Phytochemicals and potential therapeutic targets on toxoplasma gondii parasite
Identification of drug target in protozoan T. gondii is an important step in the development of chemotherapeutic agents. Likewise, exploring phytochemical compounds effective against the parasite can lead to the development of new drug agent that can be useful for prophylaxis and treatment of toxopl...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Bentham Science
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/87192/1/Phytochemicals%20and%20potential%20therapeutic%20targets%20on%20toxoplasma%20gondii%20parasite.pdf |
| _version_ | 1796981815966171136 |
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| author | Abdullahi, Sharif Alhassan Unyah, Ngah Zasmy Nordin, Noshariza Basir, Rusliza Mohammed Nasir, Wana Issa Alapid, Ashraf Ahmad Hassan, Yahaya Mustapha, Tijjani Abd Majid, Roslaini |
| author_facet | Abdullahi, Sharif Alhassan Unyah, Ngah Zasmy Nordin, Noshariza Basir, Rusliza Mohammed Nasir, Wana Issa Alapid, Ashraf Ahmad Hassan, Yahaya Mustapha, Tijjani Abd Majid, Roslaini |
| author_sort | Abdullahi, Sharif Alhassan |
| collection | UPM |
| description | Identification of drug target in protozoan T. gondii is an important step in the development of chemotherapeutic agents. Likewise, exploring phytochemical compounds effective against the parasite can lead to the development of new drug agent that can be useful for prophylaxis and treatment of toxoplasmosis. In this review, we searched for the relevant literature on the herbs that were tested against T. gondii either in vitro or in vivo, as well as different phytochemicals and their potential activities on T. gondii. Potential activities of major phytochemicals, such as alkaloid, flavonoid, terpenoids and tannins on various target sites on T. gondii as well as other related parasites was discussed. It is believed that the phytochemicals from natural sources are potential drug candidates for the treatment of toxoplasmosis with little or no toxicity to humans. |
| first_indexed | 2024-03-06T10:43:10Z |
| format | Article |
| id | upm.eprints-87192 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:43:10Z |
| publishDate | 2020 |
| publisher | Bentham Science |
| record_format | dspace |
| spelling | upm.eprints-871922022-01-13T07:39:36Z http://psasir.upm.edu.my/id/eprint/87192/ Phytochemicals and potential therapeutic targets on toxoplasma gondii parasite Abdullahi, Sharif Alhassan Unyah, Ngah Zasmy Nordin, Noshariza Basir, Rusliza Mohammed Nasir, Wana Issa Alapid, Ashraf Ahmad Hassan, Yahaya Mustapha, Tijjani Abd Majid, Roslaini Identification of drug target in protozoan T. gondii is an important step in the development of chemotherapeutic agents. Likewise, exploring phytochemical compounds effective against the parasite can lead to the development of new drug agent that can be useful for prophylaxis and treatment of toxoplasmosis. In this review, we searched for the relevant literature on the herbs that were tested against T. gondii either in vitro or in vivo, as well as different phytochemicals and their potential activities on T. gondii. Potential activities of major phytochemicals, such as alkaloid, flavonoid, terpenoids and tannins on various target sites on T. gondii as well as other related parasites was discussed. It is believed that the phytochemicals from natural sources are potential drug candidates for the treatment of toxoplasmosis with little or no toxicity to humans. Bentham Science 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/87192/1/Phytochemicals%20and%20potential%20therapeutic%20targets%20on%20toxoplasma%20gondii%20parasite.pdf Abdullahi, Sharif Alhassan and Unyah, Ngah Zasmy and Nordin, Noshariza and Basir, Rusliza and Mohammed Nasir, Wana and Issa Alapid, Ashraf Ahmad and Hassan, Yahaya and Mustapha, Tijjani and Abd Majid, Roslaini (2020) Phytochemicals and potential therapeutic targets on toxoplasma gondii parasite. Mini-Reviews in Medicinal Chemistry, 20 (9). 739 - 753. ISSN 1389-5575; ESSN:1875-5607 https://www.eurekaselect.com/176265/article 10.2174/1389557519666191029105736 |
| spellingShingle | Abdullahi, Sharif Alhassan Unyah, Ngah Zasmy Nordin, Noshariza Basir, Rusliza Mohammed Nasir, Wana Issa Alapid, Ashraf Ahmad Hassan, Yahaya Mustapha, Tijjani Abd Majid, Roslaini Phytochemicals and potential therapeutic targets on toxoplasma gondii parasite |
| title | Phytochemicals and potential therapeutic targets on toxoplasma gondii parasite |
| title_full | Phytochemicals and potential therapeutic targets on toxoplasma gondii parasite |
| title_fullStr | Phytochemicals and potential therapeutic targets on toxoplasma gondii parasite |
| title_full_unstemmed | Phytochemicals and potential therapeutic targets on toxoplasma gondii parasite |
| title_short | Phytochemicals and potential therapeutic targets on toxoplasma gondii parasite |
| title_sort | phytochemicals and potential therapeutic targets on toxoplasma gondii parasite |
| url | http://psasir.upm.edu.my/id/eprint/87192/1/Phytochemicals%20and%20potential%20therapeutic%20targets%20on%20toxoplasma%20gondii%20parasite.pdf |
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