rahman, Siti Soraya and Muda, Ahmad Sobri (2020) MRI findings of intracranial primary CNS lymphoma in immunocompetent patients: a Malaysian tertiary hospital experience. Malaysian Journal of Medicine and Health Sciences, 16 (1). pp. 2-8. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020011611510401_MJMHS_0317.pdf |
| spellingShingle | Ab Rahman, Siti Soraya Muda, Ahmad Sobri MRI findings of intracranial primary CNS lymphoma in immunocompetent patients: a Malaysian tertiary hospital experience |
| title | MRI findings of intracranial primary CNS lymphoma in immunocompetent patients: a Malaysian tertiary hospital experience |
| title_full | MRI findings of intracranial primary CNS lymphoma in immunocompetent patients: a Malaysian tertiary hospital experience |
| title_fullStr | MRI findings of intracranial primary CNS lymphoma in immunocompetent patients: a Malaysian tertiary hospital experience |
| title_full_unstemmed | MRI findings of intracranial primary CNS lymphoma in immunocompetent patients: a Malaysian tertiary hospital experience |
| title_short | MRI findings of intracranial primary CNS lymphoma in immunocompetent patients: a Malaysian tertiary hospital experience |
| title_sort | mri findings of intracranial primary cns lymphoma in immunocompetent patients a malaysian tertiary hospital experience |
| url | http://psasir.upm.edu.my/id/eprint/86843/1/2020011611510401_MJMHS_0317.pdf |
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