Potential miRNAs for miRNA-based therapeutics in breast cancer
MicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate the genes involved in critical cellular processes. The aberrant expressions of oncogenic or tumor suppressor miRNAs have been associated with cancer progression and malignancies. This resulted in the dysregulation...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Multidisciplinary Digital Publishing Institute
2020
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/87221/1/Potential%20miRNAs%20for%20miRNA.pdf |
| _version_ | 1796981820943761408 |
|---|---|
| author | Wong, Jun Sheng Cheah, Yoke Kqueen |
| author_facet | Wong, Jun Sheng Cheah, Yoke Kqueen |
| author_sort | Wong, Jun Sheng |
| collection | UPM |
| description | MicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate the genes involved in critical cellular processes. The aberrant expressions of oncogenic or tumor suppressor miRNAs have been associated with cancer progression and malignancies. This resulted in the dysregulation of signaling pathways involved in cell proliferation, apoptosis and survival, metastasis, cancer recurrence and chemoresistance. In this review, we will first (i) provide an overview of the miRNA biogenesis pathways, and in vitro and in vivo models for research, (ii) summarize the most recent findings on the roles of microRNAs (miRNAs) that could potentially be used for miRNA-based therapy in the treatment of breast cancer and (iii) discuss the various therapeutic applications. |
| first_indexed | 2024-03-06T10:43:15Z |
| format | Article |
| id | upm.eprints-87221 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:43:15Z |
| publishDate | 2020 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-872212022-01-20T02:41:11Z http://psasir.upm.edu.my/id/eprint/87221/ Potential miRNAs for miRNA-based therapeutics in breast cancer Wong, Jun Sheng Cheah, Yoke Kqueen MicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate the genes involved in critical cellular processes. The aberrant expressions of oncogenic or tumor suppressor miRNAs have been associated with cancer progression and malignancies. This resulted in the dysregulation of signaling pathways involved in cell proliferation, apoptosis and survival, metastasis, cancer recurrence and chemoresistance. In this review, we will first (i) provide an overview of the miRNA biogenesis pathways, and in vitro and in vivo models for research, (ii) summarize the most recent findings on the roles of microRNAs (miRNAs) that could potentially be used for miRNA-based therapy in the treatment of breast cancer and (iii) discuss the various therapeutic applications. Multidisciplinary Digital Publishing Institute 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/87221/1/Potential%20miRNAs%20for%20miRNA.pdf Wong, Jun Sheng and Cheah, Yoke Kqueen (2020) Potential miRNAs for miRNA-based therapeutics in breast cancer. Non-coding RNA, 6 (3). art. no. 29. pp. 1-39. ISSN 2311-553X https://www.mdpi.com/2311-553X/6/3/29 10.3390/ncrna6030029 |
| spellingShingle | Wong, Jun Sheng Cheah, Yoke Kqueen Potential miRNAs for miRNA-based therapeutics in breast cancer |
| title | Potential miRNAs for miRNA-based therapeutics in breast cancer |
| title_full | Potential miRNAs for miRNA-based therapeutics in breast cancer |
| title_fullStr | Potential miRNAs for miRNA-based therapeutics in breast cancer |
| title_full_unstemmed | Potential miRNAs for miRNA-based therapeutics in breast cancer |
| title_short | Potential miRNAs for miRNA-based therapeutics in breast cancer |
| title_sort | potential mirnas for mirna based therapeutics in breast cancer |
| url | http://psasir.upm.edu.my/id/eprint/87221/1/Potential%20miRNAs%20for%20miRNA.pdf |
| work_keys_str_mv | AT wongjunsheng potentialmirnasformirnabasedtherapeuticsinbreastcancer AT cheahyokekqueen potentialmirnasformirnabasedtherapeuticsinbreastcancer |