Effect of addition of PVA/PG to oil-in-water nanoemulsion Kojic monooleate formulation on droplet size: three-factors response surface optimization and characterization
An oil in water (O/W) nanoemulsion formulation containing kojic monooleate (KMO) in thin film system was developed. Response surface methodology (RSM) was used to optimize and analyzed the effect of three variables, namely concentration of polyvinyl alcohol (PVA) (20–30% w/w), concentration of propy...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Multidisciplinary Digital Publishing Institute
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/88564/1/ABSTRACT.pdf |
| _version_ | 1796981991963361280 |
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| author | Mohd Jaslina, Nur Farzana Izzati Faujan, Nur Hana Mohamad, Rosfarizan Ashari, Siti Efliza |
| author_facet | Mohd Jaslina, Nur Farzana Izzati Faujan, Nur Hana Mohamad, Rosfarizan Ashari, Siti Efliza |
| author_sort | Mohd Jaslina, Nur Farzana Izzati |
| collection | UPM |
| description | An oil in water (O/W) nanoemulsion formulation containing kojic monooleate (KMO) in thin film system was developed. Response surface methodology (RSM) was used to optimize and analyzed the effect of three variables, namely concentration of polyvinyl alcohol (PVA) (20–30% w/w), concentration of propylene glycol (PG) (1–10% w/w), and shear rate of high shear homogenizer (3000–9000 rpm) on droplet size as a response, while other compositions remained constant such as KMO (10.0% w/w), Tween 80 (3.19% w/w), castor oil (3.74% w/w), xanthan gum (0.70% w/w), and germall plus (0.7% w/w, PG (and) diazolidinyl urea (and) iodopropynyl butylcarbamate). The optimized KMO nanoemulsion formulation with desirable criteria was PVA (27.61% w/w) and PG (1.05% w/w), and shear rate (8656.17 rpm) with a predicted droplet size (110.21 nm) and actual droplet size (105.93 nm) with a residual standard error (RSE) of less than 2.0% was obtained. Analysis of variance (ANOVA) showed that the fitness of the quadratic polynomial fit the experimental data with a F-value of 65.30, p–value of p < 0.0001, and a non-significant lack-of-fit. The optimized KMO formulation shows the desired criteria of the thin film system and the physicochemical properties (Zeta potential −37.37 mV, PDI 0.13, pH 4.74) and stability at four different conditions indicate its suitability for cosmeceutical applications. |
| first_indexed | 2024-03-06T10:45:47Z |
| format | Article |
| id | upm.eprints-88564 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:45:47Z |
| publishDate | 2020 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-885642021-12-21T08:06:45Z http://psasir.upm.edu.my/id/eprint/88564/ Effect of addition of PVA/PG to oil-in-water nanoemulsion Kojic monooleate formulation on droplet size: three-factors response surface optimization and characterization Mohd Jaslina, Nur Farzana Izzati Faujan, Nur Hana Mohamad, Rosfarizan Ashari, Siti Efliza An oil in water (O/W) nanoemulsion formulation containing kojic monooleate (KMO) in thin film system was developed. Response surface methodology (RSM) was used to optimize and analyzed the effect of three variables, namely concentration of polyvinyl alcohol (PVA) (20–30% w/w), concentration of propylene glycol (PG) (1–10% w/w), and shear rate of high shear homogenizer (3000–9000 rpm) on droplet size as a response, while other compositions remained constant such as KMO (10.0% w/w), Tween 80 (3.19% w/w), castor oil (3.74% w/w), xanthan gum (0.70% w/w), and germall plus (0.7% w/w, PG (and) diazolidinyl urea (and) iodopropynyl butylcarbamate). The optimized KMO nanoemulsion formulation with desirable criteria was PVA (27.61% w/w) and PG (1.05% w/w), and shear rate (8656.17 rpm) with a predicted droplet size (110.21 nm) and actual droplet size (105.93 nm) with a residual standard error (RSE) of less than 2.0% was obtained. Analysis of variance (ANOVA) showed that the fitness of the quadratic polynomial fit the experimental data with a F-value of 65.30, p–value of p < 0.0001, and a non-significant lack-of-fit. The optimized KMO formulation shows the desired criteria of the thin film system and the physicochemical properties (Zeta potential −37.37 mV, PDI 0.13, pH 4.74) and stability at four different conditions indicate its suitability for cosmeceutical applications. Multidisciplinary Digital Publishing Institute 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88564/1/ABSTRACT.pdf Mohd Jaslina, Nur Farzana Izzati and Faujan, Nur Hana and Mohamad, Rosfarizan and Ashari, Siti Efliza (2020) Effect of addition of PVA/PG to oil-in-water nanoemulsion Kojic monooleate formulation on droplet size: three-factors response surface optimization and characterization. Cosmetics, 7 (4). art. no. 73. pp. 1-14. ISSN 2079-9284 https://www.mdpi.com/2079-9284/7/4/73 10.3390/cosmetics7040073 |
| spellingShingle | Mohd Jaslina, Nur Farzana Izzati Faujan, Nur Hana Mohamad, Rosfarizan Ashari, Siti Efliza Effect of addition of PVA/PG to oil-in-water nanoemulsion Kojic monooleate formulation on droplet size: three-factors response surface optimization and characterization |
| title | Effect of addition of PVA/PG to oil-in-water nanoemulsion Kojic monooleate formulation on droplet size: three-factors response surface optimization and characterization |
| title_full | Effect of addition of PVA/PG to oil-in-water nanoemulsion Kojic monooleate formulation on droplet size: three-factors response surface optimization and characterization |
| title_fullStr | Effect of addition of PVA/PG to oil-in-water nanoemulsion Kojic monooleate formulation on droplet size: three-factors response surface optimization and characterization |
| title_full_unstemmed | Effect of addition of PVA/PG to oil-in-water nanoemulsion Kojic monooleate formulation on droplet size: three-factors response surface optimization and characterization |
| title_short | Effect of addition of PVA/PG to oil-in-water nanoemulsion Kojic monooleate formulation on droplet size: three-factors response surface optimization and characterization |
| title_sort | effect of addition of pva pg to oil in water nanoemulsion kojic monooleate formulation on droplet size three factors response surface optimization and characterization |
| url | http://psasir.upm.edu.my/id/eprint/88564/1/ABSTRACT.pdf |
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