Pilus islets and the clonal spread of piliated Streptococcus pneumoniae: a review
Pneumococci are a common cause of severe infections, such as otitis media, pneumonia, meningitis and bacteremia. Pili are detected in a small proportion of pneumococcal population, but these structures have recently been associated with bacterial virulence in humans. Therefore, the epidemiological r...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/87196/1/Pilus%20islets%20and%20the%20clonal%20spread%20of%20piliated.pdf |
| _version_ | 1825952332640157696 |
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| author | Dzaraly, Nurul Diana Muthana, Abdulrahman Mohd Desa, Mohd Nasir Mohd Taib, Niazlin Masri, Siti Norbaya A. Rahman, Nor Izaida Suhaili, Zarizal Tuan Soh, Tuan Suhaila Abdullah, Fatimah Haslina |
| author_facet | Dzaraly, Nurul Diana Muthana, Abdulrahman Mohd Desa, Mohd Nasir Mohd Taib, Niazlin Masri, Siti Norbaya A. Rahman, Nor Izaida Suhaili, Zarizal Tuan Soh, Tuan Suhaila Abdullah, Fatimah Haslina |
| author_sort | Dzaraly, Nurul Diana |
| collection | UPM |
| description | Pneumococci are a common cause of severe infections, such as otitis media, pneumonia, meningitis and bacteremia. Pili are detected in a small proportion of pneumococcal population, but these structures have recently been associated with bacterial virulence in humans. Therefore, the epidemiological relationships between pneumococcal pili, serotype and antimicrobial resistance are of interest. This study aims to discuss the virulence contribution of the Streptococcus pneumoniae pili and the epidemiological relationships among the pilus genes, antimicrobial resistance trends, regional serotypes and genotypic variations. Previous reports have characterized the pneumococcal pilus islet as a clonal feature in the pneumococcal serotypes that are covered by the pneumococcal conjugate vaccine (PCV), including serotypes 19A, 19F, 23F and 7F. Many of the pneumococcal molecular epidemiology network (PMEN) clones are piliated isolates that are also strongly associated with a high frequency of multidrug resistance. Most of these piliated pneumococcal isolates belong to a few clonal complexes (CC), such as CC320, CC199, CC271, CC191 and CC156. Additional molecular epidemiology and genomic studies, particularly whole genome sequence analysis (WGS), are needed to develop an in-depth understanding of the piliated pneumococcal isolates. |
| first_indexed | 2024-03-06T10:43:11Z |
| format | Article |
| id | upm.eprints-87196 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:43:11Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-871962022-01-13T08:20:09Z http://psasir.upm.edu.my/id/eprint/87196/ Pilus islets and the clonal spread of piliated Streptococcus pneumoniae: a review Dzaraly, Nurul Diana Muthana, Abdulrahman Mohd Desa, Mohd Nasir Mohd Taib, Niazlin Masri, Siti Norbaya A. Rahman, Nor Izaida Suhaili, Zarizal Tuan Soh, Tuan Suhaila Abdullah, Fatimah Haslina Pneumococci are a common cause of severe infections, such as otitis media, pneumonia, meningitis and bacteremia. Pili are detected in a small proportion of pneumococcal population, but these structures have recently been associated with bacterial virulence in humans. Therefore, the epidemiological relationships between pneumococcal pili, serotype and antimicrobial resistance are of interest. This study aims to discuss the virulence contribution of the Streptococcus pneumoniae pili and the epidemiological relationships among the pilus genes, antimicrobial resistance trends, regional serotypes and genotypic variations. Previous reports have characterized the pneumococcal pilus islet as a clonal feature in the pneumococcal serotypes that are covered by the pneumococcal conjugate vaccine (PCV), including serotypes 19A, 19F, 23F and 7F. Many of the pneumococcal molecular epidemiology network (PMEN) clones are piliated isolates that are also strongly associated with a high frequency of multidrug resistance. Most of these piliated pneumococcal isolates belong to a few clonal complexes (CC), such as CC320, CC199, CC271, CC191 and CC156. Additional molecular epidemiology and genomic studies, particularly whole genome sequence analysis (WGS), are needed to develop an in-depth understanding of the piliated pneumococcal isolates. Elsevier 2020-08-27 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/87196/1/Pilus%20islets%20and%20the%20clonal%20spread%20of%20piliated.pdf Dzaraly, Nurul Diana and Muthana, Abdulrahman and Mohd Desa, Mohd Nasir and Mohd Taib, Niazlin and Masri, Siti Norbaya and A. Rahman, Nor Izaida and Suhaili, Zarizal and Tuan Soh, Tuan Suhaila and Abdullah, Fatimah Haslina (2020) Pilus islets and the clonal spread of piliated Streptococcus pneumoniae: a review. International Journal of Medical Microbiology, 310 (7). art. no. 151449. pp. 1-7. ISSN 1438-4221 https://www.sciencedirect.com/science/article/pii/S143842212030059X?dgcid=rss_sd_all 10.1016/j.ijmm.2020.151449 |
| spellingShingle | Dzaraly, Nurul Diana Muthana, Abdulrahman Mohd Desa, Mohd Nasir Mohd Taib, Niazlin Masri, Siti Norbaya A. Rahman, Nor Izaida Suhaili, Zarizal Tuan Soh, Tuan Suhaila Abdullah, Fatimah Haslina Pilus islets and the clonal spread of piliated Streptococcus pneumoniae: a review |
| title | Pilus islets and the clonal spread of piliated Streptococcus pneumoniae: a review |
| title_full | Pilus islets and the clonal spread of piliated Streptococcus pneumoniae: a review |
| title_fullStr | Pilus islets and the clonal spread of piliated Streptococcus pneumoniae: a review |
| title_full_unstemmed | Pilus islets and the clonal spread of piliated Streptococcus pneumoniae: a review |
| title_short | Pilus islets and the clonal spread of piliated Streptococcus pneumoniae: a review |
| title_sort | pilus islets and the clonal spread of piliated streptococcus pneumoniae a review |
| url | http://psasir.upm.edu.my/id/eprint/87196/1/Pilus%20islets%20and%20the%20clonal%20spread%20of%20piliated.pdf |
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