Safety and efficacy of dabigatran versus warfarin in Asian patients with atrial fibrillation
Introduction: Nonvalvular atrial fibrillation is a common cause of cardioembolic stroke which accounts around 50% of all cardioembolic emboli. Oral anticoagulants remain the main choice of stroke prevention in patients with atrial fibrillation. Our study is aimed to determine the safety (absence o...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine and Health Science, Universiti Putra Malaysia
2020
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/87519/1/2020120208341112_MJMHS_0712.pdf |
| _version_ | 1825952377425887232 |
|---|---|
| author | Inche Mat, Liyana Najwa Ooi, Qi Wen Johari, Nurul Natasha Ashikin Subramaniam, Rooban Raao Wan Sulaiman, Wan Aliaa Hoo, Fan Kee Chia, Peck Kee Basri, Hamidon |
| author_facet | Inche Mat, Liyana Najwa Ooi, Qi Wen Johari, Nurul Natasha Ashikin Subramaniam, Rooban Raao Wan Sulaiman, Wan Aliaa Hoo, Fan Kee Chia, Peck Kee Basri, Hamidon |
| author_sort | Inche Mat, Liyana Najwa |
| collection | UPM |
| description | Introduction: Nonvalvular atrial fibrillation is a common cause of cardioembolic stroke which accounts around
50% of all cardioembolic emboli. Oral anticoagulants remain the main choice of stroke prevention in patients with
atrial fibrillation. Our study is aimed to determine the safety (absence or presence of bleeding events) and efficacy
(absence or presence of ischemic stroke occurrence) of dabigatran versus warfarin for stroke prevention in patients
with nonvalvular atrial fibrillation. Methods: A retrospective audit study was conducted based on past data obtained
from Electronic Hospital Information System (EHIS) records in Serdang Hospital. Our sample was 150 patients with
nonvalvular atrial fibrillation who were at risk of getting stroke and being prescribed with oral anticoagulants either
warfarin or dabigatran from the year 2013 until 2019. Results: Our study showed that there was lesser occurrence
of ischemic stroke in patients from dabigatran group (1.3%) as compared to those in warfarin group (2.7%). There
were also almost 2 times lesser bleeding events in dabigatran group (6.7%) as compared to those in warfarin group
(14.7%). The median of CHA2DS2-VASc Score in warfarin sampled patients (median=3+/-1) was lower than dabigatran sampled patients (median=4+/-1). Conclusion: Both warfarin and dabigatran are effective in preventing stroke
for patients with nonvalvular atrial fibrillation. However, dabigatran is associated with lesser bleeding events with
lower incidence of major bleeds compared to warfarin. |
| first_indexed | 2024-03-06T10:43:43Z |
| format | Article |
| id | upm.eprints-87519 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:43:43Z |
| publishDate | 2020 |
| publisher | Faculty of Medicine and Health Science, Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-875192023-05-17T02:37:49Z http://psasir.upm.edu.my/id/eprint/87519/ Safety and efficacy of dabigatran versus warfarin in Asian patients with atrial fibrillation Inche Mat, Liyana Najwa Ooi, Qi Wen Johari, Nurul Natasha Ashikin Subramaniam, Rooban Raao Wan Sulaiman, Wan Aliaa Hoo, Fan Kee Chia, Peck Kee Basri, Hamidon Introduction: Nonvalvular atrial fibrillation is a common cause of cardioembolic stroke which accounts around 50% of all cardioembolic emboli. Oral anticoagulants remain the main choice of stroke prevention in patients with atrial fibrillation. Our study is aimed to determine the safety (absence or presence of bleeding events) and efficacy (absence or presence of ischemic stroke occurrence) of dabigatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. Methods: A retrospective audit study was conducted based on past data obtained from Electronic Hospital Information System (EHIS) records in Serdang Hospital. Our sample was 150 patients with nonvalvular atrial fibrillation who were at risk of getting stroke and being prescribed with oral anticoagulants either warfarin or dabigatran from the year 2013 until 2019. Results: Our study showed that there was lesser occurrence of ischemic stroke in patients from dabigatran group (1.3%) as compared to those in warfarin group (2.7%). There were also almost 2 times lesser bleeding events in dabigatran group (6.7%) as compared to those in warfarin group (14.7%). The median of CHA2DS2-VASc Score in warfarin sampled patients (median=3+/-1) was lower than dabigatran sampled patients (median=4+/-1). Conclusion: Both warfarin and dabigatran are effective in preventing stroke for patients with nonvalvular atrial fibrillation. However, dabigatran is associated with lesser bleeding events with lower incidence of major bleeds compared to warfarin. Faculty of Medicine and Health Science, Universiti Putra Malaysia 2020-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/87519/1/2020120208341112_MJMHS_0712.pdf Inche Mat, Liyana Najwa and Ooi, Qi Wen and Johari, Nurul Natasha Ashikin and Subramaniam, Rooban Raao and Wan Sulaiman, Wan Aliaa and Hoo, Fan Kee and Chia, Peck Kee and Basri, Hamidon (2020) Safety and efficacy of dabigatran versus warfarin in Asian patients with atrial fibrillation. Malaysian Journal of Medicine and Health Sciences, 16 (4). 89 - 95. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020120208341112_MJMHS_0712.pdf |
| spellingShingle | Inche Mat, Liyana Najwa Ooi, Qi Wen Johari, Nurul Natasha Ashikin Subramaniam, Rooban Raao Wan Sulaiman, Wan Aliaa Hoo, Fan Kee Chia, Peck Kee Basri, Hamidon Safety and efficacy of dabigatran versus warfarin in Asian patients with atrial fibrillation |
| title | Safety and efficacy of dabigatran versus warfarin in Asian patients with atrial fibrillation |
| title_full | Safety and efficacy of dabigatran versus warfarin in Asian patients with atrial fibrillation |
| title_fullStr | Safety and efficacy of dabigatran versus warfarin in Asian patients with atrial fibrillation |
| title_full_unstemmed | Safety and efficacy of dabigatran versus warfarin in Asian patients with atrial fibrillation |
| title_short | Safety and efficacy of dabigatran versus warfarin in Asian patients with atrial fibrillation |
| title_sort | safety and efficacy of dabigatran versus warfarin in asian patients with atrial fibrillation |
| url | http://psasir.upm.edu.my/id/eprint/87519/1/2020120208341112_MJMHS_0712.pdf |
| work_keys_str_mv | AT inchematliyananajwa safetyandefficacyofdabigatranversuswarfarininasianpatientswithatrialfibrillation AT ooiqiwen safetyandefficacyofdabigatranversuswarfarininasianpatientswithatrialfibrillation AT joharinurulnatashaashikin safetyandefficacyofdabigatranversuswarfarininasianpatientswithatrialfibrillation AT subramaniamroobanraao safetyandefficacyofdabigatranversuswarfarininasianpatientswithatrialfibrillation AT wansulaimanwanaliaa safetyandefficacyofdabigatranversuswarfarininasianpatientswithatrialfibrillation AT hoofankee safetyandefficacyofdabigatranversuswarfarininasianpatientswithatrialfibrillation AT chiapeckkee safetyandefficacyofdabigatranversuswarfarininasianpatientswithatrialfibrillation AT basrihamidon safetyandefficacyofdabigatranversuswarfarininasianpatientswithatrialfibrillation |