An overview of in vitro, in vivo, and computational techniques for cancer-associated angiogenesis studies
Angiogenesis is a crucial area in scientific research because it involves many important physiological and pathological processes. Indeed, angiogenesis is critical for normal physiological processes, including wound healing and embryonic development, as well as being a component of many disorders, s...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/87845/1/ABSTRACT.pdf |
| _version_ | 1825952419690840064 |
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| author | Rahman, Heshu Sulaiman Tan, Bee Ling Othman, Hemn Hassan Chartrand, Max Stanley Pathak, Yashwant Mohan, Syam Abdullah, Rasedee Alitheen, Noorjahan Banu |
| author_facet | Rahman, Heshu Sulaiman Tan, Bee Ling Othman, Hemn Hassan Chartrand, Max Stanley Pathak, Yashwant Mohan, Syam Abdullah, Rasedee Alitheen, Noorjahan Banu |
| author_sort | Rahman, Heshu Sulaiman |
| collection | UPM |
| description | Angiogenesis is a crucial area in scientific research because it involves many important physiological and pathological processes. Indeed, angiogenesis is critical for normal physiological processes, including wound healing and embryonic development, as well as being a component of many disorders, such as rheumatoid arthritis, obesity, and diabetic retinopathies. Investigations of angiogenic mechanisms require assays that can activate the critical steps of angiogenesis as well as provide a tool for assessing the efficacy of therapeutic agents. Thus, angiogenesis assays are key tools for studying the mechanisms of angiogenesis and identifying the potential therapeutic strategies to modulate neovascularization. However, the regulation of angiogenesis is highly complex and not fully understood. Difficulties in assessing the regulators of angiogenic response have necessitated the development of an alternative approach. In this paper, we review the standard models for the study of tumor angiogenesis on the macroscopic scale that include in vitro, in vivo, and computational models. We also highlight the differences in several modeling approaches and describe key advances in understanding the computational models that contributed to the knowledge base of the field. |
| first_indexed | 2024-03-06T10:44:21Z |
| format | Article |
| id | upm.eprints-87845 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:44:21Z |
| publishDate | 2020 |
| publisher | Hindawi Publishing |
| record_format | dspace |
| spelling | upm.eprints-878452022-06-14T08:33:17Z http://psasir.upm.edu.my/id/eprint/87845/ An overview of in vitro, in vivo, and computational techniques for cancer-associated angiogenesis studies Rahman, Heshu Sulaiman Tan, Bee Ling Othman, Hemn Hassan Chartrand, Max Stanley Pathak, Yashwant Mohan, Syam Abdullah, Rasedee Alitheen, Noorjahan Banu Angiogenesis is a crucial area in scientific research because it involves many important physiological and pathological processes. Indeed, angiogenesis is critical for normal physiological processes, including wound healing and embryonic development, as well as being a component of many disorders, such as rheumatoid arthritis, obesity, and diabetic retinopathies. Investigations of angiogenic mechanisms require assays that can activate the critical steps of angiogenesis as well as provide a tool for assessing the efficacy of therapeutic agents. Thus, angiogenesis assays are key tools for studying the mechanisms of angiogenesis and identifying the potential therapeutic strategies to modulate neovascularization. However, the regulation of angiogenesis is highly complex and not fully understood. Difficulties in assessing the regulators of angiogenic response have necessitated the development of an alternative approach. In this paper, we review the standard models for the study of tumor angiogenesis on the macroscopic scale that include in vitro, in vivo, and computational models. We also highlight the differences in several modeling approaches and describe key advances in understanding the computational models that contributed to the knowledge base of the field. Hindawi Publishing 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/87845/1/ABSTRACT.pdf Rahman, Heshu Sulaiman and Tan, Bee Ling and Othman, Hemn Hassan and Chartrand, Max Stanley and Pathak, Yashwant and Mohan, Syam and Abdullah, Rasedee and Alitheen, Noorjahan Banu (2020) An overview of in vitro, in vivo, and computational techniques for cancer-associated angiogenesis studies. Biomed Research International, 2020. pp. 1-14. ISSN 2314-6133; ESSN: 2314-6141 https://www.hindawi.com/journals/bmri/2020/8857428/ 10.1155/2020/8857428 |
| spellingShingle | Rahman, Heshu Sulaiman Tan, Bee Ling Othman, Hemn Hassan Chartrand, Max Stanley Pathak, Yashwant Mohan, Syam Abdullah, Rasedee Alitheen, Noorjahan Banu An overview of in vitro, in vivo, and computational techniques for cancer-associated angiogenesis studies |
| title | An overview of in vitro, in vivo, and computational techniques for cancer-associated angiogenesis studies |
| title_full | An overview of in vitro, in vivo, and computational techniques for cancer-associated angiogenesis studies |
| title_fullStr | An overview of in vitro, in vivo, and computational techniques for cancer-associated angiogenesis studies |
| title_full_unstemmed | An overview of in vitro, in vivo, and computational techniques for cancer-associated angiogenesis studies |
| title_short | An overview of in vitro, in vivo, and computational techniques for cancer-associated angiogenesis studies |
| title_sort | overview of in vitro in vivo and computational techniques for cancer associated angiogenesis studies |
| url | http://psasir.upm.edu.my/id/eprint/87845/1/ABSTRACT.pdf |
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