Human mesenchymal stem cells inhibit the differentiation and effector functions of monocytes
Although monocytes represent an essential part of the host defence system, their accumulation and prolonged stimulation could be detrimental and may aggravate chronic inflammatory diseases. The present study has explored the less-understood immunomodulatory effects of mesenchymal stem cells on monoc...
| Hoofdauteurs: | , , , , , , |
|---|---|
| Formaat: | Artikel |
| Taal: | English |
| Gepubliceerd in: |
SAGE Publications
2020
|
| Online toegang: | http://psasir.upm.edu.my/id/eprint/89220/1/STEM.pdf |
| _version_ | 1825936642862481408 |
|---|---|
| author | Maqbool, Maryam Algraittee, Satar Jabbar Rahi Borojerdi, Mohadese Hashem Sarmadi, Vahid Hosseinpour John, Cini Mathew Vidyadaran, Sharmili Ramasamy, Rajesh |
| author_facet | Maqbool, Maryam Algraittee, Satar Jabbar Rahi Borojerdi, Mohadese Hashem Sarmadi, Vahid Hosseinpour John, Cini Mathew Vidyadaran, Sharmili Ramasamy, Rajesh |
| author_sort | Maqbool, Maryam |
| collection | UPM |
| description | Although monocytes represent an essential part of the host defence system, their accumulation and prolonged stimulation could be detrimental and may aggravate chronic inflammatory diseases. The present study has explored the less-understood immunomodulatory effects of mesenchymal stem cells on monocyte functions. Isolated purified human monocytes were co-cultured with human umbilical cord-derived mesenchymal stem cells under appropriate culture conditions to assess monocytes’ vital functions. Based on the surface marker analysis, mesenchymal stem cells halted monocyte differentiation into dendritic cells and macrophages and reduced their phagocytosis functions, which rendered an inability to stimulate T-cell proliferation. The present study confers that mesenchymal stem cells exerted potent immunosuppressive activity on monocyte functions such as differentiation, phagocytosis and Ag presentation; hence, they promise a potential therapeutic role in down-regulating the unwanted monocyte-mediated immune responses in the context of chronic inflammatory diseases. |
| first_indexed | 2024-03-06T10:47:24Z |
| format | Article |
| id | upm.eprints-89220 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:47:24Z |
| publishDate | 2020 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | upm.eprints-892202021-09-03T21:05:09Z http://psasir.upm.edu.my/id/eprint/89220/ Human mesenchymal stem cells inhibit the differentiation and effector functions of monocytes Maqbool, Maryam Algraittee, Satar Jabbar Rahi Borojerdi, Mohadese Hashem Sarmadi, Vahid Hosseinpour John, Cini Mathew Vidyadaran, Sharmili Ramasamy, Rajesh Although monocytes represent an essential part of the host defence system, their accumulation and prolonged stimulation could be detrimental and may aggravate chronic inflammatory diseases. The present study has explored the less-understood immunomodulatory effects of mesenchymal stem cells on monocyte functions. Isolated purified human monocytes were co-cultured with human umbilical cord-derived mesenchymal stem cells under appropriate culture conditions to assess monocytes’ vital functions. Based on the surface marker analysis, mesenchymal stem cells halted monocyte differentiation into dendritic cells and macrophages and reduced their phagocytosis functions, which rendered an inability to stimulate T-cell proliferation. The present study confers that mesenchymal stem cells exerted potent immunosuppressive activity on monocyte functions such as differentiation, phagocytosis and Ag presentation; hence, they promise a potential therapeutic role in down-regulating the unwanted monocyte-mediated immune responses in the context of chronic inflammatory diseases. SAGE Publications 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/89220/1/STEM.pdf Maqbool, Maryam and Algraittee, Satar Jabbar Rahi and Borojerdi, Mohadese Hashem and Sarmadi, Vahid Hosseinpour and John, Cini Mathew and Vidyadaran, Sharmili and Ramasamy, Rajesh (2020) Human mesenchymal stem cells inhibit the differentiation and effector functions of monocytes. Innate Immunity, 26 (5). 424 - 434. ISSN 1753-4259; ESSN: 1753-4267 https://journals.sagepub.com/doi/10.1177/1753425919899132?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 10.1177/1753425919899132 |
| spellingShingle | Maqbool, Maryam Algraittee, Satar Jabbar Rahi Borojerdi, Mohadese Hashem Sarmadi, Vahid Hosseinpour John, Cini Mathew Vidyadaran, Sharmili Ramasamy, Rajesh Human mesenchymal stem cells inhibit the differentiation and effector functions of monocytes |
| title | Human mesenchymal stem cells inhibit the differentiation and effector functions of monocytes |
| title_full | Human mesenchymal stem cells inhibit the differentiation and effector functions of monocytes |
| title_fullStr | Human mesenchymal stem cells inhibit the differentiation and effector functions of monocytes |
| title_full_unstemmed | Human mesenchymal stem cells inhibit the differentiation and effector functions of monocytes |
| title_short | Human mesenchymal stem cells inhibit the differentiation and effector functions of monocytes |
| title_sort | human mesenchymal stem cells inhibit the differentiation and effector functions of monocytes |
| url | http://psasir.upm.edu.my/id/eprint/89220/1/STEM.pdf |
| work_keys_str_mv | AT maqboolmaryam humanmesenchymalstemcellsinhibitthedifferentiationandeffectorfunctionsofmonocytes AT algraitteesatarjabbarrahi humanmesenchymalstemcellsinhibitthedifferentiationandeffectorfunctionsofmonocytes AT borojerdimohadesehashem humanmesenchymalstemcellsinhibitthedifferentiationandeffectorfunctionsofmonocytes AT sarmadivahidhosseinpour humanmesenchymalstemcellsinhibitthedifferentiationandeffectorfunctionsofmonocytes AT johncinimathew humanmesenchymalstemcellsinhibitthedifferentiationandeffectorfunctionsofmonocytes AT vidyadaransharmili humanmesenchymalstemcellsinhibitthedifferentiationandeffectorfunctionsofmonocytes AT ramasamyrajesh humanmesenchymalstemcellsinhibitthedifferentiationandeffectorfunctionsofmonocytes |