Induced pluripotent stem cells: reprogramming platforms and applications in cell replacement therapy
The generation of induced pluripotent stem cells (iPSCs) from differentiated mature cells is one of the most promising technologies in the field of regenerative medicine. The ability to generate patient-specific iPSCs offers an invaluable reservoir of pluripotent cells, which could be genetically en...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/89345/1/STEM.pdf |
| _version_ | 1796982124049334272 |
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| author | Al Abbar, Akram Ngai, Siew Ching Nograles, Nadine Alhaji, Suleiman Yusuf Abdullah, Syahril |
| author_facet | Al Abbar, Akram Ngai, Siew Ching Nograles, Nadine Alhaji, Suleiman Yusuf Abdullah, Syahril |
| author_sort | Al Abbar, Akram |
| collection | UPM |
| description | The generation of induced pluripotent stem cells (iPSCs) from differentiated mature cells is one of the most promising technologies in the field of regenerative medicine. The ability to generate patient-specific iPSCs offers an invaluable reservoir of pluripotent cells, which could be genetically engineered and differentiated into target cells to treat various genetic and degenerative diseases once transplanted, hence counteracting the risk of graft versus host disease. In this context, we review the scientific research streams that lead to the emergence of iPSCs,
the roles of reprogramming factors in reprogramming to pluripotency, and the reprogramming strategies. As iPSCs serve tremendous correction potentials for various diseases, we highlight the successes and challenges of iPSCs in cell replacement therapy and the synergy of iPSCs and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing tools in therapeutics research. |
| first_indexed | 2024-03-06T10:47:44Z |
| format | Article |
| id | upm.eprints-89345 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:47:44Z |
| publishDate | 2020 |
| publisher | Mary Ann Liebert |
| record_format | dspace |
| spelling | upm.eprints-893452021-09-03T04:21:47Z http://psasir.upm.edu.my/id/eprint/89345/ Induced pluripotent stem cells: reprogramming platforms and applications in cell replacement therapy Al Abbar, Akram Ngai, Siew Ching Nograles, Nadine Alhaji, Suleiman Yusuf Abdullah, Syahril The generation of induced pluripotent stem cells (iPSCs) from differentiated mature cells is one of the most promising technologies in the field of regenerative medicine. The ability to generate patient-specific iPSCs offers an invaluable reservoir of pluripotent cells, which could be genetically engineered and differentiated into target cells to treat various genetic and degenerative diseases once transplanted, hence counteracting the risk of graft versus host disease. In this context, we review the scientific research streams that lead to the emergence of iPSCs, the roles of reprogramming factors in reprogramming to pluripotency, and the reprogramming strategies. As iPSCs serve tremendous correction potentials for various diseases, we highlight the successes and challenges of iPSCs in cell replacement therapy and the synergy of iPSCs and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing tools in therapeutics research. Mary Ann Liebert 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/89345/1/STEM.pdf Al Abbar, Akram and Ngai, Siew Ching and Nograles, Nadine and Alhaji, Suleiman Yusuf and Abdullah, Syahril (2020) Induced pluripotent stem cells: reprogramming platforms and applications in cell replacement therapy. BioResearch Open Access, 9 (spec.1). 121 - 136. ISSN 2164-7860 https://www.liebertpub.com/doi/10.1089/biores.2019.0046?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed 10.1089/biores.2019.0046 |
| spellingShingle | Al Abbar, Akram Ngai, Siew Ching Nograles, Nadine Alhaji, Suleiman Yusuf Abdullah, Syahril Induced pluripotent stem cells: reprogramming platforms and applications in cell replacement therapy |
| title | Induced pluripotent stem cells: reprogramming platforms and applications in cell replacement therapy |
| title_full | Induced pluripotent stem cells: reprogramming platforms and applications in cell replacement therapy |
| title_fullStr | Induced pluripotent stem cells: reprogramming platforms and applications in cell replacement therapy |
| title_full_unstemmed | Induced pluripotent stem cells: reprogramming platforms and applications in cell replacement therapy |
| title_short | Induced pluripotent stem cells: reprogramming platforms and applications in cell replacement therapy |
| title_sort | induced pluripotent stem cells reprogramming platforms and applications in cell replacement therapy |
| url | http://psasir.upm.edu.my/id/eprint/89345/1/STEM.pdf |
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