Elacteriospermum tapos ameliorates maternal obesity effect on serum leptin changes in male offspring
The purpose of this study is to investigate the effect of Elateriospermum tapos aqueous extract supplementation on serum leptin of male offspring at weaning. A total of 30 female Sprague Dawley rats were assigned to two groups, where the control group (CG) consisted of six rats and the remaining rat...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Multidisciplinary Digital Publishing Institute
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/88762/1/LEPTIN.pdf |
| _version_ | 1825936567431069696 |
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| author | Balan, Santhra Segaran Zainal Abidin, Azrina Perumal, Kokila Vani Shafie, Nurul Husna Abdullah, Maizaton Atmadini Jasni, Azmiza Syawani Abdul Kadir, Khairul Kamilah Bahari, Hasnah |
| author_facet | Balan, Santhra Segaran Zainal Abidin, Azrina Perumal, Kokila Vani Shafie, Nurul Husna Abdullah, Maizaton Atmadini Jasni, Azmiza Syawani Abdul Kadir, Khairul Kamilah Bahari, Hasnah |
| author_sort | Balan, Santhra Segaran |
| collection | UPM |
| description | The purpose of this study is to investigate the effect of Elateriospermum tapos aqueous extract supplementation on serum leptin of male offspring at weaning. A total of 30 female Sprague Dawley rats were assigned to two groups, where the control group (CG) consisted of six rats and the remaining rats had obesity-induced over five weeks with a high-fat diet pellet and cafeteria food. After five weeks, the obese group was further divided into four groups, a negative control group (NG), positive control group (PG) (orlistat 200 mg/kg), treatment 1 (TX1) (200 mg/kg BW of E. tapos seed) and treatment 2 (TX2) (200 mg/kg BW of E. tapos shell) for 6 weeks. After six weeks, all rats were mated and continued with their respective diet till weaning. One male pup from each dam culled at weaning (postnatal day 21 (PND21)). The results show that body weight in male offspring (M) from negative group dams (NG) was significantly heavier as compared to other pup groups. Total adipose tissue weight in MTX1 and MTX2 of the male offspring was also significantly lower compared to MNG. In mums, serum leptin of NG was significantly higher as compared to the CG group, whereas both treatment groups showed a significant reduction in serum leptin compared to the NG group. In pups, the MTX2 group showed a more substantial reduction in body weight and serum leptin compared to other pups from other mother’s groups. In conclusion, E. tapos aqueous extract supplementation has a greater effect on ameliorating maternal obesity effects on male offspring by lowering body weight, inhibit fat deposition, and reducing serum leptin. |
| first_indexed | 2024-03-06T10:46:15Z |
| format | Article |
| id | upm.eprints-88762 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:46:15Z |
| publishDate | 2020 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-887622021-10-06T08:50:16Z http://psasir.upm.edu.my/id/eprint/88762/ Elacteriospermum tapos ameliorates maternal obesity effect on serum leptin changes in male offspring Balan, Santhra Segaran Zainal Abidin, Azrina Perumal, Kokila Vani Shafie, Nurul Husna Abdullah, Maizaton Atmadini Jasni, Azmiza Syawani Abdul Kadir, Khairul Kamilah Bahari, Hasnah The purpose of this study is to investigate the effect of Elateriospermum tapos aqueous extract supplementation on serum leptin of male offspring at weaning. A total of 30 female Sprague Dawley rats were assigned to two groups, where the control group (CG) consisted of six rats and the remaining rats had obesity-induced over five weeks with a high-fat diet pellet and cafeteria food. After five weeks, the obese group was further divided into four groups, a negative control group (NG), positive control group (PG) (orlistat 200 mg/kg), treatment 1 (TX1) (200 mg/kg BW of E. tapos seed) and treatment 2 (TX2) (200 mg/kg BW of E. tapos shell) for 6 weeks. After six weeks, all rats were mated and continued with their respective diet till weaning. One male pup from each dam culled at weaning (postnatal day 21 (PND21)). The results show that body weight in male offspring (M) from negative group dams (NG) was significantly heavier as compared to other pup groups. Total adipose tissue weight in MTX1 and MTX2 of the male offspring was also significantly lower compared to MNG. In mums, serum leptin of NG was significantly higher as compared to the CG group, whereas both treatment groups showed a significant reduction in serum leptin compared to the NG group. In pups, the MTX2 group showed a more substantial reduction in body weight and serum leptin compared to other pups from other mother’s groups. In conclusion, E. tapos aqueous extract supplementation has a greater effect on ameliorating maternal obesity effects on male offspring by lowering body weight, inhibit fat deposition, and reducing serum leptin. Multidisciplinary Digital Publishing Institute 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88762/1/LEPTIN.pdf Balan, Santhra Segaran and Zainal Abidin, Azrina and Perumal, Kokila Vani and Shafie, Nurul Husna and Abdullah, Maizaton Atmadini and Jasni, Azmiza Syawani and Abdul Kadir, Khairul Kamilah and Bahari, Hasnah (2020) Elacteriospermum tapos ameliorates maternal obesity effect on serum leptin changes in male offspring. Proceedings, 61 (1). pp. 1-6. ISSN 2504-3900 https://www.mdpi.com/2504-3900/61/1/3 10.3390/IECN2020-07007 |
| spellingShingle | Balan, Santhra Segaran Zainal Abidin, Azrina Perumal, Kokila Vani Shafie, Nurul Husna Abdullah, Maizaton Atmadini Jasni, Azmiza Syawani Abdul Kadir, Khairul Kamilah Bahari, Hasnah Elacteriospermum tapos ameliorates maternal obesity effect on serum leptin changes in male offspring |
| title | Elacteriospermum tapos ameliorates maternal obesity effect on serum leptin changes in male offspring |
| title_full | Elacteriospermum tapos ameliorates maternal obesity effect on serum leptin changes in male offspring |
| title_fullStr | Elacteriospermum tapos ameliorates maternal obesity effect on serum leptin changes in male offspring |
| title_full_unstemmed | Elacteriospermum tapos ameliorates maternal obesity effect on serum leptin changes in male offspring |
| title_short | Elacteriospermum tapos ameliorates maternal obesity effect on serum leptin changes in male offspring |
| title_sort | elacteriospermum tapos ameliorates maternal obesity effect on serum leptin changes in male offspring |
| url | http://psasir.upm.edu.my/id/eprint/88762/1/LEPTIN.pdf |
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